{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:38:36Z","timestamp":1781285916113,"version":"3.54.1"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"NIHR Health and Social Care Delivery Research (HSDR) programme","award":["ref. 16\/118\/14"],"award-info":[{"award-number":["ref. 16\/118\/14"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Multimorbidity and Comorbidity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Understanding relationships between polypharmacy, treatment burden and other factors (e.g. age, knowledge of medicines), could inform interventions to reduce treatment burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To explore sociodemographic, clinical and medication factors associated with high treatment burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and setting<\/jats:title>\n                    <jats:p>Secondary analysis of multi-centre UK primary care baseline clinical trial data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were \u226518 years, prescribed \u22655 repeat medicines with \u22651 indicator of potentially inappropriate prescribing (PIP). Survey data captured treatment burden (13-item Multimorbidity Treatment Burden Questionnaire; dichotomised with high burden \u226522), sociodemographic characteristics, quality of life, self-reported knowledge of medicines, and medication adherence. Electronic health records provided data on age, gender, long-term conditions, PIP, medicines use (last 3 months), and consultations (last 12 months). Associations between treatment burden and other factors were modelled using multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>1711 adults from 37 general practices were included (mean age 72 years, 51% male). 381 (23%) reported high treatment burden. Multivariable analysis found high treatment burden was associated with younger age, being unemployed or in paid work, university or high education, multimorbidity, anxiety\/depression, polypharmacy (\u22658 medicines), lower medication adherence, knowledge of medicines, and quality of life. There was strong evidence (p&lt;0.005) that the association between high treatment burden and polypharmacy was greater in people aged &lt;60 years, those with poor knowledge of medicines, more multimorbidity, and those with low\/moderate medication adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High treatment burden was more common in adults with polypharmacy who were younger, had multimorbidity, poor medication knowledge, or low adherence. This should inform design of interventions addressing treatment burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/26335565261420367","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T10:29:36Z","timestamp":1773224976000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations between treatment burden, socio-demographics, clinical factors and use of medicines in adults with polypharmacy: A cross-sectional study"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2244-3254","authenticated-orcid":false,"given":"Polly","family":"Duncan","sequence":"first","affiliation":[{"name":"University of Bristol"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5555-1469","authenticated-orcid":false,"given":"Chloe","family":"Gamlin","sequence":"additional","affiliation":[{"name":"University of Bristol"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2768-293X","authenticated-orcid":false,"given":"Deborah","family":"McCahon","sequence":"additional","affiliation":[{"name":"University of Bristol"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1253-307X","authenticated-orcid":false,"given":"Daisy","family":"Gaunt","sequence":"additional","affiliation":[{"name":"University of Bristol"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1166-6374","authenticated-orcid":false,"given":"Beenish","family":"Ashfaq","sequence":"additional","affiliation":[{"name":"University of Bristol"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5842-4645","authenticated-orcid":false,"given":"Rupert A.","family":"Payne","sequence":"additional","affiliation":[{"name":"University of Exeter"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.2147\/prom.s34681"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-14-281"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60240-2"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp11X548929"},{"key":"e_1_3_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101860"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019413"},{"key":"e_1_3_9_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-055276"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp.2020.0883"},{"key":"e_1_3_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.05.005"},{"key":"e_1_3_9_11_2","doi-asserted-by":"publisher","DOI":"10.1370\/afm.1249"},{"key":"e_1_3_9_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-013-1639-9"},{"key":"e_1_3_9_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0322-7"},{"key":"e_1_3_9_14_2","unstructured":"Duerden M Avery T Payne R. 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