{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T11:42:04Z","timestamp":1792237324522,"version":"4.4.0"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Pediatrics"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Introduction<\/jats:italic>\n                    . Antibiotic overuse is a critical global health issue that drives antibiotic resistance, especially in low-income countries like Ethiopia, where data on prescribing practices are scarce.\n                    <jats:italic toggle=\"yes\">Objective<\/jats:italic>\n                    . This study assessed antimicrobial prescription patterns in pediatric patients at Dessie Comprehensive Specialized Hospital, Northeast Ethiopia.\n                    <jats:italic toggle=\"yes\">Methods<\/jats:italic>\n                    . A retrospective cross-sectional analysis of 171 pediatric inpatient prescriptions from March to April 2022 was conducted, using WHO pediatric guidelines and Ethiopia\u2019s Standard Treatment Guideline (STG) for evaluation.\n                    <jats:italic toggle=\"yes\">Results<\/jats:italic>\n                    . Among 157 analyzed prescriptions, most patients (55.4%) were hospitalized over 5\u2009days. Severe acute malnutrition (27.4%) and meningitis (14%) were the leading causes of admission. Ceftriaxone (51%) and augmentin (19%) were frequently prescribed, with inappropriate use noted in 10.2% of cases. Injectable antibiotics were used in 62.4% of prescriptions.\n                    <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>\n                    . Ceftriaxone was the primary antibiotic prescribed, with a generally rational prescribing pattern. However, additional attention to patients with comorbidities and rural backgrounds is advised.\n                  <\/jats:p>","DOI":"10.1177\/30502225251315062","type":"journal-article","created":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T02:46:06Z","timestamp":1740278766000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Antibiotic Prescription Trends Among Pediatric Patients in Dessie Comprehensive Specialized Hospital, Ethiopia"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8983-2986","authenticated-orcid":false,"given":"Yohannes","family":"Mengesha","sequence":"first","affiliation":[{"name":"Wollo University, Dessie, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sualih","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Wollo University, Dessie, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,22]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"Basic & Clinical Pharmacology","author":"Katzung BG","year":"2004","unstructured":"Katzung BG, Masters SB, Trevor AJ. Basic & Clinical Pharmacology. 8th ed. McGraw-Hill; 2004.","edition":"8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr190"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.7324\/JAPS.2018.8617"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-002285"},{"issue":"3","key":"e_1_3_3_6_2","first-page":"435","article-title":"Outpatient use of systemic antibiotics in Poland: 2004-2008","volume":"68","author":"Chlabicz M","year":"2014","unstructured":"Chlabicz M, Chlabicz S, Marcinowicz L, Rogowska-Szadkowska D, Pytel-Krolczuk B, Leszczy\u0144ska K. Outpatient use of systemic antibiotics in Poland: 2004-2008. Przegl Epidemiol. 2014;68(3):435-441.","journal-title":"Przegl Epidemiol"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/idr16040051"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13690-021-00624-1"},{"key":"e_1_3_3_9_2","unstructured":"World Health Organization. WHO operational package for assessing monitoring and evaluating country pharmaceutical situations: guide for coordinators and data collectors. Accessed June 15 2024. https:\/\/iris.who.int\/bitstream\/handle\/10665\/69927\/WHO_TCM_2007.2_eng"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00016-10"},{"key":"e_1_3_3_11_2","unstructured":"World Health Organization. Report of the 6th meeting of the WHO advisory group on integrated surveillance of antimicrobial resistance with AGISAR 5-year strategic framework to support implementation of the global action plan on antimicrobial resistance (2015-2019). Accessed June 15 2024. https:\/\/iris.who.int\/handle\/10665\/190954"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139097"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173290"},{"issue":"10","key":"e_1_3_3_14_2","first-page":"1184","article-title":"Assessment of prescribing practice pattern in governmental health centers of Bahir Dar Town, Ethiopia","volume":"2","author":"Bantie L.","year":"2014","unstructured":"Bantie L. Assessment of prescribing practice pattern in governmental health centers of Bahir Dar Town, Ethiopia. World J Pharm Sci. 2014;2(10):1184-1190.","journal-title":"World J Pharm Sci"},{"key":"e_1_3_3_15_2","unstructured":"World Health Organization. How to investigate drug use in health facilities: selected drug use indicators. WHO. 1993. Accessed July 25 2024. https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/60519\/WHO_DAP_93.1.pdf"},{"issue":"2","key":"e_1_3_3_16_2","first-page":"147","article-title":"Baseline survey on drug prescribing indicators for outpatients in Jimma University Specialized Hospital, Southwest Ethiopia","volume":"15","author":"Yenet W.","year":"2005","unstructured":"Yenet W. Baseline survey on drug prescribing indicators for outpatients in Jimma University Specialized Hospital, Southwest Ethiopia. Ethiop J Health Sci. 2005;15(2):147-156.","journal-title":"Ethiop J Health Sci"},{"key":"e_1_3_3_17_2","first-page":"1","article-title":"Pattern of parenteral antimicrobial prescription among pediatric\u200e patients in Al-Watani Governmental Hospital in Palestine","volume":"20","author":"Sawalha A","year":"2006","unstructured":"Sawalha A, Al-Bishtawi G, Al-Khayyat L, Jaradat N, Al-Ramahi R, Sweileh W. Pattern of parenteral antimicrobial prescription among pediatric\u200e patients in Al-Watani Governmental Hospital in Palestine. An-Najah Univ J Res (Sci). 2006;20:1-16.","journal-title":"An-Najah Univ J Res (Sci)"},{"key":"e_1_3_3_18_2","first-page":"4323769","article-title":"Retrospective assessment of antibiotics prescribing at public primary healthcare facilities in Addis Ababa, Ethiopia","volume":"1","author":"Worku F","year":"2018","unstructured":"Worku F, Tewahido D. Retrospective assessment of antibiotics prescribing at public primary healthcare facilities in Addis Ababa, Ethiopia. Interdiscip Persp Infect Dis. 2018;1:4323769.","journal-title":"Interdiscip Persp Infect Dis"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S262104"},{"issue":"15","key":"e_1_3_3_20_2","first-page":"214021","article-title":"Educational effectiveness, target, and content for prudent antibiotic use","volume":"20","author":"Lee CR","year":"2015","unstructured":"Lee CR, Lee JH, Kang LW, Jeong BC, Lee SH. Educational effectiveness, target, and content for prudent antibiotic use. BioMed Res Int. 2015;20(15):214021.","journal-title":"BioMed Res Int"},{"key":"e_1_3_3_21_2","unstructured":"Standard Treatment Guidelines for General Hospitals. Addis Ababa Ethiopia: Ethiopian Food Medicine and Healthcare Administration and Control Authority. 2014. Accessed May 22 2024. http:\/\/www.fmhaca.gov.et\/wp-content\/uploads\/2014\/03\/STGGeneral-Hospital.pdf"}],"container-title":["Sage Open Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/30502225251315062","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/30502225251315062","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/30502225251315062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T11:13:17Z","timestamp":1792235597000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/30502225251315062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":20,"alternative-id":["10.1177\/30502225251315062"],"URL":"https:\/\/doi.org\/10.1177\/30502225251315062","relation":{},"ISSN":["3050-2225","3050-2225"],"issn-type":[{"value":"3050-2225","type":"print"},{"value":"3050-2225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"article-number":"30502225251315062"}}