{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T08:01:36Z","timestamp":1780128096967,"version":"3.54.0"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Global Advances in Integrative Medicine and Health"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Alzheimer\u2019s disease (AD) and related dementias remain major public health challenges with limited treatment options. Personalized, multimodal integrative approaches have emerged as potential strategies for patients with mild cognitive impairment (MCI) and early-stage AD.\n                    <jats:bold>Purpose:<\/jats:bold>\n                    To describe outcomes from the first 51 participants enrolled in an academic integrative functional medicine program for cognitive decline.\n                    <jats:bold>Research Design:<\/jats:bold>\n                    Retrospective case series, chart analysis.\n                    <jats:bold>Study Sample:<\/jats:bold>\n                    Participants with MCI or AD enrolled at the GW Center for Integrative Medicine (n=51, 2017-2025); 22 remained in the program for \u22652.5 years for long-term cognitive analyses.\n                    <jats:bold>Data Collection and\/or Analysis:<\/jats:bold>\n                    Participants underwent serial cognitive assessments [Montreal Cognitive Assessment (MoCA) and\/or Boston Cognitive Assessment (BOCA), subset also completing CNS-Vitals and SLAMs at variable intervals]. MoCA was the prespecified primary outcome. Interventions included dietary modification, time-restricted eating, exercise, cognitive training, sleep optimization, individualized supplementation, hormonal management, and 40 Hz gamma-frequency sensory stimulation. Exploratory measures included volumetric brain MRI and Alzheimer's blood biomarkers (A\u03b242\/A\u03b240, p-tau217, NfL) in a subset. Outcomes were summarized descriptively without formal statistical analyses.\n                    <jats:bold>Results:<\/jats:bold>\n                    Among participants with \u22652.5 years of follow-up, mean MoCA increased from 21.7 to 22.5, and 73% (16\/22) demonstrated improvement (\u22652-point increase) or stabilization (\u22121 to +1 points). Attrition was high; 29\/51 discontinued within the first year, most commonly due to cost, program complexity, and lack of caregiver support.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    This program demonstrated encouraging preliminary findings of cognitive stabilization or improvement in participants with MCI or AD who remained enrolled. Controlled prospective trials are needed to determine efficacy and mechanisms.\n                  <\/jats:p>","DOI":"10.1177\/27536130261452680","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:04:26Z","timestamp":1779915866000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Integrative Personalized Functional Medicine Approach to Reverse Cognitive Decline: Academic Experience of the First 51 Patients Case Series"],"prefix":"10.1177","volume":"15","author":[{"given":"Mikhail","family":"Kogan","sequence":"first","affiliation":[{"name":"The George Washington University School of Medicine and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1475-2778","authenticated-orcid":false,"given":"Leigh A.","family":"Frame","sequence":"additional","affiliation":[{"name":"GW Center for Integrative Medicine"},{"name":"The George Washington University School of Medicine and Health Sciences"},{"name":"The George Washington University School of Medicine and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrshad","family":"Fahim Devin","sequence":"additional","affiliation":[{"name":"The George Washington University School of Medicine and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Prather","sequence":"additional","affiliation":[{"name":"The George Washington University School of Medicine and Health Sciences"},{"name":"George Washington University Medical Faculty Associates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Alchalabi","sequence":"additional","affiliation":[{"name":"The George Washington University School of Medicine and Health Sciences"},{"name":"George Washington University Medical Faculty Associates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umair","family":"Ashraf","sequence":"additional","affiliation":[{"name":"George Washington University Medical Faculty Associates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna","family":"Darling Luczak","sequence":"additional","affiliation":[{"name":"Nova Physician Wellness Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Fine","sequence":"additional","affiliation":[{"name":"GW Center for Integrative Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajowa","family":"Ifateyo","sequence":"additional","affiliation":[{"name":"GW Center for Integrative Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Ledenac","sequence":"additional","affiliation":[{"name":"GW Center for Integrative Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara \u201cSally\u201d","family":"Novak","sequence":"additional","affiliation":[{"name":"GW Center for Integrative Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonah","family":"Yakel","sequence":"additional","affiliation":[{"name":"GW Center for Integrative Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4172\/2161-0460.1000450"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD215707"},{"key":"e_1_3_3_4_2","unstructured":"LPWell. Dementia reversal trial: ReCODE randomized clinical trial. 2023. 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Apollo Health; 2023. https:\/\/www.apollohealthco.com\/recode-protocol. Accessed April 29, 2025."},{"key":"e_1_3_3_15_2","volume-title":"General guidelines for the patient undergoing removal of mercury-amalgam fillings","author":"Lerner DL","unstructured":"Lerner DL. General guidelines for the patient undergoing removal of mercury-amalgam fillings. Yorktown Heights, NY: The Center for Holistic Dentistry. [cited 2025 Aug 18]. Available from. https:\/\/holisticdentist.com\/wp-content\/uploads\/2020\/03\/General-Guidelines-for-the-Patient-Undergoing-Removal-of-Mercury-Amalgam-Fillings.pdf"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000002718"},{"key":"e_1_3_3_17_2","volume-title":"Multi-Sensory Gamma Stimulation Ameliorates Alzheimer\u2019s-associated Pathology and Improves Cognition","author":"AlzLife","year":"2019","unstructured":"AlzLife. Multi-Sensory Gamma Stimulation Ameliorates Alzheimer\u2019s-associated Pathology and Improves Cognition. AlzLife; 2019. https:\/\/www.alz.life\/gamma-news\/multi-sensory-gamma-stimulation-ameliorates-alzheimers-associated-pathology-and-improves-cognition\/"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11142040"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0278412"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.1095081"},{"key":"e_1_3_3_21_2","volume-title":"BrainHQ Exercises","author":"Posit Science","year":"2023","unstructured":"Posit Science. BrainHQ Exercises. 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