{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T06:35:20Z","timestamp":1780641320735,"version":"3.54.1"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Pediatrics"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To glean additional knowledge on children with fever of unknown origin (FUO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Children &lt;18\u2009years old referred to Infectious Disease Service for FUO in a tertiary paediatric hospital were analysed retrospectively from December 2004 to January 2019. Clinical profile, interventions and outcomes were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There were 272 children evaluated (median age 81.5\u2009months, 56.3% males). Causes identified were infections (54.0%), inflammatory (17.3%), haematology\/oncological (6.6%), others\/unknown (22.1%). The most common infection was typhoid fever. Kikuchi-Fujimoto Disease was the most common inflammatory cause, while haemophagocytic lymphohistiocytosis was the most common haematology\/oncological cause. Children\u2009\u2265\u20095\u2009years were more likely to have an inflammatory cause. Cough was associated with infections; mouth ulcers, joint pain and lymphadenopathy with inflammatory disorders. Hepatomegaly, splenomegaly, anaemia and raised C-reactive protein were associated with haematology\/oncological conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We provide insights into knowledge of paediatric FUO and identify clinical associations with infection, inflammatory and haematological\/oncological conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/30502225251321030","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T14:08:33Z","timestamp":1743689313000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Fever of Unknown Origin in Children: A 14-Year, Single Institution Retrospective 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