{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:38:04Z","timestamp":1792687084815,"version":"4.5.0"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Integrative and Complementary Medicine"],"abstract":"\n Objective:<\/jats:title>\n This is a retrospective cohort study assessing the association between the use of Traditional Chinese Medicine (TCM) and the risk of lower-limb amputation, cardiovascular (CV) mortality, and all-cause mortality among people with peripheral arterial occlusive disease (PAOD).<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n The study utilized data from the National Health Insurance Research Database of the Ministry of Health and Welfare of Taiwan. A 1:1 propensity score matching ratio based on gender, age (5-year interval), comorbidities, medications, and year of index date.<\/jats:p>\n The risk of outcomes among PAOD patients with and without TCM use was estimated by a Cox proportional hazards model.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The study findings showed that TCM treatment was associated with a significant decreased risk of lower-limb loss (adjusted hazard ratio [aHR] = 0.55, 95% confidence interval [CI] = 0.50\u20130.61), CV death (aHR = 0.33, 95% CI = 0.31\u20130.34), and all-cause mortality (aHR = 0.34, 95% CI = 0.34\u20130.35) among people with PAOD, especially for CV death and all-cause death.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n We found that patients with PAOD treated with TCM have a decreased risk of endpoints, especially for CV death and all-cause death.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/27683605261499015","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T06:33:02Z","timestamp":1792391582000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of Traditional Chinese Medicine Therapy with Risks of Lower-Limb Amputation, Cardiovascular Mortality and All-Cause Mortality in Patients with Peripheral Arterial Occlusive Disease\u2014A Retrospective Cohort Study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2478-923X","authenticated-orcid":false,"given":"Wei-Syun","family":"Hu","sequence":"first","affiliation":[{"name":"School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan."},{"name":"Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital, Taichung, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61576-7"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61249-0"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0133"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.078"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319710382771"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2018.01.019"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.01.067"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114604"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.613922"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-021-2866-z"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.03.005"},{"key":"e_1_3_3_13_1","first-page":"1011","article-title":"Explration of the essence of \u201cendogenous turbidity\u201d in Chinese medicine","volume":"35","author":"Fan XG","year":"2015","unstructured":"12.Fan XG, , Tang N, , Ji YX, et al. 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