{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:20:21Z","timestamp":1777882821627,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Palliative Medicine Reports"],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Treatment with antihypertensives in patients with advanced cancer is often continued until very late in the disease trajectory, despite a considerable risk of hypotension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the time of deprescribing of antihypertensive agents in patients with cancer receiving palliative care during their last year of life. The monitoring of blood pressure (BP) during treatment was also studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting\/Subjects:<\/jats:title>\n                    <jats:p>Medical records of all patients admitted during a three-year period to a home care unit in Stockholm, Sweden, and now deceased were screened for antihypertensive agents. To create a homogenous cohort, only agents of the renin-angiotensin system (ATC-code C09) were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements:<\/jats:title>\n                    <jats:p>Data for time of deprescribing and monitoring of BP were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 1501 deceased patients, 353 had been treated with agents of the renin-angiotensin system for hypertension and had a primary diagnosis of cancer. BP was measured before deprescribing in 169 patients (47.9%). In 102 patients (28.9%), antihypertensive treatment continued up to the last seven days of life. For 27 patients (7.6%), the treatment had not been deprescribed. In 184 patients (52, 1%), BP was not followed up despite continued antihypertensive treatment. All 27 patients whose treatment was never deprescribed were in this group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This study shows that antihypertensive treatment is often deprescribed late or not at all in patients with advanced cancer. Monitoring BP in patients treated with antihypertensives in palliative care may facilitate making the decision to deprescribe them in time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/26892820251372015","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:25:17Z","timestamp":1759944317000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Late Deprescribing of Angiotensin-Converting-Enzyme\u00a0Inhibitors and Renin-Angiotensin Blockers in Patients with Advanced Cancer Receiving Palliative Care"],"prefix":"10.1177","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3505-9283","authenticated-orcid":false,"given":"Linda","family":"Bj\u00f6rkhem-Bergman","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden."},{"name":"Department\/Palliative Care, Stockholms Sjukhems R&amp;D, Stockholm, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christel","family":"Hedman","sequence":"additional","affiliation":[{"name":"Department\/Palliative Care, Stockholms Sjukhems R&amp;D, Stockholm, Sweden."},{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden."},{"name":"Department of Clinical Sciences Lund, Lund University, Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1t\u00e9","family":"Szilcz","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, C8 Medicinsk epidemiologi och biostatistik, MEB Jonell, Karolinska Institutet, Stockholm, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3817-0577","authenticated-orcid":false,"given":"Gabriella","family":"Frisk","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society (NVS), Karolinska Institutet, Huddinge, Sweden."},{"name":"ASIH Stockholm S\u00f6dra, Advanced home care and Specialized palliative ward, Nacka, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2322-0"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.19-4-311"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-016-0327-0"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/15360288.2016.1204411"},{"issue":"5","key":"e_1_3_4_6_2","first-page":"613","article-title":"Deprescribing in Palliative Cancer Care","volume":"12","author":"Hedman C","year":"2022","unstructured":"Hedman C, , Frisk G, , Bjorkhem-Bergman L. Deprescribing in Palliative Cancer Care. Life (Basel), 2022; 12(5):613.","journal-title":"Life (Basel)"},{"issue":"5","key":"e_1_3_4_7_2","first-page":"596","article-title":"Blood Pressure, Orthostatic Hypotension and Falls in Patients with Advanced Cancer","volume":"115","author":"Worrall AP","year":"2022","unstructured":"Worrall AP, , Doyle CP, , N\u00ed Dhomhnall R, et al. Blood Pressure, Orthostatic Hypotension and Falls in Patients with Advanced Cancer. Ir Med J, 2022; 115(5):596.","journal-title":"Ir Med J"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-013-0219-5"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.0324"},{"issue":"3","key":"e_1_3_4_10_2","first-page":"88","article-title":"Deprescription in Advanced Cancer Patients","volume":"6","author":"Goncalves F","year":"2018","unstructured":"Goncalves F. Deprescription in Advanced Cancer Patients. Pharmacy (Basel), 2018; 6(3):88.","journal-title":"Pharmacy (Basel)"},{"key":"e_1_3_4_11_2","unstructured":"Str\u00f6m A. V\u00e4lkommen till ASIH Stockholm S\u00f6dra: Region Stockholm 2024."},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12904-019-0472-z"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.11.006"},{"key":"e_1_3_4_14_2","unstructured":"Prasantha L Vemu MEY Ebinger J. 2023 ESH Hypertension Guideline Update: Bringing Us Closer Together Across the Pond ACC-Americaln College of Cardiology 5 February 2024. 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