{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:20:51Z","timestamp":1777882851140,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurotrauma Reports"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    To evaluate the feasibility and diagnostic sensitivity of a novel catheter-based epidural electrodiagnostic (EDX) system for real-time, segment-specific monitoring of spinal somatosensory conduction in a pre-clinical model of acute spinal cord injury (SCI). A custom-designed EDX electrode catheter was epidurally placed over the thoracic spinal cord in anesthetized rats (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 5) to record compound evoked potentials across five stages: Baseline, Hypoxia, Post-SCI, Post-SCI Hypoxia, and Post-SCI Recovery. Waveform morphology, onset\/peak latencies, and amplitudes were extracted. Paired\n                    <jats:italic toggle=\"yes\">t<\/jats:italic>\n                    -tests compared baseline to experimental stages, and analysis of covariance (ANCOVA) assessed injury force effects on conduction metrics. Postmortem recordings confirmed the biological origin of signals. The EDX system consistently recorded high-fidelity biphasic spinal evoked responses. SCI induced significant increases in N-Onset latency across all post-injury stages (Cohen\u2019s\n                    <jats:italic toggle=\"yes\">d<\/jats:italic>\n                    = 2.45\u20133.04), while N-Peak and P-Peak latencies also increased significantly Post-SCI (Cohen\u2019s\n                    <jats:italic toggle=\"yes\">d<\/jats:italic>\n                    = 2.03\u20132.57), reflecting conduction slowing and partial demyelination. ANCOVA revealed that injury force had large effects on N-Onset (\u03b72\n                    <jats:sub>p<\/jats:sub>\n                    = 0.872) and P-Onset (\u03b72\n                    <jats:sub>p<\/jats:sub>\n                    = 0.492). After adjustment, group effects remained significant for N-Onset (\u03b72\n                    <jats:sub>p<\/jats:sub>\n                    = 0.799), P-Onset (\u03b72\n                    <jats:sub>p<\/jats:sub>\n                    = 0.513), and N-Peak (\u03b72\n                    <jats:sub>p<\/jats:sub>\n                    = 0.565). Although P-Peak and amplitude changes did not reach significance, their effect sizes (\u03b72\n                    <jats:sub>p<\/jats:sub>\n                    &gt; 0.06 and &gt;0.01) suggested a clinically meaningful influence. These findings support the EDX system\u2019s sensitivity to both the presence and severity of SCI. This proof-of-concept study demonstrates the feasibility and diagnostic value of an epidural EDX platform for real-time segmental monitoring of spinal conduction. The system\u2019s robust sensitivity to latency shifts and force-dependent modulation underscores its potential for intraoperative neuromonitoring, SCI diagnosis, and injury stratification. Its dorsal column targeting and catheter-based design also support integration into closed-loop neuromodulatory frameworks and longitudinal neurorehabilitation, providing a foundation for future clinical translation.\n                  <\/jats:p>","DOI":"10.1177\/2689288x251394340","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T15:10:20Z","timestamp":1763219420000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic Epidural Monitoring of Spinal Cord Neural Conduction Using a Novel Implantable Electrodiagnostic Sensor: A Pre Clinical Study"],"prefix":"10.1177","volume":"6","author":[{"given":"Babak","family":"Shadgan","sequence":"first","affiliation":[{"name":"International Collaboration on Repair Discoveries, Vancouver, Canada."},{"name":"Department of Orthopaedics, University of British Columbia, Vancouver, Canada."},{"name":"School of Biomedical Engineering, University of British Columbia, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Burden","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyn","family":"B\u00e9gin","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Lu","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahbaz","family":"Askari","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"Early acute management in adults with spinal cord injury: A clinical practice guideline for health-care professionals. 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Nerve conduction studies: Essentials and pitfalls in practice. J Neurol Neurosurg Psychiatry, 2005; 76 Suppl 2(Suppl 2):ii23\u2013ii31; doi: 10.1136\/jnnp.2005.069138","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"2","key":"e_1_3_5_8_2","first-page":"73","article-title":"Nerve conduction studies in polyneuropathy: Practical physiology and patterns of abnormality","volume":"106","author":"Franssen H","year":"2006","unstructured":"Franssen H, , van den Bergh PY. Nerve conduction studies in polyneuropathy: Practical physiology and patterns of abnormality. 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