{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T07:13:27Z","timestamp":1788160407796,"version":"build-2803163510"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education Malaysia","doi-asserted-by":"crossref","award":["FRGS\/1\/2020\/SKK0\/USM\/03\/9"],"award-info":[{"award-number":["FRGS\/1\/2020\/SKK0\/USM\/03\/9"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Allergy and Rhinology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    Allergic rhinitis (AR) is among the most prevalent allergic diseases in the world and has a large impact on quality of life, school performance, and work productivity. The aim of this exploratory study was to identify the genetic variants that might be associated with AR in the Malaysian population through whole-exome sequencing. A total of 13 AR patients and 10 healthy controls were recruited from the ENT Clinic at the Pusat Kanser Tun Abdullah Ahmad Badawi and Universiti Sains Malaysia Specialist Hospital. Whole-exome sequencing of genomic DNA was performed. To prioritize the variants, bioinformatic analysis was performed according to the American College of Medical Genetics (ACMG) guidelines, and potentially pathogenic variants were looked for. The 5 HLA-DRB1 variants identified (rs1059582, rs17882084, rs17879995, rs11554463, and rs188617679) were classified as potentially pathogenic or likely pathogenic, using ACMG criteria. Of these, rs1059582 had a statistically significant association with AR (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .0457), which implies that it may be involved in susceptibility to AR. The present preliminary exploratory study revealed that a number of HLA-DRB1 variants, especially HLA-DRB1 rs1059582, are candidate genetic risk factors for AR in the Malaysian population. These results are preliminary and suggest that HLA-DRB1 may be a potential biomarker, but needs to be further validated in larger cohorts.\n                  <\/jats:p>","DOI":"10.1177\/27534030261483845","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:09:37Z","timestamp":1787843377000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Variants in Allergic Rhinitis Identified by Whole-Exome Sequencing in the Malaysian Population"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2967-2201","authenticated-orcid":false,"given":"Moath","family":"Bseiso","sequence":"first","affiliation":[{"name":"Universiti Sains Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Farid","family":"Baharin","sequence":"additional","affiliation":[{"name":"National Institute of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Yusri","family":"Musa","sequence":"additional","affiliation":[{"name":"Universiti Sains Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5369-2707","authenticated-orcid":false,"given":"Sarina","family":"Sulong","sequence":"additional","affiliation":[{"name":"Universiti Sains Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saharuddin Bin","family":"Mohamad","sequence":"additional","affiliation":[{"name":"University of Malaya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9138-9215","authenticated-orcid":false,"given":"Baharudin","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Universiti Sains Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5690-8008","authenticated-orcid":false,"given":"Adiratna","family":"Mat Ripen","sequence":"additional","affiliation":[{"name":"National Institute of Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2310-6767","authenticated-orcid":false,"given":"Siti Mardhiana Binti","family":"Mohamad","sequence":"additional","affiliation":[{"name":"Universiti Sains Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2011.1.3.157"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.15367.1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43163-022-00361-4"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019719"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.7.3853"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70073-8"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-018-0280-7"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08494"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.02.022"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49782-0"},{"issue":"1","key":"e_1_3_3_12_2","first-page":"7983236","article-title":"A survey of computational tools to analyze and interpret whole exome sequencing data","volume":"2016","author":"Hintzsche JD","year":"2016","unstructured":"Hintzsche JD, Robinson WA, Tan AC. A survey of computational tools to analyze and interpret whole exome sequencing data. Int J Genomics. 2016; 2016(1): 7983236.","journal-title":"Int J Genomics."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2019.100038"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.499"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.789684"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.4314\/ajcem.v23i2.2"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051127"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.598665"},{"key":"e_1_3_3_19_2","first-page":"153","article-title":"Epigenetics and the environment in airway disease: asthma and allergic rhinitis","author":"Long A","year":"2020","unstructured":"Long A, Bunning B, Sampath V, et al. Epigenetics and the environment in airway disease: asthma and allergic rhinitis. In: Epigenetics in Allergy and Autoimmunity. Advances in Experimental Medicine and Biology, Vol. 1253. Springer, 2020, 153\u2013181.","journal-title":"Epigenetics in Allergy and Autoimmunity. Advances in Experimental Medicine and Biology"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0157-1"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.08.003"},{"key":"e_1_3_3_22_2","doi-asserted-by":"crossref","unstructured":"Zhao Y Zhao Y Zhang Y Zhang L. (eds). HLA-II genes are associated with outcomes of specific immunotherapy for allergic rhinitis. 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