{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:31:35Z","timestamp":1777645895557,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Advances in Integrative Medicine and Health"],"published-print":{"date-parts":[[2026,1,16]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiodermatitis is a common skin injury in patients undergoing radiotherapy, especially in cases of head and neck cancer, and may impair treatment adherence and the patient\u2019s quality of life. Therefore, the search for effective and low-cost interventions for the prevention and management of radiodermatitis is essential. In this context, Calendula- and Chamomile-based creams have been considered in oncological care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the effectiveness of topical Calendula and Chamomile creams in the prevention and treatment of radiodermatitis in head and neck cancer patients undergoing radiotherapy combined with chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a protocol for a randomized, controlled, triple-blind clinical trial employing a quantitative approach. The protocol adheres to the guidelines advocated by the Consolidated Standards of Reporting Trials (CONSORT) 2025 and the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) 2025. A total of 99 participants will be randomly allocated into 3 groups. Data will be collected using a four-section instrument and analyzed with Microsoft Office Excel and Statistical Package for Social Sciences (SPSS) version 20.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study aims to validate the effectiveness of Calendula and Chamomile creams in controlling radiodermatitis and to identify the most efficient option for preventing adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings are expected to underscore the necessity of promoting and implementing systematic, scientifically grounded protocols in oncological patient care, emphasizing a humanized approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial and Protocol Registration<\/jats:title>\n                    <jats:p>\n                      Brazilian Registry of Clinical Trials (ReBEC), RBR-8gxt823,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/ensaiosclinicos.gov.br\/rg\/RBR-8gxt823\">https:\/\/ensaiosclinicos.gov.br\/rg\/RBR-8gxt823<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/27536130251405244","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T05:38:37Z","timestamp":1768628317000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Use of Topical Calendula and Chamomile Creams for the Management of Radiodermatitis in Cancer Patients: A Randomized Clinical Trial Protocol"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6481-2150","authenticated-orcid":false,"given":"T\u00e2mara Taynah Medeiros da","family":"Silva","sequence":"first","affiliation":[{"name":"Federal University of Rio Grande Do Norte"},{"name":"Liga Norte Rio Grandense Contra o C\u00e2ncer"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4679-1840","authenticated-orcid":false,"given":"Kauanny Vitoria Gurgel dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande Do Norte"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9440-4886","authenticated-orcid":false,"given":"Guilherme Moises Alves","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande Do Norte"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0827-8925","authenticated-orcid":false,"given":"Danielle de Oliveira","family":"Rocha","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande Do Norte"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7935-0666","authenticated-orcid":false,"given":"Lara Dantas de Rubim","family":"Costa","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande Do Norte"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4105-7535","authenticated-orcid":false,"given":"Kleyton Santos de","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Liga Norte Rio Grandense Contra o C\u00e2ncer"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3513-7483","authenticated-orcid":false,"given":"K\u00e1tia Regina Barros","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande Do Norte"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0307-2424","authenticated-orcid":false,"given":"Daniele Vieira","family":"Dantas","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande Do Norte"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9309-2092","authenticated-orcid":false,"given":"Rodrigo Assis Neves","family":"Dantas","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande Do Norte"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_3_7_2_2","volume-title":"Estimate 2023: Cancer Incidence in Brazil","author":"National Cancer Institute Jos\u00e9 Alencar Gomes da Silva (INCA)","unstructured":"National Cancer Institute Jos\u00e9 Alencar Gomes da Silva (INCA). 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