{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T18:19:55Z","timestamp":1783621195791,"version":"3.55.0"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative and Complementary Medicine"],"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Breast biopsies often cause anxiety and pain that influence patients\u2019 experience and procedure outcomes. Music interventions offer a practical alternative to pharmacological methods for reducing these effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a PRISMA-compliant systematic review and meta-analysis to evaluate the efficacy of music during breast biopsies. We searched PubMed, Cochrane CENTRAL Library, EMBASE, and ClinicalTrials.gov up to May 2025. We included randomized controlled trials (RCTs) comparing music interventions with routine care without music intervention. The primary outcomes were anxiety and pain scores; secondary outcomes assessed changes in these scores before and after the procedure. We calculated standardized mean differences (SMDs) with 95% confidence intervals (CIs) using a random-effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Seven RCTs with 606 participants met the inclusion criteria. The mean age of participants was 50.8 years. Anxiety scores were significantly lower in the music group compared with controls (SMD = \u20130.22, 95% CI: \u20130.38 to \u20130.06,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05,\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0%). Anxiety reduction from pre- to postprocedure was also greater with music (SMD = 0.25, 95% CI: 0.07\u20130.44,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05,\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 0%). However, pain scores did not differ significantly (SMD = \u20130.33, 95% CI: \u20130.83 to 0.17,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &gt; 0.05,\n                      <jats:italic toggle=\"yes\">I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 82%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Music interventions were associated with a small but statistically significant reduction in anxiety during breast biopsy procedures, but no significant reduction in pain. These findings support music as a safe, nonpharmacological option to improve patient experience, particularly with respect to procedural anxiety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/27683605261461167","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T05:15:53Z","timestamp":1783401353000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Music Intervention for Anxiety and Pain During Breast Biopsy Procedures: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.1177","author":[{"given":"Yao","family":"Chen","sequence":"first","affiliation":[{"name":"Changchun Guanghua University, Changchun, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafiza","family":"Qurat Ul Ain","sequence":"additional","affiliation":[{"name":"Department of Medicine, CMH Multan, Punjab, Pakistan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inshal","family":"Jawed","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1248-0785","authenticated-orcid":false,"given":"Abu Huraira","family":"Bin Gulzar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Services Institute of Medical Sciences, Lahore, Pakistan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Umair","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Yokolo","sequence":"additional","affiliation":[{"name":"Department of Research, Medical Research Circle, Goma, DR Congo."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danaish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Karachi Medical and Dental College, Karachi, Pakistan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016161174"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/17455057241276232"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.177.5.1771167"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn010"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12824"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.Ane.0000068822.10113.9e"},{"key":"e_1_3_2_8_1","volume-title":"Crossing the quality chasm: A new health system for the 21st century","author":"Institute of Medicine Committee on Quality of Health Care in A","year":"2001","unstructured":"7.Institute of Medicine Committee on Quality of Health Care in A. 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