{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T23:56:26Z","timestamp":1793058986346,"version":"4.5.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative and Complementary Medicine"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>\n                      To evaluate whether\n                      <jats:italic toggle=\"yes\">Matricaria chamomilla<\/jats:italic>\n                      (Chamomile) supplementation enhances quality of life (QOL) specifically in vasomotor, psychological, physical, and sexual domains among postmenopausal women in Iran, where research on natural remedies for menopause management is limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this triple-blind randomized controlled trial, 80 postmenopausal women aged 47\u201362 years were randomly assigned to receive either 400 mg Chamomile capsules daily (standardized to 1.2% apigenin) or placebo for 12 weeks. Randomization was performed using permuted blocks, and the study was triple-blinded (participants, researchers, and data analysts). QOL was assessed using the Menopause-Specific Quality of Life Questionnaire at baseline and 12 weeks. Data were analyzed using analysis of covariance with baseline score adjustments and an intention-to-treat approach for missing data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Chamomile significantly reduced vasomotor symptoms compared to placebo (mean difference = \u22120.82, 95% confidence interval: \u22121.25 to \u22120.39,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2264 0.001). No significant improvements were observed in psychological, physical, sexual, or overall QOL scores. Mild side effects (mouth sores, skin spots) caused the withdrawal of two participants from the Chamomile group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Chamomile supplementation demonstrates efficacy in alleviating vasomotor symptoms in postmenopausal women, likely due to its phytoestrogenic properties, but has a limited impact on other QOL domains.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/27683605261426288","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T12:19:08Z","timestamp":1772281148000},"page":"744-751","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of\n                    <i>Matricaria chamomilla<\/i>\n                    on the Quality of Life Among Women with Menopausal Symptoms: A Triple-Blind Randomized Controlled Trial"],"prefix":"10.1177","volume":"32","author":[{"given":"Farideh","family":"Mohsenzadeh-Ledari","sequence":"first","affiliation":[{"name":"Infertility and Health Reproductive Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6906-1440","authenticated-orcid":false,"given":"Mouloud Agajani","family":"Delavar","sequence":"additional","affiliation":[{"name":"Infertility and Health Reproductive Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Akbar","family":"Moghadamnia","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Biology Research Center, Health Research Institute, Babol, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Bekhradi","sequence":"additional","affiliation":[{"name":"Barij Medical Plants Research Center, Kashan, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorya","family":"Khafri","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Babol, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Behmanesh","sequence":"additional","affiliation":[{"name":"Infertility and Health Reproductive Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahla","family":"Yazdani","sequence":"additional","affiliation":[{"name":"Infertility and Health Reproductive Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-020-00960-4"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/13697137.2018.1506435"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.21608\/msnj.2018.187730"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.180"},{"issue":"1","key":"e_1_3_2_6_2","first-page":"492","article-title":"Healthy life style behaviors and quality of life at menopause","volume":"12","author":"Ozcan H","year":"2019","unstructured":"Ozcan H. 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Chamomile: A herbal medicine of the past with a bright future. Mol Med Rep, 2010; 3(6):895\u2013901.","journal-title":"Mol Med Rep"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-11-78"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123911"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174175"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmm048"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000002496"},{"issue":"1","key":"e_1_3_2_24_2","first-page":"81","article-title":"Quality of life and related factors in menopausal women in Kashan city","volume":"12","author":"Abedzadeh M","year":"2009","unstructured":"Abedzadeh M, , Taebi M, , Saberi F, , Sadat Z. Quality of life and related factors in menopausal women in Kashan city. 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