{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:32:38Z","timestamp":1777883558019,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T00:00:00Z","timestamp":1722124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DA055933"],"award-info":[{"award-number":["K23DA055933"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24DA046309"],"award-info":[{"award-number":["K24DA046309"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24DA057873"],"award-info":[{"award-number":["K24DA057873"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AI124414"],"award-info":[{"award-number":["P30AI124414"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DA054885"],"award-info":[{"award-number":["R01DA054885"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH120601"],"award-info":[{"award-number":["R01MH120601"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH126821"],"award-info":[{"award-number":["R01MH126821"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH128878"],"award-info":[{"award-number":["R01MH128878"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21MH121920"],"award-info":[{"award-number":["R21MH121920"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21MH126501"],"award-info":[{"award-number":["R21MH126501"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RM1DA055437"],"award-info":[{"award-number":["RM1DA055437"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Substance Use &amp; Addiction Journal"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Buprenorphine is an effective medication for both opioid use disorder (OUD) and chronic pain (CP), but transitioning from full opioid agonists to buprenorphine, a partial opioid agonist, can be challenging. Preliminary studies suggest that low-dose buprenorphine initiation can overcome some challenges in starting treatment, but no randomized controlled trials have compared low-dose and standard buprenorphine initiation approaches regarding effectiveness and safety or examined implementation in hospital settings. In a pragmatic open-label hybrid type I effectiveness-implementation trial based in a single urban health system, 270 hospitalized patients with (a) CP and (b) OUD or opioid misuse are being randomized to buprenorphine treatment initiation using 5-day low-dose or standard initiation protocols. Outcomes include buprenorphine treatment uptake (primary), defined as receiving buprenorphine treatment 7\u2009days after enrollment, and other OUD and pain outcomes at 1-, 3-, and 6-month follow-up (secondary). Data collection will also include safety measures, implementation of low-dose initiation protocols, patient acceptability, and cost-effectiveness. Comparing strategies in a randomized clinical trial will provide the most definitive data to date regarding the effectiveness and safety of low-dose buprenorphine initiation. The study will also provide important data on treating CP at a time that clinical guidelines are evolving to center buprenorphine as a preferred opioid for CP.<\/jats:p>","DOI":"10.1177\/29767342241263221","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T05:13:49Z","timestamp":1743743629000},"page":"184-191","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Low-Dose Buprenorphine Initiation for Hospitalized Patients With Chronic Pain and Opioid Use Disorder or Opioid Misuse: Protocol for an Open-Label, Parallel-Group, Effectiveness-Implementation Randomized Controlled Trial"],"prefix":"10.1177","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4282-6869","authenticated-orcid":false,"given":"Benjamin T.","family":"Hayes","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Sanchez Fat","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine","family":"Torres-Lockhart","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Khalid","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruka","family":"Minami","sequence":"additional","affiliation":[{"name":"Psychology Department, Fordham University, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Ghiroli","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Beth","family":"Hribar","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Pacifico","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhua","family":"Bao","sequence":"additional","affiliation":[{"name":"Population Health Sciences, Weill Cornell Medicine, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caryn R. R.","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Department of Psychology and Behavioral Sciences, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilma","family":"Gabbay","sequence":"additional","affiliation":[{"name":"Department of Psychology and Behavioral Sciences, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Starrels","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6904-4795","authenticated-orcid":false,"given":"Aaron D.","family":"Fox","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,7,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/29767342241236592"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002207.pub4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000002718"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10345"},{"key":"e_1_3_3_6_2","article-title":"Conversion of chronic pain patients from full-opioid agonists to sublingual buprenorphine","volume":"15","author":"Daitch J","year":"2012","unstructured":"Daitch J, Frey ME, Silver D, Mitnick C, Daitch D, Pergolizzi JJr. Conversion of chronic pain patients from full-opioid agonists to sublingual buprenorphine. Pain Physician. 2012;15(3 suppl):ES59-ES66.","journal-title":"Pain Physician"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-023-00443-5"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/10550887.2012.694598"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j1550"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-019-00143-6"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12196"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000000170"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2011\/14\/145"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.107675"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.172"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.27488"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/adm.0000000000001202"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2007.04.006"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0376-8716(03)00056-5"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2018.09.001"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnw078"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2012.0137"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2010.05.014"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-008-0866-8"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/adm.0000000000000922"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13722-021-00244-8"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/adm.0000000000000945"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.13135"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2020.106740"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/adm.0000000000000947"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/adm.0000000000000864"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.josat.2023.209261"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2018.06.008"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12789"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.06.039"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.2556"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2017.05.007"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-009-0981-1"},{"key":"e_1_3_3_39_2","unstructured":"Hughes A Williams MR Lipari R Bose J Copello E Kroutil L. Prescription drug use and misuse in the United States: results from the 2015 National Survey on Drug Use and Health. NSDUH Data Review. 2016. Accessed June 27 2023. https:\/\/www.samhsa.gov\/data\/sites\/default\/files\/NSDUH-FFR2-2015\/NSDUH-FFR2-2015.htm"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1097\/adm.0000000000000745"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/adm.0000000000000633"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2003.10400007"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/0740-5472(92)90062-s"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1080\/08897077.2011.638734"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphys.2015.07.001"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1177\/0272989x18776637"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.12195"},{"key":"e_1_3_3_49_2","unstructured":"Mathew N Azar P. Comparing rapid micro-induction and standard induction of buprenorphine\/naloxone for treatment of opioid use disorder. ClinicalTrials.gov identifier NCT04234191. 2022. Accessed April 29 2024. https:\/\/clinicaltrials.gov\/study\/NCT04234191?cond=opioid%20use%20disorder&intr=microdosing%20buprenorphine&rank=5#collaborators-and-investigators"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.7326\/m22-2917"}],"container-title":["Substance Use &amp; Addiction Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/29767342241263221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/29767342241263221","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/29767342241263221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:50:03Z","timestamp":1777600203000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/29767342241263221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,28]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1177\/29767342241263221"],"URL":"https:\/\/doi.org\/10.1177\/29767342241263221","relation":{},"ISSN":["2976-7342","2976-7350"],"issn-type":[{"value":"2976-7342","type":"print"},{"value":"2976-7350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,28]]}}}