{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:32:16Z","timestamp":1777883536518,"version":"3.51.4"},"reference-count":8,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA052937"],"award-info":[{"award-number":["R01DA052937"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA056045"],"award-info":[{"award-number":["R01DA056045"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32DA007209"],"award-info":[{"award-number":["T32DA007209"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Substance Use &amp; Addiction Journal"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The Divided or Single Exposure (DOSE) trial is a double-blind, placebo-controlled examination of once versus split dosing of methadone for comorbid pain and opioid use disorder (OUD) among persons receiving methadone for OUD treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This multisite trial consists of a 12-week active intervention phase and 6-month follow-up period. Persons receiving methadone who endorse clinically-significant chronic pain are randomized into once-daily dosing or split dosing that is managed remotely via an electronic pillbox. Clinical pain is assessed weekly and using ecological momentary assessments. Experimentally-evoked pain is assessed using a quantitative sensory testing battery. Additional outcomes related to OUD, including withdrawal and craving, are also collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The study hypothesizes that persons assigned to the split dosing condition will report lower pain and opioid withdrawal relative to persons assigned to the traditional once-daily dosing strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Split dosing is a relatively common technique in OUD treatments; therefore, if data support this hypothesis, there is high potential for implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/29767342241239167","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T01:35:15Z","timestamp":1711416915000},"page":"197-200","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The IMPOWR Network Divided or Single Exposure Study (DOSE) Protocol: A Randomized Controlled Comparison of Once Versus Split Dosing of Methadone for the Treatment of Comorbid Chronic Pain and Opioid Use Disorder"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2000-2201","authenticated-orcid":false,"given":"Greer","family":"McKendrick","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Will","family":"Davis","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sklar","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Brown","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Pattillo","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick H.","family":"Finan","sequence":"additional","affiliation":[{"name":"University of Virginia School of Medicine, Charlottesville, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Antoine","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6692-0111","authenticated-orcid":false,"given":"Vickie","family":"Walters","sequence":"additional","affiliation":[{"name":"Institute for Behavior Resources, Inc., REACH Health Services, Baltimore MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly E.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, Baltimore MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"Substance Abuse and Mental health Services Administration. Key Substance Use and Mental Health Indicators in the United States: Results From the 2018 National Survey on Drug Use and Health. Center for Behavioral Health Statistics and Quality Substance Abuse and Mental Health Services Administration; 2019. HHS publication no. PEP19-5068 NSDUH series H-54. 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