{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:32:46Z","timestamp":1777656766787,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Pediatrics"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate netrin-1 (NT-1) and neuron-specific enolase (NSE) in the umbilical cord as biomarkers in HIE stage II\/III.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We included 100 infants with HIE stage II\/III and 100 controls. Cord samples were taken to determine the levels of NT-1 and NSE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The HIE group showed significantly higher NT-1 (343.3\u2009\u00b1\u2009100.6\u2009pg\/mL) and NSE (55.17\u2009\u00b1\u200913.4\u2009ng\/mL;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.037,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.007, respectively) than the control group, which had NT-1 (268.1\u2009\u00b1\u200979.3\u2009pg\/mL) and NSE (31.3\u2009\u00b1\u200919.5\u2009ng\/mL). The cut-off values for NT-1 and NSE were 289.3\u2009pg\/mL and 31.9\u2009ng\/mL, respectively. NT-1 had a sensitivity of 92%, a specificity of 100%, a positive predictive value (PPV) of 94%, and a negative predictive value (NPV) of 100%. The sensitivity, specificity, PPV, and NPV for NSE were all 100%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>NT-1 and NSE can be reliable biomarkers for predicting HIE stage II\/III.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/30502225251321025","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T08:46:58Z","timestamp":1743065218000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Value of Netrin-1 and Neuron Specific Enolase biomarkers in neonates with Hypoxic \u0130schemic Encephalopathy"],"prefix":"10.1177","volume":"12","author":[{"given":"Ahmed","family":"Sobhi","sequence":"first","affiliation":[{"name":"Cairo University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf Hamed","family":"Al-shokary","sequence":"additional","affiliation":[{"name":"Benha University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moustafa Kotb","family":"Elmala","sequence":"additional","affiliation":[{"name":"Nizwa Hospital, Ad Dakhiliyah, Sultanate of Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha A.","family":"El faramawy","sequence":"additional","affiliation":[{"name":"Benha University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nageh Shehata","family":"Ismail","sequence":"additional","affiliation":[{"name":"Minia University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa Obada","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Ain Shams University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-3838","authenticated-orcid":false,"given":"Naglaa M.","family":"Kamal","sequence":"additional","affiliation":[{"name":"Cairo University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deena Yasir Hussein","family":"Omar","sequence":"additional","affiliation":[{"name":"Burjeel Medical City, Abu Dhabi, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Elrashed Elshaikh","family":"Eltayeb","sequence":"additional","affiliation":[{"name":"Department of Health, Abu Dhabi, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeer Abdel Kader Elsayed","family":"Abdel Mageed","sequence":"additional","affiliation":[{"name":"Burjeel Medical City, Abu Dhabi, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2219-3179","authenticated-orcid":false,"given":"Hatem Hamed","family":"Elshorbagy","sequence":"additional","affiliation":[{"name":"Menoufia University, Shebeen Elkom, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada Mohamed","family":"Abo Elela","sequence":"additional","affiliation":[{"name":"Benha University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar Ahmed","family":"Eletr","sequence":"additional","affiliation":[{"name":"Benha University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha Aguib Hassan","family":"Ali","sequence":"additional","affiliation":[{"name":"Benha University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci9030049"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2011.214205"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/46.3.155"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112066"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering9100498"},{"issue":"5","key":"e_1_3_3_7_2","article-title":"Neonatal encephalopathy and neurologic outcome","volume":"133","author":"The Task Force on Neonatal Encephalopathy, TheAmerican College of Obstetricians and Gynecologists","year":"2014","unstructured":"The Task Force on Neonatal Encephalopathy, TheAmerican College of Obstetricians and Gynecologists. 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