{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:19:02Z","timestamp":1788322742018,"version":"build-2803163510"},"reference-count":48,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Cinfa Salud de la Mujer"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Women's Health Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Endometriosis is a chronic, estrogen-dependent inflammatory condition affecting approximately 10% of women of reproductive age and manifesting with pelvic pain, dysmenorrhea, dyspareunia, fatigue, and infertility. First-line treatment in most patients is hormonal therapy, and among the available options, contraceptives are frequently used. Short-acting contraceptives (SACs) have been employed off-label to manage endometriosis-related symptoms, yet comparative evidence regarding optimal formulations and regimens remains limited. This narrative review, part of the Agnodice Project, aims to synthesize recent evidence on the SAC formulation-specific effectiveness for endometriosis management, and to provide evidence-based practical considerations for endometriosis management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A literature search of systematic reviews and\/or meta-analyses providing data on non-contraceptive clinical benefits of SAC versus other SAC or SAC vs placebo or no treatment, including the period from 2014 to 2024, was conducted. Information was extracted as individual items related to endometriosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 86 studies included in the Agnodice Project, 10 systematic reviews and meta-analyses specifically addressed endometriosis, yielding 21 comparative items with significant differences. SACs effectively reduced dysmenorrhea, chronic pelvic pain, and post-operative endometrioma recurrence, among others. Continuous regimens consistently outperformed cyclic schedules for pain control and quality of life. Among formulations, desogestrel monotherapy was superior across multiple outcomes in women with endometriosis. Furthermore, we present practical, expert considerations based on the synthesized evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>SACs represent valuable first-line therapeutic options for endometriosis symptom management, with continuous regimens providing optimal symptom control and recurrence prevention. Formulation selection should be individualized based on symptom profile, safety profile, comorbidities, estrogen tolerance, and patient preference.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/26884844261476400","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:29:56Z","timestamp":1788150596000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring Short-Acting Hormonal Contraceptives in Endometriosis Care\u2014A Narrative Review and Evidence-Based Practical Considerations"],"prefix":"10.1177","volume":"7","author":[{"given":"M. \u00c1ngeles","family":"Mart\u00ednez-Zamora","sequence":"first","affiliation":[{"name":"Gynecology Department, Cl\u00ednic Institute of Gyneacology, Obstetrics and Neonatology (ICGON), Hospital Clinic of Barcelona, Universitat de Barcelona, Barcelona, Spain."},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS), Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Perell\u00f3-Cap\u00f3","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Obstetrics and Gynecology, Preventive Medicine and Public Health, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain."},{"name":"Department of Obstetrics and Gynecology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquim","family":"Calaf-Alsina","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Obstetrics and Gynecology, Preventive Medicine and Public Health, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain."},{"name":"Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 C.","family":"Qu\u00edlez-Conde","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hospital Universitario de Basurto, Bilbao, Spain."},{"name":"Centro Ginecol\u00f3gico y Medicina Fetal (CEGyMF), Bilbao, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,30]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1000274"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804690"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082815"},{"key":"e_1_3_3_5_1","unstructured":"4.Institute for Health Metrics and Evaluation. Endometriosis\u2014Level 4 cause n.d. 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Endometriosis: Diagnosis and management\u2014NICE guideline NG73 2017. Available from: https:\/\/www.nice.org.uk\/guidance\/ng73 [Last accessed: April29 2026]."},{"key":"e_1_3_3_18_1","unstructured":"17.Ministerio de Sanidad Servicios Sociales e Igualdad. Gu\u00eda de atenci\u00f3n a las mujeres con endometriosis en el Sistema Nacional de Salud n.d. 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