{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T17:46:28Z","timestamp":1791740788555,"version":"4.3.4"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Maragheh University of Medical Sciences","id":[{"id":"https:\/\/ror.org\/03xjqy265","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative and Complementary Medicine"],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Natural products, including medicinal plants, have been explored for obesity management.\n                      <jats:italic toggle=\"yes\">Coleus forskohlii<\/jats:italic>\n                      contains the bioactive compound forskolin, which may influence body composition and weight regulation. This systematic review assessed the effectiveness and safety of\n                      <jats:italic toggle=\"yes\">C. forskohlii<\/jats:italic>\n                      extract as an anti-obesity agent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>PubMed, Scopus, Web of Science, Cochrane Central Register of Controlled Trials, and Google Scholar were systematically searched from January 1990 to May 2023. Study selection and data extraction were performed independently by two reviewers. Risk of bias was evaluated using the Cochrane Risk of Bias 1 tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Four randomized controlled trials met inclusion criteria. Evidence suggests that\n                      <jats:italic toggle=\"yes\">C. forskohlii<\/jats:italic>\n                      extract may reduce fat mass and body fat percentage; however, findings regarding weight loss and overall body composition have been inconsistent. Adverse effects were generally mild and infrequent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Current evidence suggests that\n                      <jats:italic toggle=\"yes\">C. forskohlii<\/jats:italic>\n                      extract may serve as a complementary therapy for obesity. High-quality, long-term, double-blind, randomized, placebo-controlled trials are required to confirm its efficacy and safety.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/27683605261492576","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:06:16Z","timestamp":1791453976000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effectiveness and Safety of\n                    <i>Coleus forskohlii<\/i>\n                    Extract as an Anti-Obesity Agent: A Systematic Review"],"prefix":"10.1177","author":[{"given":"Elhameh","family":"Nikkhah","sequence":"first","affiliation":[{"name":"Medicinal Plants Research Center, Maragheh University of Medical Sciences, Maragheh, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Ostadrahimi","sequence":"additional","affiliation":[{"name":"Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Medicinal Plants Research Center, Maragheh University of Medical Sciences, Maragheh, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9353-8066","authenticated-orcid":false,"given":"Nima","family":"Radkhah","sequence":"additional","affiliation":[{"name":"Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soghra","family":"Aliasgharzadeh","sequence":"additional","affiliation":[{"name":"Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Khorrami","sequence":"additional","affiliation":[{"name":"Medicinal Plants Research Center, Maragheh University of Medical Sciences, Maragheh, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Pourmoradian","sequence":"additional","affiliation":[{"name":"Department of Community Nutrition, Nutrition Research Center, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(14)60460-8"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.171016"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.613828"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(11)60105-0"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021423"},{"key":"e_1_3_4_7_1","first-page":"s176","article-title":"Obesity: Definition, comorbidities, causes, and burden","volume":"22","author":"Apovian CM","year":"2016","unstructured":"6.Apovian CM. 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