{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:30:37Z","timestamp":1777645837006,"version":"3.51.4"},"reference-count":55,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Connor Foundation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Advances in Integrative Medicine and Health"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several clinical trials support the efficacy of Whole Systems Traditional Chinese Medicine (WS-TCM) modalities, including acupuncture, for improving outcomes among women undergoing in vitro fertilization (IVF), but few studies have described its real-world integration within an academic medical setting or its immediate effects on pain, stress, and anxiety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the clinical delivery of WS-TCM and assess its effects on patient-reported outcomes (PROs) among patients receiving WS-TCM while undergoing IVF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review of patients who received \u22651 WS-TCM treatment associated with \u22651 embryo transfer at a single center was conducted. A linear mixed model adjusting for the random effect of patients seen over multiple treatments was used to calculate PRO changes among those with pre-treatment PROs \u22651 on a 0-10 numeric rating scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>1896 WS-TCM treatments were provided during 202 embryo transfers among 146 patients. Patients (mean age 35.76 \u00b1 4.37) were predominantly white (79.5%), and 26.7% had a documented mental health diagnosis. Of the 202 embryo transfers, 64.9% included pre-transfer treatment, 88.6% included day-of-transfer treatment, and 32.2% included post-transfer treatment. Patients reporting pre-treatment PROs \u22651 reported clinically significant mean [95% CI] reductions in pain (\u22121.38 [\u22121.70, \u22121.07]), stress (\u22122.11 [\u22122.47, \u22121.74]), and anxiety (\u22122.22 [\u22122.63, \u22121.81]) within a single treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study supports the integration of WS-TCM within IVF and its benefits for reducing acute pain, stress, and anxiety. WS-TCM may improve patient experiences and be a useful treatment for psychosocial concerns that often accompany IVF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/27536130251349116","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T02:29:47Z","timestamp":1750818587000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Delivery of Whole Systems Traditional Chinese Medicine and Impacts Upon Patient Reported Outcomes During IVF"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8529-7402","authenticated-orcid":false,"given":"Rebecca","family":"Lu","sequence":"first","affiliation":[{"name":"Case Western Reserve University"},{"name":"School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-253X","authenticated-orcid":false,"given":"Samuel N.","family":"Rodgers-Melnick","sequence":"additional","affiliation":[{"name":"University Hospitals of Cleveland"},{"name":"Case Western Reserve University"},{"name":"School of Medicine"},{"name":"Case Western Reserve University"},{"name":"School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Flyckt","sequence":"additional","affiliation":[{"name":"Case Western Reserve University"},{"name":"School of Medicine"},{"name":"University Hospitals of Cleveland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"University Hospitals of Cleveland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roshini","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"University Hospitals of Cleveland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9581-0564","authenticated-orcid":false,"given":"Jeffery A.","family":"Dusek","sequence":"additional","affiliation":[{"name":"University of California Irvine"},{"name":"University of California Irvine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine M.","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Case Western Reserve University"},{"name":"School of Medicine"},{"name":"University Hospitals of Cleveland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,6,4]]},"reference":[{"key":"e_1_3_7_2_2","unstructured":"CDC. 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