{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:34:20Z","timestamp":1777883660961,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Substance Use: Research and Treatment"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The US Food and Drug Administration (FDA) issued a drug safety communication warning of dental-related adverse events (DAE) reported in patients using buprenorphine films or tablets in January 2022. This study utilized more recent data with a broader dental outcome definition beyond what has been previously reported to provide comprehensive evidence of this risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Assess the association between buprenorphine use and the risk of DAE among opioid use disorder (OUD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Using the Veradigm-MarketScan\u00ae linked dataset, adults aged \u2a7e18 years with an OUD diagnosis between June 30, 2018, and July 1, 2023, and who met our selection criteria were included. Patients were grouped as: (1) BUP users and (2) non-BUP users (control group). We used Prescription Time Distribution Matching (PTDM) and Inverse Probability Treatment Weighting (IPTW) methods to balance potential confounders between the 2 groups. The primary outcome was dental-related adverse events (DAE). Cox proportional hazards models estimated adjusted hazard ratios (HRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 14\u2009495 OUD adult patients were included. Of these patients, 4199 (28.97%) initiated oral buprenorphine. Among the overall population, most were males, 8742 (60.3%), with an average age of 44.9\u2009years. The absolute risk of DAE was slightly higher among buprenorphine users (2.17%) compared to controls (1.66%). We found an increased risk of DAE in buprenorphine users compared to the control group (adjusted HR, 1.36; 95%CI, 1.04-1.78).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>There is an increased risk of DAE among buprenorphine users compared to non-users after 6\u2009months of follow-up. Although this risk is modest, this finding suggests the need for increased awareness and preventive interventions among these users.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/29768357251411168","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T09:41:28Z","timestamp":1769593288000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Buprenorphine Use and the Risk of Dental Adverse Events in Patients With Opioid Use Disorder"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0789-0942","authenticated-orcid":false,"given":"Chijioke M.","family":"Okeke","sequence":"first","affiliation":[{"name":"The Prescription Drug Misuse Education and Research Center, College of Pharmacy, University of Houston, Houston, TX, USA"},{"name":"Department of Pharmaceutical Health Outcomes and Policy, College of Pharmacy, University of Houston, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Okonkwo","sequence":"additional","affiliation":[{"name":"The Prescription Drug Misuse Education and Research Center, College of Pharmacy, University of Houston, Houston, TX, USA"},{"name":"Department of Pharmaceutical Health Outcomes and Policy, College of Pharmacy, University of Houston, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olajumoke","family":"Olateju","sequence":"additional","affiliation":[{"name":"The Prescription Drug Misuse Education and Research Center, College of Pharmacy, University of Houston, Houston, TX, USA"},{"name":"Department of Pharmaceutical Health Outcomes and Policy, College of Pharmacy, University of Houston, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna Tumbas","family":"Saponjac","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashim","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansib","family":"Mursalin","sequence":"additional","affiliation":[{"name":"The Prescription Drug Misuse Education and Research Center, College of Pharmacy, University of Houston, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Douglas","family":"Thornton","sequence":"additional","affiliation":[{"name":"The Prescription Drug Misuse Education and Research Center, College of Pharmacy, University of Houston, Houston, TX, USA"},{"name":"Department of Pharmaceutical Health Outcomes and Policy, College of Pharmacy, University of Houston, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"Substance Abuse and Mental Health Services Administration (SAMHSA). Substance use disorder treatment options. 2025. 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Accessed August 9 2025. https:\/\/www.fda.gov\/safety\/medical-product-safety-information\/buprenorphine-drug-safety-communication-fda-warns-about-dental-problems-buprenorphine-medicines"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12709"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4812090"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jphd.12488"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000001453"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.17485"},{"key":"e_1_3_3_12_2","unstructured":"Federal Register: Practice guidelines for the administration of buprenorphine for treating opioid use disorder. Accessed November 2 2025. https:\/\/www.federalregister.gov\/documents\/2021\/04\/28\/2021-08961\/practice-guidelines-for-the-administration-of-buprenorphine-for-treating-opioid-use-disorder"},{"key":"e_1_3_3_13_2","unstructured":"U.S. Drug Enforcement Administration. Buprenorphine Treatment for Substance Use Disorder. 2024. Accessed August 9 2025. https:\/\/deadiversion.usdoj.gov\/pubs\/docs\/IQVIA-Buprenorphine-for-SUD-v3.pdf"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/BMJ.39335.541782.AD"},{"key":"e_1_3_3_15_2","unstructured":"Veradigm. Linked Claims + EHR Database by MarketScan\u00ae and Veradigm\u00ae. Accessed July 7 2025. https:\/\/lp.veradigm.com\/linked-claims-ehr-database"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/add.16338"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp080221"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.therap.2020.02.022"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000001458"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13295"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-019-00494-6"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi307"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv445"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/AJE\/KWM324"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/CKJ\/SFAB158"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5864"},{"key":"e_1_3_3_27_2","unstructured":"American Medical Association. AMA Overdose Epidemic Report. 2024. Accessed July 2 2025. https:\/\/www.ama-assn.org\/system\/files\/ama-overdose-epidemic-report.pdf"},{"key":"e_1_3_3_28_2","unstructured":"Buprenorphine Dispensing Rate Maps. Overdose Prevention. CDC. Accessed November 2 2025. https:\/\/www.cdc.gov\/overdose-prevention\/data-research\/facts-stats\/buprenorphine-dispensing-maps.html"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000001401"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1521-0391.2012.00254.x"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2022.109507"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000001292"},{"key":"e_1_3_3_33_2","unstructured":"National Institute of Dental and Craniofacial Research. Oral Health in America. 2021. 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