{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:38:04Z","timestamp":1780364284991,"version":"3.54.1"},"reference-count":8,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Video Journal of Sports Medicine"],"published-print":{"date-parts":[[2025,5]]},"abstract":"\n Background:<\/jats:title>\n Damage to the joint surface, which affects articular cartilage and the underlying subchondral bone, is a common cause for significant knee pain and disfunction. The use of CartiHeal Agili-C, a cell-free aragonite-based implant, is an emerging option for patients who may otherwise be a poor candidate for allograft transplantation or within geographic areas where there is a limited availability of donor tissue.<\/jats:p>\n <\/jats:sec>\n \n Indications:<\/jats:title>\n \n The CartiHeal Agili-C implant is indicated for patients with an International Cartilage Repair Society grade III or IV lesion with a total treatable area of 1 to 7 cm\n 2<\/jats:sup>\n and without severe osteoarthritis.\n <\/jats:p>\n <\/jats:sec>\n \n Technique Description:<\/jats:title>\n Standard parapatellar arthrotomy is performed to reveal an osteochondral defect of the femoral condyle. The cell-free aragonite-based scaffold is then transplanted in 7 steps according to numbered instrumentation in the Agili-C toolset. Surgical pearls of placement include proper alignment of the perpendicular aligner tool with circumferential viewing, assistant confirmation, and arthroscopic verification; avoiding wobbling during the shaping phase of the procedure as this may cause an oblong socket with inadequate fixation; and handling the implant with care and only using a thumb or index finger to insert with light tapping.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n A multicenter randomized control trial followed 251 patients and found 88.5% of the implant group had at least 75% lesion fill as seen on postoperative magnetic resonance imaging at a 2-year follow-up. Additionally, patient-reported outcome measures were statistically superior when compared to controls at 24 months.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Transplantation of a cell-free aragonite-based scaffold (Aglili-C; CartiHeal Ltd), augmented with bone marrow aspirate concentrate, provides an efficient, reproducible surgical strategy in the management of osteochondral defects of the femoral condyles.<\/jats:p>\n <\/jats:sec>\n \n Patient Consent Disclosure Statement:<\/jats:title>\n The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/26350254241303767","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T06:00:28Z","timestamp":1750917628000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Cell-Free Aragonite-Based Scaffold With Bone Marrow Aspirate Concentrate Augmentation for Osteochondral Defects of the Knee"],"prefix":"10.1177","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9283-1439","authenticated-orcid":false,"given":"Ron","family":"Gilat","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C.","family":"Weissman","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-7346","authenticated-orcid":false,"given":"Allen A.","family":"Yazdi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0819-5981","authenticated-orcid":false,"given":"Sarah A.","family":"Muth","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-2113","authenticated-orcid":false,"given":"Brian J.","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465231151252"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546503259345"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546512472044"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520980087"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/2325967118801931"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520981750"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200300002-00007"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947603520988164"}],"container-title":["Video Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/26350254241303767","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/26350254241303767","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/26350254241303767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:21:27Z","timestamp":1777598487000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/26350254241303767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1177\/26350254241303767"],"URL":"https:\/\/doi.org\/10.1177\/26350254241303767","relation":{},"ISSN":["2635-0254","2635-0254"],"issn-type":[{"value":"2635-0254","type":"print"},{"value":"2635-0254","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"article-number":"26350254241303767"}}