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The incidence varies from 0.2 to 2.5:100\u2009000 people per year, with a prevalence of 38 to 57 cases per 100\u2009000 people. The main characteristics of ET are the marked thrombocytosis and the high frequency of thrombosis. The spectrum of symptoms is quite wide, but fatigue results to be the most frequent. Thrombosis is frequently observed, often occurring before or at the time of diagnosis. The classification of thrombotic risk has undergone several revisions. Recently, the revised-IPSET-t has distinguished 4 risk classes, from very low risk to high risk. Driver mutations seem to influence thrombotic risk and prognosis, while the role of sub-driver mutations still remains uncertain. Antiplatelet therapy is recommended in all patients aged \u2a7e 60\u2009years and in those with a positive history of thrombosis or with cardiovascular risk factors, while cytoreductive therapy with hydroxyurea or interferon is reserved for high-risk patients.<\/jats:p>","DOI":"10.1177\/2634853520978210","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T06:03:54Z","timestamp":1609135434000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":38,"title":["The Essential Thrombocythemia in 2020: What We Know and Where We Still Have to Dig Deep"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0161-0957","authenticated-orcid":false,"given":"Vincenzo","family":"Accurso","sequence":"first","affiliation":[{"name":"Hematology Division University Hospital Policlinico \u201cPaolo Giaccone\u201d, Palermo, 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