{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:35:02Z","timestamp":1789792502813,"version":"4.0.1"},"reference-count":61,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Central Denmark Region Health Survey"},{"name":"The Health Research Foundation of Central Denmark Region","award":["R86-A4212"],"award-info":[{"award-number":["R86-A4212"]}]},{"name":"Institute of Public Health, Aarhus University"},{"name":"The Central Denmark Region Fund for Strengthening of Health Science"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Multimorbidity and Comorbidity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify population groups with distinct multimorbidity patterns and to examine their associations with high treatment burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Latent class analysis was conducted using cross-sectional, self-reported data on 16 long-term conditions from Danish adults aged 25 years and older in treatment (N = 14,344), drawn from the Danish National Health Survey. Treatment burden was assessed using the Multimorbidity Treatment Burden Questionnaire, and associations between identified multimorbidity patterns and high treatment burden (score \u226522) were examined using a bias-adjusted three-step approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight latent classes were identified: 1\n                      <jats:italic toggle=\"yes\">Hypertension<\/jats:italic>\n                      (31% of the study population); 2\n                      <jats:italic toggle=\"yes\">Mental health disorders<\/jats:italic>\n                      (21%); 3\n                      <jats:italic toggle=\"yes\">Musculoskeletal disorders<\/jats:italic>\n                      (17%); 4\n                      <jats:italic toggle=\"yes\">Complex<\/jats:italic>\n                      <jats:italic toggle=\"yes\">cardiometabolic-<\/jats:italic>\n                      <jats:italic toggle=\"yes\">musculoskeletal<\/jats:italic>\n                      <jats:italic toggle=\"yes\">disorders<\/jats:italic>\n                      (10%); 5\n                      <jats:italic toggle=\"yes\">Complex<\/jats:italic>\n                      <jats:italic toggle=\"yes\">headache-mental-back-disorders<\/jats:italic>\n                      (7%); 6\n                      <jats:italic toggle=\"yes\">Asthma-<\/jats:italic>\n                      <jats:italic toggle=\"yes\">allergy<\/jats:italic>\n                      (6%); 7\n                      <jats:italic toggle=\"yes\">Cataract-<\/jats:italic>\n                      <jats:italic toggle=\"yes\">respiratory<\/jats:italic>\n                      <jats:italic toggle=\"yes\">disorders<\/jats:italic>\n                      (5%); and 8\n                      <jats:italic toggle=\"yes\">Complex<\/jats:italic>\n                      <jats:italic toggle=\"yes\">respiratory-<\/jats:italic>\n                      <jats:italic toggle=\"yes\">musculoskeletal<\/jats:italic>\n                      <jats:italic toggle=\"yes\">disorders<\/jats:italic>\n                      (3%). Overall, 13% experienced a high treatment burden. This proportion varied from 0.5% in Class 3 to 48% in Class 5, with the highest proportions associated with Classes 4 (27%), 5 (48%), and 8 (26%). The three complex multimorbidity groups averaged more than four conditions per individual and, compared to Class 1, were associated with a non-Danish background, being temporarily or permanently out of work, low social support, and difficulties engaging with healthcare providers. The prevalence of high treatment burden and the strength of its association with disease patterns decreased with age, while no substantial differences were observed across sexes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Specific multimorbidity patterns were strongly associated with high treatment burden. These findings may inform healthcare planning, resource allocation, and tailored interventions to reduce treatment burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/26335565261417433","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:55:38Z","timestamp":1773226538000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Multimorbidity patterns and their associations with patient-perceived treatment burden: A latent class analysis of 14,344 Danish adults"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8472-0555","authenticated-orcid":false,"given":"Marie Hauge","family":"Pedersen","sequence":"first","affiliation":[{"name":"DEFACTUM \u2013 Public Health Research"},{"name":"Aarhus University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5808-8883","authenticated-orcid":false,"given":"Mathias","family":"Lasgaard","sequence":"additional","affiliation":[{"name":"DEFACTUM \u2013 Public Health Research"},{"name":"University of Southern Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9199-3463","authenticated-orcid":false,"given":"Camilla Palmh\u00f8j","family":"Nielsen","sequence":"additional","affiliation":[{"name":"DEFACTUM \u2013 Public Health Research"},{"name":"Aarhus University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4053-3701","authenticated-orcid":false,"given":"Anders","family":"Prior","sequence":"additional","affiliation":[{"name":"Aarhus University"},{"name":"Research Unit for General Practice"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polly","family":"Duncan","sequence":"additional","affiliation":[{"name":"University of Bristol"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8039-8095","authenticated-orcid":false,"given":"Stine","family":"Schramm","sequence":"additional","affiliation":[{"name":"University of Southern Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6848-123X","authenticated-orcid":false,"given":"Finn Breinholt","family":"Larsen","sequence":"additional","affiliation":[{"name":"DEFACTUM \u2013 Public Health Research"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp11X548929"},{"key":"e_1_3_9_3_2","volume-title":"Danskernes sundhed \u2013 Den nationale sundhedsprofil 2021 [The health of the Danes \u2013 The national health profile 2021]","author":"Jensen HAR","year":"2022","unstructured":"Jensen HAR, Davidsen M, M\u00f8ller SR, et al. Danskernes sundhed \u2013 Den nationale sundhedsprofil 2021 [The health of the Danes \u2013 The national health profile 2021]. K\u00f8benhavn: Sundhedsstyrelsen; 2022."},{"key":"e_1_3_9_4_2","volume-title":"Danskernes sundhed \u2013 Den nationale sundhedsprofil 2017 [The health of the Danes \u2013 The national health profile 2017]","author":"Jensen HAR","year":"2018","unstructured":"Jensen HAR, Davidsen M, Ekholm O, et al. Danskernes sundhed \u2013 Den nationale sundhedsprofil 2017 [The health of the Danes \u2013 The national health profile 2017]. K\u00f8benhavn: Sundhedsstyrelsen; 2018."},{"key":"e_1_3_9_5_2","volume-title":"Hvidbog om multisygdom. Dokumentation af multisygdom i det danske samfund - fra silot\u00e6nkning til sammenh\u00e6ng [White Paper on Multimorbidity: Documentation of Multimorbidity in Danish Society \u2013 From Silo Thinking to Integration]","author":"Fr\u00f8lich A","year":"2017","unstructured":"Fr\u00f8lich A, Olesen F, Kristensen I. Hvidbog om multisygdom. Dokumentation af multisygdom i det danske samfund - fra silot\u00e6nkning til sammenh\u00e6ng [White Paper on Multimorbidity: Documentation of Multimorbidity in Danish Society \u2013 From Silo Thinking to Integration]. 1st ed.. Denmark: Fjerritslev, 2017.","edition":"1"},{"key":"e_1_3_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60240-2"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2017.05.003"},{"key":"e_1_3_9_8_2","doi-asserted-by":"publisher","DOI":"10.2147\/clep.S129415"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39201.463819.2C"},{"key":"e_1_3_9_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169426"},{"key":"e_1_3_9_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/mlr.0000000000000632"},{"key":"e_1_3_9_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.20.2269"},{"key":"e_1_3_9_13_2","volume-title":"Multisygdom i den danske befolkning \u2013 forekomsten af multisygdomsm\u00f8nstre og sammenh\u00e6ngen med sociodemografiske faktorer og helbredsrelateret livskvalitet [Multimorbidity in the Danish population \u2013 the prevalence of multimorbidity patterns and the association with socio-demographic factors and health-related quality of life]","author":"Pedersen MH","year":"2022","unstructured":"Pedersen MH, Larsen FB. Multisygdom i den danske befolkning \u2013 forekomsten af multisygdomsm\u00f8nstre og sammenh\u00e6ngen med sociodemografiske faktorer og helbredsrelateret livskvalitet [Multimorbidity in the Danish population \u2013 the prevalence of multimorbidity patterns and the association with socio-demographic factors and health-related quality of life]. Aarhus: DEFACTUM, Region Midtjylland, 2022."},{"key":"e_1_3_9_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-14-281"},{"key":"e_1_3_9_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-007-0322-1"},{"key":"e_1_3_9_16_2","doi-asserted-by":"publisher","DOI":"10.1370\/afm.4"},{"key":"e_1_3_9_17_2","doi-asserted-by":"publisher","DOI":"10.15256\/joc.2016.6.81"},{"key":"e_1_3_9_18_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.121349"},{"key":"e_1_3_9_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1742395317731607"},{"key":"e_1_3_9_20_2","doi-asserted-by":"publisher","DOI":"10.2147\/PROM.S34681"},{"key":"e_1_3_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.05.005"},{"key":"e_1_3_9_22_2","doi-asserted-by":"publisher","DOI":"10.1370\/afm.2178"},{"key":"e_1_3_9_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4843"},{"key":"e_1_3_9_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-12-109"},{"key":"e_1_3_9_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-055276"},{"key":"e_1_3_9_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40271-016-0175-y"},{"key":"e_1_3_9_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081852"},{"key":"e_1_3_9_28_2","doi-asserted-by":"publisher","unstructured":"Duncan P Murphy M Man MS et al. Development and validation of the Multimorbidity Treatment Burden Questionnaire (MTBQ). BMJ Open 2018; 8: e019413-012017-019413. DOI: 10.1136\/bmjopen-2017-019413.","DOI":"10.1136\/bmjopen-2017-019413"},{"key":"e_1_3_9_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e3182a977da"},{"key":"e_1_3_9_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2019.05.013"},{"key":"e_1_3_9_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/nhs.12320"},{"key":"e_1_3_9_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-015-3512-2"},{"key":"e_1_3_9_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-004694"},{"key":"e_1_3_9_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2023.11.004"},{"key":"e_1_3_9_35_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1081518"},{"key":"e_1_3_9_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2022.10.011"},{"key":"e_1_3_9_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/0095798420930932"},{"key":"e_1_3_9_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494820966534"},{"key":"e_1_3_9_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_3_9_40_2","unstructured":"Statistics Denmark. FOLK1A: Befolkningen den 1. i kvartalet efter omr\u00e5de k\u00f8n alder og civilstand [FOLK1A: Population on the 1st of the quarter by area sex age and marital status]. Available: https:\/\/www.statistikbanken.dk\/FOLK1A [Accessed 10 February 2025]."},{"key":"e_1_3_9_41_2","volume-title":"Hvordan har du det? 2021 \u2013 Sundhedsprofil for region og kommuner [How are you? 2021 \u2013 Health profile for region and municipalities]","author":"Friis K","year":"2022","unstructured":"Friis K, Jensen MM, Pedersen MH, et al. Hvordan har du det? 2021 \u2013 Sundhedsprofil for region og kommuner [How are you? 2021 \u2013 Health profile for region and municipalities]. Aarhus: DEFACTUM, Region Midtjylland, 2022, Volume 1."},{"key":"e_1_3_9_42_2","first-page":"21","volume-title":"EUROHIS: Developing common instruments for health surveys","author":"Buratta V","year":"2003","unstructured":"Buratta V, Frova L, Gargiulo L, et al. Development of a common instrument for chronic physical conditions. In: Nosikov A, Gudex C (eds) EUROHIS: Developing common instruments for health surveys. IOS Press, 2003, pp.21-34."},{"key":"e_1_3_9_43_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-080096"},{"key":"e_1_3_9_44_2","unstructured":"OECD Eurostat and UNESCO Institute for Statistics. ISCED 2011 operational manual: Guidelines for classifying national education programmes and related qualifications. Paris: OECD Publishing 2015."},{"key":"e_1_3_9_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(91)90150-b"},{"key":"e_1_3_9_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2887-9"},{"key":"e_1_3_9_47_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-658"},{"key":"e_1_3_9_48_2","doi-asserted-by":"crossref","unstructured":"S\u00e4rndal C-E Lundstr\u00f6m S. Estimation in surveys with nonresponse. West Sussex England: Wiley 2005.","DOI":"10.1002\/0470011351"},{"key":"e_1_3_9_49_2","doi-asserted-by":"publisher","DOI":"10.1080\/10705511.2019.1590146"},{"key":"e_1_3_9_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/bmsp.12227"},{"key":"e_1_3_9_51_2","doi-asserted-by":"publisher","DOI":"10.1080\/10705510701575396"},{"key":"e_1_3_9_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordhb\/9780199934898.013.0025"},{"key":"e_1_3_9_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/pan\/mpq025"},{"key":"e_1_3_9_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/pan\/mph001"},{"key":"e_1_3_9_55_2","doi-asserted-by":"publisher","DOI":"10.1177\/0081175012470644"},{"key":"e_1_3_9_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/pan\/mpu003"},{"key":"e_1_3_9_57_2","unstructured":"Vermunt JK Magidson J. Technical Guide for Latent GOLD 5.1: Basic Advanced and Syntax. Belmont MA: Statistical Innovations Inc; 2016."},{"key":"e_1_3_9_58_2","unstructured":"Larsen FB Pedersen MH Lasgaard M et al. Hvordan har du det? 2017 \u2013 Sundhedsprofil for region og kommuner [How are you? 2017 \u2013 Health profile for region and municipalities] (Volume 1). Aarhus: DEFACTUM Region Midtjylland; 2018."},{"key":"e_1_3_9_59_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-053274"},{"key":"e_1_3_9_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s41669-019-0167-7"},{"key":"e_1_3_9_61_2","doi-asserted-by":"publisher","DOI":"10.23889\/ijpds.v7i4.1759"},{"key":"e_1_3_9_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckac032"}],"container-title":["Journal of Multimorbidity and Comorbidity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/26335565261417433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/26335565261417433","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/26335565261417433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:16:12Z","timestamp":1779185772000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/26335565261417433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":61,"alternative-id":["10.1177\/26335565261417433"],"URL":"https:\/\/doi.org\/10.1177\/26335565261417433","relation":{},"ISSN":["2633-5565","2633-5565"],"issn-type":[{"value":"2633-5565","type":"print"},{"value":"2633-5565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"article-number":"26335565261417433"}}