{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:47:15Z","timestamp":1792759635246,"version":"4.5.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative and Complementary Medicine"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"\n Aim:<\/jats:title>\n Calcaneal spur is a common cause of chronic heel pain and functional disability. This study aimed to evaluate the efficacy and safety of individualized homeopathic (IH) medicines compared to placebo (PL) in managing this condition.<\/jats:p>\n <\/jats:sec>\n \n Method:<\/jats:title>\n \n In this double-blind, randomized, PL-controlled trial, 128 participants with chronic heel pain from calcaneal spur were randomly assigned to receive either IH (\n n<\/jats:italic>\n = 64) or an identical PL (\n n<\/jats:italic>\n = 64) for 6 months. Both groups received standard advice on general management (such as foot exercises and contrast baths). The primary outcome was the change in pain intensity from baseline measured on a 100-mm visual analog scale (VAS). The secondary outcome was the change in lower extremity function measured by the Lower Extremity Functional Scale (LEFS). Outcomes were assessed at baseline, 3 months, and 6 months. Analysis was done using an intention-to-treat approach with a mixed-effects model for repeated measures.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The analysis revealed a statistically significant group \u00d7 time interaction for VAS pain scores (\n F<\/jats:italic>\n -value = 35.12,\n p<\/jats:italic>\n < 0.001). At 6 months, the IH group showed a significantly greater mean reduction in pain compared to the PL group (mean difference: \u221233.28; 95% confidence interval [CI]: \u221244.3 to \u221222.2;\n p<\/jats:italic>\n < 0.001). Similarly, a significant group \u00d7 time interaction was observed for LEFS scores (\n F<\/jats:italic>\n -value = 33.87,\n p<\/jats:italic>\n < 0.001). At 6 months, the IH group had a greater improvement in function (mean difference: 13.78; 95% CI: 9.1\u201318.4;\n p<\/jats:italic>\n < 0.001). Both results were clinically significant. No serious adverse events were reported.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Individualized homeopathy resulted in statistically and clinically significant improvements in pain and function for patients with calcaneal spur compared to PL. These findings suggest that homeopathy may be a viable treatment option for this condition.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/27683605261417653","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T13:13:54Z","timestamp":1770210834000},"page":"619-625","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Individualized Homeopathic Medicines in Managing Pain of Calcaneal Spur: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial"],"prefix":"10.1177","volume":"32","author":[{"given":"Pratima","family":"Pramanik","sequence":"first","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Metropolitan Homoeopathic Medical College and Hospital, Kolkata, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena Prakash","family":"Bharti","sequence":"additional","affiliation":[{"name":"Department of Practice of Medicine, D.N.De Homoeopathic Medical College and Hospital, Kolkata, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himangsu","family":"Hait","sequence":"additional","affiliation":[{"name":"Department of Practice of Medicine, The Calcutta Homoeopathic Medical College and Hospital, Kolkata, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Case taking & Repertory, The Calcutta Homoeopathic Medical College and Hospital, Kolkata, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Dutta","sequence":"additional","affiliation":[{"name":"International Cooperation Section, Ministry of Ayush (Government of India), New Delhi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key266"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12607"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/2229-516X.140709"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009348.pub2"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1775995"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-57041"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-017-0445-3"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7168.200844"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-0785(05)80174-7"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1731383"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"e_1_3_5_13_2","unstructured":"Anonymous. Common Terminology Criteria for Adverse Events (CTCAE) | Protocol Development. CTEP. n.d. Available from: https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/ctc.htm [Last accessed: December7 2023]."},{"key":"e_1_3_5_14_2","unstructured":"Anonymous. English. MedDRA. n.d. Available from: https:\/\/www.meddra.org\/how-to-use\/support-documentation\/english [Last accessed: December7 2023]."},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1757-1146-3-7"},{"key":"e_1_3_5_16_2","first-page":"81","article-title":"A preliminary investigation into the effectiveness of the homeopathic remedy, Ruta graveolens, in the treatment of pain in plantar fasciitis","volume":"3","author":"Clark J","unstructured":"Clark J, , Percivall A. A preliminary investigation into the effectiveness of the homeopathic remedy, Ruta graveolens, in the treatment of pain in plantar fasciitis. Br J Podiatr, n.d; 3:81\u201385.","journal-title":"Br J Podiatr"}],"container-title":["Journal of Integrative and Complementary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/27683605261417653","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/27683605261417653","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/27683605261417653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T10:46:59Z","timestamp":1784026019000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/27683605261417653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,1]]}},"alternative-id":["10.1177\/27683605261417653"],"URL":"https:\/\/doi.org\/10.1177\/27683605261417653","relation":{},"ISSN":["2768-3605","2768-3613"],"issn-type":[{"value":"2768-3605","type":"print"},{"value":"2768-3613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,4]]}}}