{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:27:25Z","timestamp":1787750845626,"version":"build-2784847793"},"reference-count":45,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative and Complementary Medicine"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>India bears a heavy burden of iron deficiency anemia (IDA), affecting nearly 50% of the population and contributing to adverse pregnancy outcomes, accounting for 20% of maternal deaths. While IDA continues to be a major health issue in India, there is a lack of comparative data on the efficacy of Ayurvedic treatments. This review aims to fill this evidence gap by systematically evaluating and ranking the efficacy of different Ayurvedic treatments for IDA using network meta-analysis (NMA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A systematic search was undertaken on May 1, 2024 using MEDLINE (via PubMed), Scopus, ScienceDirect, AYUSH Research Portal, and Google Scholar to locate randomized controlled trial (RCTs) evaluating interventions and their impact on hemoglobin (Hb) and serum ferritin. We conducted a random-effects NMA using a frequentist framework to estimate the mean difference (MD) and 95% confidence intervals (CIs) for the effects of interventions on outcomes, accounting for heterogeneity (\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Nineteen RCTs, comprising 2,121 individuals, assessed 26 different treatments for IDA and met the eligibility criteria. Results from the reference-based forest plots of the sensitivity analysis and corresponding P-scores revealed that both Sarva-Jvara-Hara-Lauha (SJHL) and Pippalyadi Yoga demonstrated statistically significant improvements in Hb levels, with MDs of 1.82 g\/dL (95% CI: 0.66\u20132.98) and 1.45 g\/dL (95% CI: 1.21\u20131.69), respectively. Among the interventions, Bibhitakadi Vatak demonstrated strong effectiveness in raising serum ferritin levels (MD: 3.87 ng\/mL; 95% CI: \u221213.32\u201321.06).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>SJHL and Bibhitakadi Vatak were found to be the most effective strategies for treating IDA. Additional research is needed to substantiate these findings and assess their wider impact on public health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration:<\/jats:title>\n                    <jats:p>PROSPERO registration number CRD42024541803.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/27683605251387011","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:41:37Z","timestamp":1760542897000},"page":"143-150","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Ayurvedic Interventions on Iron Deficiency Anemia in India: A Systematic Review and Network Meta-Analysis"],"prefix":"10.1177","volume":"32","author":[{"given":"Yadu","family":"Damodaran","sequence":"first","affiliation":[{"name":"Department of Health Systems Research, ICMR - National Institute of Traditional Medicine, Nehru Nagar, Belagavi, Karnataka, India."},{"name":"Department of Biostatistics, St. Thomas College, Palai, Kerala, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalesh Mappilakudy","family":"Karun","sequence":"additional","affiliation":[{"name":"Department of Health Systems Research, ICMR - National Institute of Traditional Medicine, Nehru Nagar, Belagavi, Karnataka, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flemin","family":"Felix","sequence":"additional","affiliation":[{"name":"Department of Health Systems Research, ICMR - National Institute of Traditional Medicine, Nehru Nagar, Belagavi, Karnataka, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandan","family":"Nagendraswamy","sequence":"additional","affiliation":[{"name":"Department of Health Systems Research, ICMR - National Institute of Traditional Medicine, Nehru Nagar, Belagavi, Karnataka, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepthy Melepurakkal","family":"Sadanandan","sequence":"additional","affiliation":[{"name":"Women\u2019s &amp; Children\u2019s Health Research Unit, Jawaharlal Nehru Medical College of KLE, Academy of Higher Education and Research (KAHER), Belagavi, Karnataka, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Barvaliya","sequence":"additional","affiliation":[{"name":"Department of Health Systems Research, ICMR - National Institute of Traditional Medicine, Nehru Nagar, Belagavi, Karnataka, India."},{"name":"Department of Health Research (Govt. of India), Model Rural Health Research Unit, Sirwar, Karnataka, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subarna","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Health Systems Research, ICMR - National Institute of Traditional Medicine, Nehru Nagar, Belagavi, Karnataka, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"e_1_3_5_2_2","unstructured":"Institute for Health Metrics and Evaluation. New study reveals global anemia cases remain persistently high among women and children. Anemia rates decline for men. The Lancet; 2023. Available from: https:\/\/www.healthdata.org\/news-events\/newsroom\/news-releases\/lancet-new-study-reveals-global-anemia-cases-remain-persistently"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu16111673"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114522000927"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40985-020-00125-6"},{"key":"e_1_3_5_6_2","unstructured":"Press Information Bureau. Anaemia Mukt Bharat; 2022. Available from: https:\/\/pib.gov.in\/PressReleasePage.aspx?PRID=1795421"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-025-22439-3"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s41182-019-0165-6"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_3_5_10_2","first-page":"2","volume-title":"Revised Cochrane risk-of-bias tool for randomized trials","author":"Higgins J","year":"2019","unstructured":"Higgins J, , Savovic J, , Page M, , Sterne J. Revised Cochrane risk-of-bias tool for randomized trials. London: The Cochrane Collaboration; 2019. pp.2\u201367. Available from: https:\/\/training.cochrane.org\/handbook\/current\/chapter-08"},{"key":"e_1_3_5_11_2","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Series C","year":"2008","unstructured":"Series C, , Pt J, , Green S. Cochrane Handbook for Systematic Reviews of Interventions. 1st ed. The Cochrane Collaboration; 2008.","edition":"1"},{"key":"e_1_3_5_12_2","doi-asserted-by":"crossref","unstructured":"Harrer M Cuijpers P Furukawa TA Ebert DD. Doing meta-analysis with R: A Hands-On Guide. In: Chapmann & Hall\/CRC Press eds. Boca Raton FL and London; 2021. Available from: https:\/\/bookdown.org\/MathiasHarrer\/Doing_Meta_Analysis_in_R\/netwma.html","DOI":"10.1201\/9781003107347"},{"key":"e_1_3_5_13_2","unstructured":"Chaimani A Caldwell DM Li T et al. Chapter 11: Undertaking network meta-analyses [Internet]. Training.cochrane.org. Available from: https:\/\/training.cochrane.org\/handbook\/current\/chapter-11"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-015-0060-8"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h4718"},{"key":"e_1_3_5_16_2","unstructured":"NMASTUDIO. NMAstudio: Official Website; 2024. Available from: https:\/\/www.nmastudioapp.com"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.4103\/ayu.AYU_31_18"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8520.190700"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8520.100313"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8520.182761"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.4103\/ayu.AYU_206_20"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.14348"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2008.0573"},{"issue":"4","key":"e_1_3_5_24_2","first-page":"111","article-title":"Role of Punarnava Mandura in iron deficiency Anaemia (Pandu Roga) with special reference to Pradhana Lakshana","volume":"17","author":"Gupta C","year":"2021","unstructured":"Gupta C, , Tiwari S. Role of Punarnava Mandura in iron deficiency Anaemia (Pandu Roga) with special reference to Pradhana Lakshana. J Stress Physiol Biochem, 2021; 17(4):111\u2013118; doi: 10.47223\/IRJAY.2023.6518","journal-title":"J Stress Physiol Biochem"},{"issue":"1","key":"e_1_3_5_25_2","first-page":"4","article-title":"A clinical study to assess the comparative efficacy of Shatavari-Mandur and iron folic acid tablets in the management of Garbhini Pandu","volume":"10","author":"Kanwar R","year":"2016","unstructured":"Kanwar R, , Sharma S, , Dave HH. A clinical study to assess the comparative efficacy of Shatavari-Mandur and iron folic acid tablets in the management of Garbhini Pandu. J Ayurveda, 2016; 10(1):4; doi: 10.17605\/OSF.IO\/5ZEAX","journal-title":"J Ayurveda"},{"issue":"1","key":"e_1_3_5_26_2","first-page":"26","article-title":"Study to evaluate efficacy of Vajravatakmandura in iron deficiency anemia in adolescent girls - A randomized controlled trial","volume":"3","author":"Pareek DR","year":"2018","unstructured":"Pareek DR, , Ojha NK. Study to evaluate efficacy of Vajravatakmandura in iron deficiency anemia in adolescent girls - A randomized controlled trial. J Ayurveda Integr Med, 2018; 3(1):26\u201333; doi: 10.21760\/jaims.v3i01.360","journal-title":"J Ayurveda Integr Med"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8520.123120"},{"issue":"4","key":"e_1_3_5_28_2","first-page":"1061","article-title":"A comparative study of Bibhitakadi Vatak and Dhatri Lauha in the Management of Pandu Roga W.S.R. to iron deficiency Anaemia in children","volume":"4","author":"Seema Singhal H","year":"2022","unstructured":"Seema Singhal H, , Pp V, et al. A comparative study of Bibhitakadi Vatak and Dhatri Lauha in the Management of Pandu Roga W.S.R. to iron deficiency Anaemia in children. Ann Clin Case Stud, 2022; 4(4):1061.","journal-title":"Ann Clin Case Stud"},{"issue":"3","key":"e_1_3_5_29_2","first-page":"32","article-title":"Comparative study of Padmadi Lauham & Iron Folic Acid tablets in the management of Garbhini Pandu","volume":"13","author":"Sharma J","year":"2019","unstructured":"Sharma J, , Sharma S. Comparative study of Padmadi Lauham & Iron Folic Acid tablets in the management of Garbhini Pandu. J Ayurveda, 2019; 13(3):32\u201339.","journal-title":"J Ayurveda"},{"issue":"3","key":"e_1_3_5_30_2","first-page":"31","article-title":"Clinical evaluation of efficacy of \u2018Pippalyadi Yoga\u2019 in the management of Pandu Roga WSR to iron deficiency anemia in children","volume":"12","author":"Sharma N","year":"2018","unstructured":"Sharma N, , Nagar RK, , Khan UA. Clinical evaluation of efficacy of \u2018Pippalyadi Yoga\u2019 in the management of Pandu Roga WSR to iron deficiency anemia in children. J Ayurveda, 2018; 12(3):31.","journal-title":"J Ayurveda"},{"issue":"1","key":"e_1_3_5_31_2","first-page":"84","article-title":"Effect of Dhatriyarishta in the management of Panduroga (iron deficiency anaemia)","volume":"2","author":"Dave U","year":"2014","unstructured":"Dave U, , Thakar A. Effect of Dhatriyarishta in the management of Panduroga (iron deficiency anaemia). Int J Ayurveda Pharma Res, 2014; 2(1):84\u201391.","journal-title":"Int J Ayurveda Pharma Res"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02913329"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.46607\/iamj0408092020"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.47552\/ijam.v14i2.3381"},{"key":"e_1_3_5_35_2","first-page":"363","article-title":"Clinical evaluation of the efficacy of Nisha Lauha and Phal Trikadi Kwath in the management of Pandu WSR to iron deficiency anaemia","volume":"3","author":"Kumawat N","year":"2015","unstructured":"Kumawat N, , Sharma S, , Pandey Y, et al. Clinical evaluation of the efficacy of Nisha Lauha and Phal Trikadi Kwath in the management of Pandu WSR to iron deficiency anaemia. Int Ayurvedic Med J, 2015; 3:363\u2013368.","journal-title":"Int Ayurvedic Med J"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.7897\/2277-4343.1204106"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.34172\/jrhs.8985"},{"key":"e_1_3_5_38_2","article-title":"Efficacy and safety of ayurveda interventions in iron deficiency anemia (ida)\u2013a systematic review","author":"Nair DR","year":"2024","unstructured":"Nair DR, , Pradeepkumar PP, , Remya E, et al. Efficacy and safety of ayurveda interventions in iron deficiency anemia (ida)\u2013a systematic review. Rabinarayanan Acharya\u2019s Lab, 2024; doi: 10.31219\/osf.io\/xmuk2","journal-title":"Rabinarayanan Acharya\u2019s Lab"},{"key":"e_1_3_5_39_2","unstructured":"Ministry of Health and Family Welfare. National Health Policy 2017. New Delhi: Government of India; 2017. Available from Available from: https:\/\/www.nhp.gov.in\/nhpfiles\/national_health_policy_2017.pdf"},{"key":"e_1_3_5_40_2","unstructured":"Ministry of AYUSH. Operational Guidelines for Integration of AYUSH under National Health Mission. New Delhi: Government of India; 2015. Available from: https:\/\/main.ayush.gov.in\/"},{"key":"e_1_3_5_41_2","unstructured":"Ministry of AYUSH. The Ayurvedic Pharmacopoeia of India. Part I Vol IV. New Delhi: Government of India; 2001. Available from: https:\/\/www.ayush.gov.in\/"},{"key":"e_1_3_5_42_2","unstructured":"Ministry of AYUSH. Pharmacovigilance guidelines for Ayurveda Siddha Unani & Homoeopathy Drugs. New Delhi: Government of India; 2018. Available from: https:\/\/www.ayushsuraksha.com\/"},{"issue":"4","key":"e_1_3_5_43_2","first-page":"167","article-title":"Personalized medicine in Ayurveda: Challenges and opportunities","volume":"3","author":"Vaidya ADB","year":"2012","unstructured":"Vaidya ADB. Personalized medicine in Ayurveda: Challenges and opportunities. J Ayurveda Integr Med, 2012; 3(4):167\u2013168.","journal-title":"J Ayurveda Integr Med"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.4103\/0975-9476.154211"},{"issue":"1","key":"e_1_3_5_45_2","first-page":"55","article-title":"Iron preparations in Ayurveda and modern medicine: A review","volume":"11","author":"Gupta PK","year":"2020","unstructured":"Gupta PK, , Bhattacharya S. Iron preparations in Ayurveda and modern medicine: A review. Int J Ayurvedic Med, 2020; 11(1):55\u201360.","journal-title":"Int J Ayurvedic Med"},{"issue":"1","key":"e_1_3_5_46_2","first-page":"49","article-title":"Panduroga Chikitsa in Ayurveda \u2013 A review","volume":"8","author":"Kumar S","year":"2022","unstructured":"Kumar S, , Sharma S. Panduroga Chikitsa in Ayurveda \u2013 A review. J Ayurvedic Herbal Med, 2022; 8(1):49\u201352.","journal-title":"J Ayurvedic Herbal Med"}],"container-title":["Journal of Integrative and Complementary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/27683605251387011","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/27683605251387011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/27683605251387011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:16:40Z","timestamp":1781086600000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/27683605251387011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,15]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,1]]}},"alternative-id":["10.1177\/27683605251387011"],"URL":"https:\/\/doi.org\/10.1177\/27683605251387011","relation":{},"ISSN":["2768-3605","2768-3613"],"issn-type":[{"value":"2768-3605","type":"print"},{"value":"2768-3613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,15]]}}}