{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T14:00:42Z","timestamp":1785074442554,"version":"3.55.0"},"reference-count":38,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"University of Mississippi Medical Center","award":["Intramural Research Support Program"],"award-info":[{"award-number":["Intramural Research Support Program"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Facial Plastic Surgery &amp; Aesthetic Medicine"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Fresh frozen costal cartilage allografts are used in rhinoplasty, but their biomechanical and biochemical properties remain under-characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine whether cut orientation, harvest location, or irradiation status influences the biochemical, mechanical, and warping properties of a commercial fresh frozen costal cartilage allograft.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Biochemical assays, three-point bending, and warping assessments were performed. Mixed-effects and linear regression models assessed associations with orientation, harvest location, and irradiation status. Intraclass correlation coefficients quantified donor-level variability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Twenty-one specimens from 9 donors (mean age 43.1 years, 78% male, 44% irradiated) yielded 66 biochemical assays, 16 bending tests, and 143 warping observations. Collagen, sulfated glycosaminoglycan (sGAG), and collagen-to-sGAG ratio did not differ between cortical and medullary cartilage (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2265 0.55). DNA was lower in medullary samples (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.02; ICC = 0.73). Elastic and flexural moduli did not differ by harvest location or irradiation status (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &gt; 0.35). Median 60-min warping angle was 8.15\u00b0 (IQR 5.76\u201311.26\u00b0). Median plateau time was 37.2 min, with 94% stabilizing within 45 min. The 15-minute warping angle was the strongest predictor of final graft geometry (coefficient 0.917,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In this study, donor-level variation tended to exceed the effects of cut orientation, harvest location, or irradiation status.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/26893614261468226","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:51:27Z","timestamp":1784868687000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Biochemical, Mechanical, and Warping Behavior of Fresh Frozen Costal Cartilage Allograft"],"prefix":"10.1177","author":[{"given":"Garner C.","family":"Fincher","sequence":"first","affiliation":[{"name":"University of Mississippi Medical Center, School of Medicine, University of Mississippi, Jackson, Mississippi, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Warren","sequence":"additional","affiliation":[{"name":"University of Mississippi Medical Center, School of Medicine, University of Mississippi, Jackson, Mississippi, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alia","family":"Tayara","sequence":"additional","affiliation":[{"name":"University of Mississippi Medical Center, School of Medicine, University of Mississippi, Jackson, Mississippi, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn D.","family":"Myatt","sequence":"additional","affiliation":[{"name":"University of Mississippi Medical Center, School of Medicine, University of Mississippi, Jackson, Mississippi, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail A.","family":"Mechatto","sequence":"additional","affiliation":[{"name":"University of Mississippi Medical Center, School of Medicine, University of Mississippi, Jackson, Mississippi, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelma","family":"Iriarte Oporto","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kush","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Abu Yusuf","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Spankovich","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall S.","family":"Williamson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Materials Science, University of Mississippi Medical Center, Jackson, Mississippi, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amol","family":"Janorkar","sequence":"additional","affiliation":[{"name":"Department of Biomedical Materials Science, University of Mississippi Medical Center, Jackson, Mississippi, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Jordan","sequence":"additional","affiliation":[{"name":"Department of 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