{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:44:52Z","timestamp":1782755092066,"version":"3.54.5"},"reference-count":60,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative and Complementary Medicine"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Ayurvedic dravya-based herbal products are increasingly studied for cognition, stress, sleep, and psychiatric symptoms, but synthesis is complicated by heterogeneous preparations, incomplete reporting of Rasapanchaka-relevant attributes, and ambiguous common-name labels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To synthesize controlled human evidence on dravya-based herbal products for (A) cognition, (B) stress, sleep, and related well-being outcomes, and (C) psychiatric symptoms\/disorders using a node-resolved framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a PRISMA 2020-reported, node-resolved systematic review of controlled human studies evaluating a defined dravya node and at least one standardized mental-health instrument or cognitive test. PubMed\/MEDLINE, the AYUSH Research Portal, and DHARA were searched from database inception to 4 January 2026; the evidence base was frozen on January 30, 2026, after deduplication, full-text retrieval, and manual reference-list screening. Interventions were mapped to node identifiers using botanical identity, part\/material, and preparation; identity-uncertain labels were retained as separate strata.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Forty-nine controlled reports spanning 20 nodes were included. Evidence volume was concentrated in\n                      <jats:italic toggle=\"yes\">Bacopa monnieri<\/jats:italic>\n                      (Brahmi) for cognition and\n                      <jats:italic toggle=\"yes\">Withania somnifera<\/jats:italic>\n                      (Ashwagandha) for stress and sleep outcomes. Meta-analysis was feasible for three primary strata:\n                      <jats:italic toggle=\"yes\">W. somnifera<\/jats:italic>\n                      (Ashwagandha) versus placebo on perceived stress and sleep quality, and curcumin versus placebo on depression severity. Reported adverse events were usually mild but inconsistently captured.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Selected dravya nodes show potentially beneficial signals, but confidence in effect magnitude remains limited by heterogeneity, small-study effects, and reporting quality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/27683605261461431","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T10:55:35Z","timestamp":1782471335000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ayurvedic Dravya-Based Herbal Products for Cognition, Stress, Sleep, and Psychiatric Symptoms: A Node-Resolved Systematic Review and Meta-Analysis"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-426X","authenticated-orcid":false,"given":"Bernhard T.","family":"Baune","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of M\u00fcnster, M\u00fcnster, Germany."},{"name":"Maganbhai Adenwala Mahagujarat University, Nadiad, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansi M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Maganbhai Adenwala Mahagujarat University, Nadiad, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish V.","family":"Patel","sequence":"additional","affiliation":[{"name":"Maganbhai Adenwala Mahagujarat University, Nadiad, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivenarain N.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Maganbhai Adenwala Mahagujarat University, Nadiad, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(21)00395-3"},{"key":"e_1_3_3_3_2","unstructured":"World Health Organization. World mental health report: Transforming mental health for all [Internet]. Geneva: World Health Organization; 2022. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789240049338 [Last accessed: Jan4 2026]."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.2051-5545.2010.tb00305.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-7847.99949"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_3_3_9_2","unstructured":"Higgins JPT Thomas J Chandler J Cumpston M Li T Page MJ et al. editors. Cochrane Handbook for systematic reviews of interventions version 6.5. Cochrane; 2024. Available from: https:\/\/www.cochrane.org\/handbook [Last accessed: Jan4 2026]."},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100815"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00419-5"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5545.31555"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2008.0018"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2537"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2009.0342"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/606424"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.4864"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4103\/aian.AIAN_610_19"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-025-01492-1"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200012000-00015"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.11.038"},{"issue":"1","key":"e_1_3_3_23_2","first-page":"8","article-title":"A clinical study on the management of generalized anxiety disorder with Centella asiatica","volume":"12","author":"Jana U","year":"2010","unstructured":"Jana U, , Sur TK, , Maity LN, et al. A clinical study on the management of generalized anxiety disorder with Centella asiatica. Nepal Med Coll J, 2010; 12(1):8\u201311.","journal-title":"Nepal Med Coll J"},{"issue":"3","key":"e_1_3_3_24_2","first-page":"42","article-title":"Effect of Sankhapushpi (Clitoria ternatea Linn.) choorna in the working memory of children","volume":"7","author":"Reshma RG","year":"2019","unstructured":"Reshma RG, , Anirudhan R. Effect of Sankhapushpi (Clitoria ternatea Linn.) choorna in the working memory of children. Int J Ayurveda Pharma Res, 2019; 7(3):42\u201348.","journal-title":"Int J Ayurveda Pharma Res"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-8520.141916"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113276"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7176.106022"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.5797"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.6466"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8254344"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000035521"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/02698811231200023"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu16091293"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017186"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.03.012"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e36885"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-025-03327-z"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/894509"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.965130"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1695341"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu16121867"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S544267"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2018.01.001"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-4-12"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1647"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.11.004"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1515\/jcim-2015-0043"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.606124"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e31828ef969"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.06.001"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2014.11.015"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000352"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbii.2023.100012"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2025.104611"},{"issue":"4","key":"e_1_3_3_55_2","first-page":"668","article-title":"A clinical study on the management of generalized anxiety disorder with Vaca (Acorus calamus)","volume":"10","author":"Bhattacharyya D","year":"2011","unstructured":"Bhattacharyya D, , Sur TK, , Lyle N, et al. A clinical study on the management of generalized anxiety disorder with Vaca (Acorus calamus). Indian J Tradit Knowl, 2011; 10(4):668\u2013671.","journal-title":"Indian J Tradit Knowl"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.47552\/ijam.v11i3.1627"},{"issue":"4","key":"e_1_3_3_57_2","first-page":"668","article-title":"A clinical study on the management of anxiety neurosis with Sankhaholi","volume":"6","author":"Shamsi Y","year":"2007","unstructured":"Shamsi Y, , Ahmad J, , Khan AA. A clinical study on the management of anxiety neurosis with Sankhaholi. Indian J Tradit Knowl, 2007; 6(4):668\u2013677.","journal-title":"Indian J Tradit Knowl"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2006.11.010"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.104865"},{"key":"e_1_3_3_60_2","volume-title":"Bhavamishra. Bhavaprakasha Nighantu","author":"Chunekar KC","year":"2010","unstructured":"Bhavamishra. Bhavaprakasha Nighantu. Chunekar KC, , Pandey GS., editors. Varanasi: Chaukhambha Bharati Academy; 2010."},{"key":"e_1_3_3_61_2","volume-title":"The Ayurvedic Pharmacopoeia of India. Part I, Vols 1\u20136","author":"Government of India, Ministry of Health and Family Welfare, Department of AYUSH","year":"2001","unstructured":"Government of India, Ministry of Health and Family Welfare, Department of AYUSH. The Ayurvedic Pharmacopoeia of India. Part I, Vols 1\u20136. New Delhi: The Controller of Publications; 2001\u20132011."}],"container-title":["Journal of Integrative and Complementary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/27683605261461431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/27683605261461431","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/27683605261461431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:59:31Z","timestamp":1782752371000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/27683605261461431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":60,"alternative-id":["10.1177\/27683605261461431"],"URL":"https:\/\/doi.org\/10.1177\/27683605261461431","relation":{},"ISSN":["2768-3605","2768-3613"],"issn-type":[{"value":"2768-3605","type":"print"},{"value":"2768-3613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,26]]},"article-number":"27683605261461431"}}