{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:47:50Z","timestamp":1785026870957,"version":"3.55.0"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Pediatrics"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\n                    Growth hormone deficiency (GHD) is a key differential diagnosis in children with proportionate short stature. While brain magnetic resonance imaging (MRI) is recommended for all confirmed GHD cases to rule out hypothalamic-pituitary anomalies, its universal application remains debated We conducted a retrospective, single-center study including 84 pediatric patients diagnosed with isolated GHD Brain MRI revealed hypothalamic-pituitary abnormalities in 27.4%. Compared to those with normal MRIs, patients with abnormalities were younger (6.78\u2009\u00b1\u20092.72 vs 8.34\u2009\u00b1\u20093.38\u2009years,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u2009.038), shorter (height SDS \u22122.83\u2009\u00b1\u20090.58 vs \u22122.56\u2009\u00b1\u2009.64,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u2009.032), and had lower IGF-1 SDS (\u22121.07\u2009\u00b1\u2009.66 vs \u2212.78\u2009\u00b1\u2009.70,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u2009.041). Multivariate logistic regression confirmed age, height SDS, and IGF-1 SDS as independent predictors of MRI anomalies. ROC analysis identified cutoff values with moderate predictive accuracy: age &lt;7.1\u2009years, height SDS &lt;\u22122.7, and IGF-1 SDS &lt;\u2212.9.\n                  <\/jats:p>","DOI":"10.1177\/30502225251378560","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:12:24Z","timestamp":1758795144000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of Hypothalamic\u2013Pituitary Abnormalities in Pediatric Patients with Growth Hormone Deficiency"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3711-4928","authenticated-orcid":false,"given":"Giorgio","family":"Sodero","sequence":"first","affiliation":[{"name":"Pediatric Unit, Azienda Sanitaria Locale di Brindisi, Perrino Hospital, Italy"},{"name":"Pediatric Endocrinology Unit, Perrino Hospital, Brindisi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi Antonio","family":"Moscogiuri","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Azienda Sanitaria Locale di Brindisi, Perrino Hospital, Italy"},{"name":"Pediatric Endocrinology Unit, Perrino Hospital, Brindisi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilea","family":"Lezzi","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Azienda Sanitaria Locale di Brindisi, Perrino Hospital, Italy"},{"name":"Pediatric Endocrinology Unit, Perrino Hospital, Brindisi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Comes","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Azienda Sanitaria Locale di Brindisi, Perrino Hospital, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Passoforte","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Azienda Sanitaria Locale 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