{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:47:08Z","timestamp":1792000028022,"version":"4.4.0"},"reference-count":57,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Central Council for Research in Ayurvedic Sciences (CCRAS), Ministry of Ayush, Government of India"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Advances in Integrative Medicine and Health"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Obesity is a medical condition characterized by the excessive accumulation of body fat, which adversely impacts health. It is primarily caused by a combination of overeating, physical inactivity, and genetic predisposition. In Ayurveda, obesity corresponds to conditions such as\n                      <jats:italic toggle=\"yes\">Sthaulya<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Medoroga<\/jats:italic>\n                      . Ayurvedic formulations like\n                      <jats:italic toggle=\"yes\">Vyoshadi Guggulu<\/jats:italic>\n                      (VSG) and\n                      <jats:italic toggle=\"yes\">Vidanga Churna<\/jats:italic>\n                      (VDC) are commonly prescribed for managing obesity despite limited scientific validation. This study aimed to evaluate the safety and efficacy of VSG and VDC in individuals with obesity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, open-label, multicenter clinical study was conducted at 2 peripheral centres of the Central Council for Research in Ayurvedic Sciences (CCRAS). A total of 100 obese patients who met the selection criteria were recruited from outpatient departments and administered VSG (1 gm thrice daily after meals with lukewarm water) and VDC (3 gm twice daily after meals) for 12\u00a0weeks. Participants were followed up for an additional 2 weeks without medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Statistically significant improvements were observed in key symptoms, including polyphagia, polydipsia, excessive sweating, excessive sleep, body fatigue, and dyspnea on exertion (DOE), which was initially reported by 36 participants but reduced markedly over the study period. While most participants had moderate physical activity capacity (\n                      <jats:italic toggle=\"yes\">Vyayama Shakti<\/jats:italic>\n                      ), some experienced exertional breathlessness, which improved with intervention. Significant reductions were also noted in BMI (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.016), waist circumference (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.043), and serum cholesterol levels (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002), with no adverse drug reactions reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that the combination of VSG and VDC is effective and safe for managing obesity. Statistically significant improvements in anthropometric parameters and clinical symptoms highlight the potential of these Ayurvedic formulations as complementary therapies for obesity management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/27536130251356447","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T10:04:35Z","timestamp":1751450675000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Safety and Efficacy of Ayurveda Multi-Herbal Formulation in the Management of Obesity"],"prefix":"10.1177","volume":"14","author":[{"given":"Sanjay Kumar","family":"Giri","sequence":"first","affiliation":[{"name":"Central Ayurveda Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi Kant","family":"Vedi","sequence":"additional","affiliation":[{"name":"Regional Ayurveda Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashidhar","family":"Doddamani","sequence":"additional","affiliation":[{"name":"Central Ayurveda Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghavendra","family":"Naik","sequence":"additional","affiliation":[{"name":"Central Ayurveda Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Sharma","sequence":"additional","affiliation":[{"name":"Central Ayurveda Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishor","family":"Gavali","sequence":"additional","affiliation":[{"name":"Regional Ayurveda Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhagwan Sahai","family":"Sharma","sequence":"additional","affiliation":[{"name":"Central Council for Research in Ayurvedic Sciences (CCRAS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Khanduri","sequence":"additional","affiliation":[{"name":"Central Council for Research in Ayurvedic Sciences (CCRAS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9685-5788","authenticated-orcid":false,"given":"Bidhan","family":"Mahajon","sequence":"additional","affiliation":[{"name":"All India Institute of Ayurveda (AIIA)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunabh","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Central Council for Research in Ayurvedic Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh Kumar","family":"Rana","sequence":"additional","affiliation":[{"name":"Central Council for Research in Ayurvedic Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhogavalli Chandra Sekhara","family":"Rao","sequence":"additional","affiliation":[{"name":"Central Council for Research in Ayurvedic Sciences (CCRAS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayanam","family":"Srikanth","sequence":"additional","affiliation":[{"name":"Central Council for Research in Ayurvedic Sciences (CCRAS)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5916.164234"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60460-8"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-014-0243-x"},{"key":"e_1_3_7_5_2","volume-title":"Charaka samhita: agnivesa\u2019s treatise on Ayurveda: Chikitsa Sthana","author":"Sharma PV","year":"2011","unstructured":"Sharma PV. 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