{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:06:42Z","timestamp":1784027202552,"version":"3.55.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative and Complementary Medicine"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Xuebijing injection was approved for treating sepsis; however, the efficacy and safety of Xuebijing injection in population with sepsis need further evaluation. We aimed to evaluate the safety and efficacy of Xuebijing injection on sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We searched for potential randomized controlled trials about Xuebijing injection and sepsis from six public databases. Primary outcomes included the 28-day mortality and mortality during treatment. Our secondary outcomes were body temperature, APACHE \u2161 score, and adverse events or reactions. All data were synthesized by the meta package.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 3007 patients (1551 patients receiving the conventional treatment combined with Xuebijing injection and 1456 patients receiving the conventional treatment only) were included. We found Xuebijing injection reduced the 28-day mortality (risk ratio = 0.69 [0.60\u20130.78],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001), mortality during treatment (risk ratio = 0.74 [0.62\u20130.88],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.0009), APACHE II score (mean difference = 3.91 [2.45\u20135.38],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001), and body temperature (mean difference = 0.43 [0.31\u20130.55],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.0001) without obvious adverse events (risk ratio = 0.91 [0.77\u20131.07],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.2405).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Xuebijing injection is effective and safe for treating sepsis. Additional methodologically sound trials with long-term mortality as an outcome measure could provide further insights into whether Xuebijing injection offers an enhanced therapeutic effect for sepsis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/27683605251415490","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T12:27:06Z","timestamp":1770208026000},"page":"611-618","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Xuebijing Injection, an Herbal-Based Injection, in Patients with Sepsis: Evidence from Randomized Controlled Trials of 3007 Subjects"],"prefix":"10.1177","volume":"32","author":[{"given":"Gang","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Rehabilitation, Chongqing Mental Health Center, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Key Laboratory for the Prevention and Treatment of Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chongqing Hospital of TCM, Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Massage, The Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Key Laboratory for the Prevention and Treatment of Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.0788"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000005337"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14199"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-017-0622-8"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116521"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.explore.2022.10.018"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110280"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113301"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6621368"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2989846"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000003842"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.104293"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.05.043"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.0780"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.Ccm.0000050454.01978.3b"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4683-6"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31827e83af"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-141-10-200411160-00009"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-073725"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.707394"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/00368504211012160"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental-2019-300117"},{"key":"e_1_3_3_25_2","unstructured":"Wang Q. The protective effect of Xuebijing injection on organ function and its impact on IL-6 and IL-10 in patients with sepsis (stasis toxin internal obstruction syndrome). Fujian University of Traditional Chinese Medicine: 2008."},{"issue":"24","key":"e_1_3_3_26_2","first-page":"4272","article-title":"The effect of Xuebijing injection on coagulation function in patients with severe post-traumatic sepsis","volume":"24","author":"Zhang H-W","year":"2008","unstructured":"Zhang H-W, , Wei Y-Y, , Zhang X-P, et al. The effect of Xuebijing injection on coagulation function in patients with severe post-traumatic sepsis. 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