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Twenty-five (86.2%) participants reported that they would be\n                      <jats:italic toggle=\"yes\">likely<\/jats:italic>\n                      or\n                      <jats:italic toggle=\"yes\">extremely likely<\/jats:italic>\n                      to enroll in this study, given the experience they had in the study. All participants randomized to WBH correctly believed they received WBH, and 6 (43%) of participants randomized to sham WBH correctly believed they received sham WBH. Both arms achieved clinically meaningful and statistically significant reductions in depression symptoms. The average decreases in the Beck Depression Inventory-II (BDI-II) were \u221219.07 (SE = 2.69,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001) in the WBH arm (80.0% no longer meeting DSM-5 criteria, 60.0% achieving 50% or greater reduction in BDI-II) and \u221221.10 (SE = 2.41,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.0001) in the sham WBH arm (92.9% no longer meeting DSM-5 criteria, 78.6% achieving 50% or greater reduction in BDI-II).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Study procedures were acceptable. Participants in the WBH and sham WBH groups had substantial reductions in depressive symptoms that were greater than typically seen with CBT alone. The sham WBH arm was not fully credible and may have exerted antidepressant effects, thus raising concerns about its use in future trials. Further research to test whether adding WBH to CBT results in additional antidepressant effects is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/27536130251387714","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T16:00:27Z","timestamp":1761148827000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A Randomized Trial Testing a Novel Mind and Body Intervention for Depression: Cognitive Behavioral Therapy (CBT) and Whole-Body Hyperthermia (WBH)"],"prefix":"10.1177","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8744-0185","authenticated-orcid":false,"given":"Ashley E.","family":"Mason","sequence":"first","affiliation":[{"name":"University of California, San Francisco (UCSF)"},{"name":"University of California San Francisco (UCSF)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Hartogensis","sequence":"additional","affiliation":[{"name":"University of California, San Francisco (UCSF)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoushka","family":"Chowdhary","sequence":"additional","affiliation":[{"name":"University of Arizona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1417-8582","authenticated-orcid":false,"given":"Chelsea J.","family":"Siwik","sequence":"additional","affiliation":[{"name":"Cleveland Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena S.","family":"Pandya","sequence":"additional","affiliation":[{"name":"University of California, San Francisco (UCSF)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Jung","sequence":"additional","affiliation":[{"name":"University of California, San Francisco (UCSF)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osnat","family":"Lupesko-Persky","sequence":"additional","affiliation":[{"name":"University of California, San Francisco (UCSF)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Hartley","sequence":"additional","affiliation":[{"name":"University of California, San Francisco (UCSF)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Hopkins","sequence":"additional","affiliation":[{"name":"University of California, San Francisco (UCSF)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Roberts","sequence":"additional","affiliation":[{"name":"University of California, San Francisco (UCSF)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Borovinsky","sequence":"additional","affiliation":[{"name":"University of California, San Francisco (UCSF)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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