{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T06:12:17Z","timestamp":1788502337591,"version":"build-2803163510"},"reference-count":44,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Chemiloids Life Sciences Pvt. Ltd, Aswaraopeta, Khammam, Telangana, India.","award":["CL 1601921"],"award-info":[{"award-number":["CL 1601921"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative and Complementary Medicine"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      Distal radius fracture (DRF) is the most frequent injury to the upper limb. Complications include nonunion, wrist stiffness and instability, local discomfort, and tendon irritation. The purpose of the current open-label clinical study was to evaluate the safety, efficacy, and tolerability of CL16019, an herbal formulation of\n                      <jats:italic toggle=\"yes\">Cissus quadrangularis<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Boswellia serrata<\/jats:italic>\n                      extract, in accelerating fracture healing in volunteers with DRFs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Fifty participants (both male and female; age: 30\u201350 years) with type I, IIA, or IIB DRFs (as per Lidstrom classification) were equally randomized and treated with standard treatment (ST) or ST + CL16019 for 60 days. The primary efficacy outcome was the radiographical bone fracture healing rate as scored by the Radius Union Scoring System (RUSS). Pain, swelling, and tenderness were among the clinical characteristics evaluated using the visual analog scale (VAS). Wrist function improvements were assessed using the Patient-Rated Wrist Evaluation Questionnaire (PRWEQ). The intergroup and intragroup results were analyzed using a paired\n                      <jats:italic toggle=\"yes\">t-<\/jats:italic>\n                      test and an analysis of covariance model, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The RUSS scores for the ST and ST + CL16019 groups at the end of the trial were 5.54 \u00b1 1.77 and 7.96 \u00b1 0.20, respectively, with a\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      -value &lt;0.0001. In addition, the CL16019 volunteers showed substantial (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05) declines in their VAS and PRWEQ scores. The ST + CL16019 group demonstrated higher Physician Global Assessment and Subject Global Assessment scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Supplementation of CL16019 along with standard therapy was found to enhance the bone fracture healing rate, possibly by accelerating the callus formation rate and enhancing cortical bridging. These findings imply that CL16019 might be a good adjunctive in addition to ST for the faster healing of DRFs. The trial was registered with the Clinical Trial Registry of India (CTRI) with the registration number CTRI\/2021\/12\/039006, on December 29, 2021.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/27683605261435781","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T03:57:20Z","timestamp":1774670240000},"page":"808-820","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["CL16019, A Combination of\n                    <i>Cissus quadrangularis<\/i>\n                    and\n                    <i>Boswellia serrata<\/i>\n                    Extracts Promotes the Healing of Distal Radius Fractures: A Multicentric, Randomized, Open-Label Study"],"prefix":"10.1177","volume":"32","author":[{"given":"Anjaneya Venkata Vara Prasad","family":"Mungara","sequence":"first","affiliation":[{"name":"Orthopedic Department &amp; Division, Vijaya Super Speciality Hospital, Nellore, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawazish Rabbani","family":"Shaik","sequence":"additional","affiliation":[{"name":"Orthopedic Department &amp; Division, NUHA Hospitals, Guntur, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandra Kiran","family":"M.","sequence":"additional","affiliation":[{"name":"Orthopedic Department &amp; Division, Pranaam Hospital, Hyderabad, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun P.","family":"Sureja","sequence":"additional","affiliation":[{"name":"Department of Scientific and Medical Affairs, Sundyota Numandis Probioceuticals Pvt. 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