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It may be a source of major alterations in quality of life, and it represents substantial costs for health care systems and society.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This research aims at exploring, in vulnerable persons living with chronic conditions, the relation between pain intensity and: (1) socio-demographic variables; (2) sedentary behaviour and physical exercise and (3) quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>The EFFICHRONIC intervention is part of the Third EU Health Programme. It consisted of implementing the Chronic Disease Self-Management Programme in five European regions (in France, Italy, Spain, the Netherlands and the United Kingdom).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Adjusting for a wide range of variables in multivariable regressions and using multiple imputation methods, we examined the associations between the intensity of pain and the other variables of interest in a large sample (1364 participants).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>These analyses showed that women had more intense pain, as well as participants with a lower education level. The pain was, among all variables, the main predictor of sleep problems, fatigue, depression, self-perceived health and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our results confirmed the importance of the social component in the complex aetiology of pain, and reinforced the idea that the recognition of the social determinants of health is essential. They are also in line with other studies showing the major impact of pain on an individual\u2019s health and life. Decreasing social inequalities and vulnerability could clearly reduce the prevalence of pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>The study was registered at ISRCTN \u2013 The UK\u2019s Clinical Study Registry (70517103).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/27558428251336656","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T08:12:31Z","timestamp":1775549551000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pain in vulnerable people with chronic conditions: a multicentric cross-sectional study"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3055-7494","authenticated-orcid":false,"given":"Charlotte","family":"Faurie","sequence":"first","affiliation":[{"name":"CNRS, Institute for Evolutionary Sciences, University of Montpellier, Montpellier, France"},{"name":"Department of Primary Care, School of Medicine, University of Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Duflos","sequence":"additional","affiliation":[{"name":"Institut Desbrest d\u2019Epid\u00e9miologie et de Sant\u00e9 Public, UMR UA11 INSERM, Universit\u00e9 de Montpellier, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liset","family":"Elstgeest","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands"},{"name":"Reinier Academy, Reinier de Graaf Hospital, Delft, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna","family":"Ferreira","sequence":"additional","affiliation":[{"name":"IRMB, University of Montpellier, INSERM, CHU Montpellier, Montpellier, France"},{"name":"Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hein","family":"Raat","sequence":"additional","affiliation":[{"name":"Department of Public Health, Erasmus MC University Medical Center, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8271-2826","authenticated-orcid":false,"given":"Verushka","family":"Valsecchi","sequence":"additional","affiliation":[{"name":"IRMB, University of Montpellier, INSERM, CHU Montpellier, Montpellier, France"},{"name":"Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, Lapeyronie University Hospital, Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8615-1955","authenticated-orcid":false,"given":"Alberto","family":"Pilotto","sequence":"additional","affiliation":[{"name":"Department of Geriatric Care, Orthogeriatrics and Rehabilitation, E.O. 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