{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:22:24Z","timestamp":1783099344225,"version":"3.54.6"},"reference-count":11,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100018529","name":"Alkermes","doi-asserted-by":"publisher","award":["FIS-IIT-208"],"award-info":[{"award-number":["FIS-IIT-208"]}],"id":[{"id":"10.13039\/100018529","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Substance Use & Addiction Journal"],"abstract":"\n Background and Objectives:<\/jats:title>\n The current study investigates the roles of assertive outreach, individual participant involvement, and treatment significant other (TSO) involvement through the Medication Adherence Therapy: Psychosocial Leverage Using a Significant other (MAT-PLUS) intervention on extended-release naltrexone (XR-NTX) adherence for the treatment of opioid and\/or alcohol use disorder (OUD\/AUD).<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Participants receiving XR-NTX for OUD and\/or AUD received 16 weeks of the MAT-PLUS intervention through a prior randomized controlled trial (RCT). Logs tracked XR-NTX adherence, treatment team outreach, and participant\/family communications and sessions.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Of the contact types examined, only the number of family sessions attended significantly predicted next XR-NTX dose receipt (OR\u2009=\u20098.74, 95% CI [1.84, 54.41]) in\n n<\/jats:italic>\n \u2009=\u200912 participants.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Family involvement is an important component of OUD\/AUD treatment that may improve XR-NTX adherence.<\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration:<\/jats:title>\n \n Treatment of opioid use: Medication Adherence Therapy (MAT-PLUS),\n https:\/\/clinicaltrials.gov\/study\/NCT03567356?term=MAT-PLUS&rank=1<\/jats:ext-link>\n , NCT03567356\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/29767342261460423","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:42:33Z","timestamp":1782823353000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Assertive Outreach, Individual Involvement, and Significant Other Involvement on XR-NTX Adherence"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6632-9118","authenticated-orcid":false,"given":"Karen","family":"Guo","sequence":"first","affiliation":[{"name":"Maryland Treatment Centers, Baltimore, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6299-7569","authenticated-orcid":false,"given":"Kevin","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Maryland Treatment Centers, Baltimore, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5570-0737","authenticated-orcid":false,"given":"Julia","family":"Thomas","sequence":"additional","affiliation":[{"name":"Maryland Treatment Centers, Baltimore, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6764-6410","authenticated-orcid":false,"given":"Marc","family":"Fishman","sequence":"additional","affiliation":[{"name":"Maryland Treatment Centers, Baltimore, USA"},{"name":"Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Substance Abuse and Mental Health Services Administration. What is naltrexone? Side effects treatments & use. SAMHSA; 2025. Accessed January 9 2026. https:\/\/www.samhsa.gov\/substance-use\/treatment\/options\/naltrexone"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S277861"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11414-008-9136-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000496742"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/09595230500302356"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1037\/ccp0000495"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2021.108652"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.52.9.1223"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.josat.2024.209366"},{"key":"e_1_3_3_11_2","unstructured":"R Core Team. Version 4.4.2. R: A Language and Environment for Statistical Computing [computer software]. R Foundation for Statistical Computing; 2024. https:\/\/www.R-project.org\/"},{"key":"e_1_3_3_12_2","unstructured":"Posit Team. Version 2024.09.1+394. RStudio: Integrated Development Environment for R [Computer software]. Posit Software PBC; 2024. http:\/\/www.posit.co\/"}],"container-title":["Substance Use & Addiction Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/29767342261460423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/29767342261460423","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/29767342261460423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T16:49:47Z","timestamp":1783097387000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/29767342261460423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":11,"alternative-id":["10.1177\/29767342261460423"],"URL":"https:\/\/doi.org\/10.1177\/29767342261460423","relation":{},"ISSN":["2976-7342","2976-7350"],"issn-type":[{"value":"2976-7342","type":"print"},{"value":"2976-7350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"article-number":"29767342261460423"}}