{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:25:02Z","timestamp":1777883102757,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031013","name":"fralin biomedical research institute, virginia polytechnic institute and state university","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Advances in Rehabilitation Science and Practice"],"published-print":{"date-parts":[[2024,1]]},"abstract":"\n Objective:<\/jats:title>\n To report practice based evidence built on clinical findings where an intensive therapeutic approach called ACQUIRE Therapy was used as a rehabilitation\/habilitation tool for children diagnosed with CASK mutations. ACQUIRE Therapy delivery is based on principles of learning and guided by a therapeutic framework often used in the delivery of intensive therapy.<\/jats:p>\n <\/jats:sec>\n \n Design:<\/jats:title>\n Clinical Cohort.<\/jats:p>\n <\/jats:sec>\n \n Setting:<\/jats:title>\n Natural environments (eg, home-like environment).<\/jats:p>\n <\/jats:sec>\n \n Participants:<\/jats:title>\n A total of 20 females, 12 to 128\u2009months, mean age\u2009=\u200944.75 (SD\u2009=\u200931.64).<\/jats:p>\n <\/jats:sec>\n \n Intervention:<\/jats:title>\n Trained Occupational therapists delivered high-dosage rehabilitation for an average of 64.06\u2009hours (SD\u2009=\u200912.91) across 4\u2009weeks. ACQUIRE Therapy targeted cross-domain intervention targets often associated with executive control and praxis.<\/jats:p>\n <\/jats:sec>\n \n Main outcome measures:<\/jats:title>\n Clinical data was examined from the following sources; therapist daily treatment documentation (eg, therapy goals, video recordings, daily therapy logs, and discharge documentation).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Receptive communication improved in all children. The most common motor skill improvements occurred in trunk control occurring in 33% of children; followed by, gross reaching abilities in 21% of children; fine-motor skills in 19%; head control in 15%; and mobility in 12%. Documentation of cognitive-motor pairing of skills was documented in all children.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Diagnosis specific intervention targets (eg, attention and cognitive-pairing skills) need to be considered when providing therapeutic services to children with CASK-gene mutations and other forms of Global Developmental Delay. Clinicaltrials.gov registration number is NCT03325946. Date of registration: 1 May 2013. Trial Dates: December 2014 and October 2023. https:\/\/clinicaltrials.gov\/study\/NCT03325946?locStr=Roanoke,%20VA&country=United%20States&state=Virginia&city=Roanoke&cond=Cerebral%20Palsy&intr=Intensive%20therapy&rank=2<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/27536351241302852","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T01:35:27Z","timestamp":1732757727000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical use of ACQUIRE Therapy for Children Diagnosed With CASK-Gene Related Disabilities"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7466-569X","authenticated-orcid":false,"given":"Dory A","family":"Wallace","sequence":"first","affiliation":[{"name":"Fralin Biomedical Research Institute, Virginia Tech, Roanoke, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Rebekah Trucks","sequence":"additional","affiliation":[{"name":"Fralin Biomedical Research Institute, Virginia Tech, Roanoke, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie C","family":"DeLuca","sequence":"additional","affiliation":[{"name":"Fralin Biomedical Research Institute, Virginia Tech, Roanoke, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"bibr1-27536351241302852","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.60687"},{"key":"bibr2-27536351241302852","doi-asserted-by":"publisher","DOI":"10.1038\/ng.194"},{"key":"bibr3-27536351241302852","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31400"},{"key":"bibr4-27536351241302852","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-017-3065-z"},{"key":"bibr5-27536351241302852","volume-title":"An Efficacious Therapy for Treating Children With CASK Mutations: Combining Lessons From an Animal Model to a Clinical Setting","volume":"2016","author":"DeLuca S"},{"key":"bibr6-27536351241302852","volume-title":"GeneReviews","author":"Moog U"},{"key":"bibr7-27536351241302852","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.220"},{"key":"bibr8-27536351241302852","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-016-0295-6"},{"key":"bibr9-27536351241302852","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-033878"},{"key":"bibr10-27536351241302852","volume-title":"Handbook of Clinical Neurology","volume":"2020","author":"Hallemans A"},{"key":"bibr11-27536351241302852","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2016.10.010"},{"key":"bibr12-27536351241302852","first-page":"553","volume-title":"Encyclopedia of Neuroscience","volume":"2009","author":"Buxbaum LJ"},{"key":"bibr13-27536351241302852","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2017.01.014"},{"key":"bibr14-27536351241302852","first-page":"167","volume-title":"Blackwell handbook of early childhood development","volume":"2006","author":"Welsh MC"},{"key":"bibr15-27536351241302852","doi-asserted-by":"publisher","DOI":"10.1037\/dev0001127"},{"key":"bibr16-27536351241302852","doi-asserted-by":"publisher","DOI":"10.1002\/dev.21982"},{"key":"bibr17-27536351241302852","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2020.02208"}],"container-title":["Advances in Rehabilitation Science and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/27536351241302852","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/27536351241302852","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/27536351241302852","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:33:56Z","timestamp":1777599236000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/27536351241302852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":17,"alternative-id":["10.1177\/27536351241302852"],"URL":"https:\/\/doi.org\/10.1177\/27536351241302852","relation":{},"ISSN":["2753-6351","2753-6351"],"issn-type":[{"value":"2753-6351","type":"print"},{"value":"2753-6351","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"27536351241302852"}}