{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:10:35Z","timestamp":1792185035071,"version":"4.4.0"},"reference-count":11,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Substance Use &amp; Addiction Journal"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>Transitions from high-dose methadone to buprenorphine remain challenging, and the evidence base for high-dose buprenorphine initiation (HDBI) strategies in this context is limited. We reviewed the published literature on HDBI with a particular focus on their application for patients maintained on methadone and identified no prior reports of successful transition from methadone doses as high as 180\u2009mg. We then describe a hospitalized patient who underwent a safe and effective transition from 180\u2009mg of methadone to buprenorphine through a high-dose initiation protocol with support of adjunctive medications. The patient stabilized within 1\u2009week on 32\u2009mg of buprenorphine daily and later on monthly long-acting buprenorphine. This case adds to the evidence that HDBI may offer a feasible and clinically valuable approach for transitioning patients from high-dose methadone during the inpatient setting, where close monitoring and supportive care can be provided.<\/jats:p>","DOI":"10.1177\/29767342261418955","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T02:19:05Z","timestamp":1773454745000},"page":"917-922","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["High-Dose Buprenorphine Initiation to Rapidly Transition From High-Dose Methadone in the Hospital"],"prefix":"10.1177","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9753-4292","authenticated-orcid":false,"given":"Brent D.","family":"Schnipke","sequence":"first","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University and Northwestern Memorial Hospital, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0877-0618","authenticated-orcid":false,"given":"Zachary","family":"Bean","sequence":"additional","affiliation":[{"name":"University of Chicago Medical Center and Pritzker School of Medicine, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Social Work, Northwestern Memorial Hospital, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0846-6625","authenticated-orcid":false,"given":"Katherine","family":"Welter","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University and Northwestern Memorial Hospital, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4437-7622","authenticated-orcid":false,"given":"Melissa","family":"Bregger","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University and Northwestern Memorial Hospital, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7422-7772","authenticated-orcid":false,"given":"Lisa","family":"Blankenship","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine, Northwestern University and Northwestern Memorial Hospital, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2022.05.013"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.17128"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/adm.0000000000001296"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-018-3055-z"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1994.71"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.5055\/jom.2022.0752"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/adm.0000000000000855"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/adm.0000000000000396"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2025.104770"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-158-8-201304160-00001"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.3779"}],"container-title":["Substance Use &amp; Addiction Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/29767342261418955","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/29767342261418955","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/29767342261418955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:50:47Z","timestamp":1782467447000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/29767342261418955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,13]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/29767342261418955"],"URL":"https:\/\/doi.org\/10.1177\/29767342261418955","relation":{},"ISSN":["2976-7342","2976-7350"],"issn-type":[{"value":"2976-7342","type":"print"},{"value":"2976-7350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,13]]}}}