{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:18:08Z","timestamp":1789402688324,"version":"build-2803163510"},"reference-count":45,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K12 AR084223"],"award-info":[{"award-number":["K12 AR084223"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pediatric Hematology\/Oncology Nursing"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>Background: Chemotherapy is a common treatment in childhood cancer but causes significant side effects, among the most notable being nausea and vomiting, known as chemotherapy-induced nausea and vomiting (CINV). Pharmacological antiemetics and complementary and integrative medicine (CIM) have been studied separately to manage CINV, but a gap exists in understanding their use together. We aimed to investigate the potential multimodal effects of CIM and pharmacological antiemetics on CINV in pediatric oncology patients undergoing chemotherapy. Method: Systematic searches were conducted in four databases to identify studies evaluating the efficacy of CIM in combination with pharmacological antiemetics in patients ages 0\u201321 with cancer undergoing chemotherapy. Relevant data were extracted from each study and evaluated. Results: Eighteen sources examining CIM therapies in three distinct categories (herbal, physical, and psychological) were identified. Three of four herbal interventions yielded significant results, all of which implemented oral ginger. Physical interventions included manual and wristband acupressure, auricular acupuncture, and needle and laser acupuncture. Significant results were found in only four of these 10 studies. Among psychological interventions, two of four yielded significant results. Discussion: There is no clear evidence of benefit from CIM therapies in addition to pharmacological antiemetics to better control CINV. However, this review provides support and direction for future research to examine potential effects. Complementary therapies generally have little potential for harm, are relatively low cost, and low burden. Therefore, if there is a perceived benefit for patients and families, complementary and integrative therapies should be considered.<\/jats:p>","DOI":"10.1177\/27527530241267294","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T20:23:11Z","timestamp":1724876591000},"page":"358-369","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Use of Complementary and Integrative Medicine in Combination With Pharmacological Antiemetics to Address Chemotherapy-Induced Nausea and Vomiting in Pediatric Oncology: A Scoping Review"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6838-6992","authenticated-orcid":false,"given":"Madeleine","family":"Kajencki","sequence":"first","affiliation":[{"name":"Pediatric Hematology\/Oncology and Bone Marrow Transplant, M Health Fairview Masonic Children's Hospital, Minneapolis, MN, USA"},{"name":"School of Nursing, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Turcotte","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Oncology, M Health Fairview Masonic Children's Hospital, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Claar","sequence":"additional","affiliation":[{"name":"Pediatric Integrative Health & Wellbeing, M Health Fairview Masonic Children's Hospital, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth V.","family":"Weinfurter","sequence":"additional","affiliation":[{"name":"Health Sciences Library, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7073-3224","authenticated-orcid":false,"given":"Mary O.","family":"Whipple","sequence":"additional","affiliation":[{"name":"Adult and Gerontological Health Cooperative, School of Nursing, University of Minnesota, Minneapolis, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"bibr1-27527530241267294","doi-asserted-by":"publisher","DOI":"10.5430\/jnep.v6n4p122"},{"key":"bibr2-27527530241267294","volume-title":"Complementary and alternative medicine","author":"Centers for Disease Control and Prevention","year":"2022"},{"key":"bibr3-27527530241267294","unstructured":"Children\u2019s Oncology Group (COG). (2021).\n                      Guidelines on chemotherapy-induced nausea and vomiting in pediatric cancer patients\u2014Acute\n                      . Children\u2019s Oncology Group Supportive Care Endorsed Guidelines. https:\/\/childrensoncologygroup.org\/docs\/default-source\/pdf\/COG_SC_CINV_Acute_Document-ARCHIVED-30APRIL2021.pdf"},{"key":"bibr4-27527530241267294","volume-title":"Guidelines on chemotherapy-induced nausea and vomiting in pediatric cancer patients","author":"Children\u2019s Oncology Group (COG)","year":"2023"},{"key":"bibr5-27527530241267294","first-page":"7","volume-title":"The convergence of complementary, alternative and conventional health care: Educational resources for health professionals","author":"Curtis P. C.","year":"2004"},{"key":"bibr6-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1016\/j.jef.2015.02.007"},{"issue":"1","key":"bibr7-27527530241267294","first-page":"12785","volume":"9","author":"Damavandi S. A.","year":"2021","journal-title":"International Journal of Pediatrics"},{"key":"bibr9-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-430"},{"key":"bibr10-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31198"},{"key":"bibr11-27527530241267294","doi-asserted-by":"publisher","DOI":"10.2165\/00148581-200305090-00003"},{"key":"bibr12-27527530241267294","doi-asserted-by":"publisher","DOI":"10.3390\/children5080111"},{"key":"bibr13-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2021.102730"},{"key":"bibr14-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1177\/1043454218782133"},{"key":"bibr15-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2021.12.010"},{"key":"bibr16-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1086039"},{"key":"bibr17-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1159\/000431256"},{"key":"bibr18-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1002\/pon.2960040203"},{"key":"bibr19-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1097\/NCC.0000000000001239"},{"issue":"4","key":"bibr20-27527530241267294","first-page":"373","volume":"8","author":"Hussein H. A.","year":"2013","journal-title":"World Journal of Medical Sciences"},{"issue":"4","key":"bibr21-27527530241267294","first-page":"141","volume":"6","author":"Jones E.","year":"2018","journal-title":"Journal of the Society for Integrative Oncology"},{"key":"bibr22-27527530241267294","unstructured":"Lo L. (1998).\n                      Effects of P6 acupressure on acute and delayed nausea and vomiting in children receiving cancer chemotherapy\n                      [Doctoral dissertation]. Case Western Reserve University. UMI Microform."},{"key":"bibr23-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1177\/1043454216688638"},{"key":"bibr24-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-022-03537-w"},{"key":"bibr25-27527530241267294","unstructured":"National Cancer Institute (NCI). (2022).\n                      Chemotherapy to treat cancer\n                      . U.S. Department of Health and Human Services. https:\/\/www.cancer.gov\/about-cancer\/treatment\/types\/chemotherapy"},{"key":"bibr26-27527530241267294","volume-title":"Cancer in children and adults","author":"National Cancer Institute (NCI)"},{"key":"bibr27-27527530241267294","volume-title":"Childhood cancers","author":"National Cancer Institute (NCI)"},{"key":"bibr28-27527530241267294","volume-title":"Acupuncture (PDQ)\u2014Health professional version","author":"National Cancer Institute (NCI)"},{"key":"bibr29-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27646"},{"key":"bibr30-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007786.pub3"},{"key":"bibr31-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22778"},{"key":"bibr32-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1177\/1043454206296027"},{"key":"bibr33-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-005-0846-z"},{"key":"bibr34-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002225"},{"key":"bibr35-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1177\/0300060518765324"},{"key":"bibr36-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1089\/cpb.1999.2.125"},{"key":"bibr37-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2022.102121"},{"key":"bibr38-27527530241267294","volume-title":"The effect of complementary therapies on the treatment of chemotherapeutic induced nausea and vomiting: A scoping review","author":"Sickel K.","year":"2018"},{"key":"bibr39-27527530241267294","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"bibr40-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1177\/1043454218810140"},{"key":"bibr41-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0258514"},{"key":"bibr42-27527530241267294","first-page":"1","volume":"61","author":"Wong C. L.","year":"2022","journal-title":"European Journal of Oncology Nursing"},{"key":"bibr43-27527530241267294","volume-title":"Childhood cancer","author":"World Health Organization","year":"2021"},{"key":"bibr44-27527530241267294","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2011.0102"},{"issue":"6","key":"bibr45-27527530241267294","first-page":"13","volume":"7","author":"Yousef Y.","year":"2018","journal-title":"IOSR Journal of Nursing and Health Science"},{"issue":"1","key":"bibr46-27527530241267294","first-page":"67","volume":"7","author":"Yuliar T. P.","year":"2019","journal-title":"Padjadjaran Nursing Journal"}],"container-title":["Journal of Pediatric Hematology\/Oncology Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/27527530241267294","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/27527530241267294","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/27527530241267294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:34:12Z","timestamp":1777509252000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/27527530241267294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,28]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1177\/27527530241267294"],"URL":"https:\/\/doi.org\/10.1177\/27527530241267294","relation":{},"ISSN":["2752-7530","2752-7549"],"issn-type":[{"value":"2752-7530","type":"print"},{"value":"2752-7549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,28]]}}}