{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:34:02Z","timestamp":1777656842949,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Nestle Health Science"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Pediatrics"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>\n                    Amino acid-based formulas (AAF) contain free amino acids as their protein source and are indicated for certain gastrointestinal and medical conditions. When switching formulas, monitoring tolerance helps assure adequate nutritional management. A cross-sectional retrospective study was conducted using U.S. insurance claims data from 402 children switched from one AAF (Formula1) to a different AAF (Formula2) between June 2021\u2009and\u2009April 2023 during the nationwide formula shortage. Database was analyzed for age, sex, comorbidities, clinical symptoms, and healthcare encounters. Mean age was 5.3\u2009\u00b1\u20094.7\u2009years (60% male). Significantly fewer children experienced abdominal distention, diarrhea, flatulence, nausea\/vomiting, and allergy symptoms 1-, 3-, 6-months post-switch to Formula2 (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.05). Significant reductions for total mean adjusted costs, emergency department, inpatient, outpatient, urgent care, and telemedicine visits were observed 1-, 3-, and 6-months post-switch (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009&lt;\u2009.001). Children in post-acute care settings who transitioned to an alternate AAF (Formula2) experienced significantly improved clinical outcomes and reduced healthcare costs.\n                  <\/jats:p>","DOI":"10.1177\/30502225251380332","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:46:53Z","timestamp":1760608013000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Improved Impact on Clinical Outcomes and Reduced Cost of Care Associated With Switching Hypoallergenic Amino Acid-Based Formulas"],"prefix":"10.1177","volume":"12","author":[{"given":"Kalpesh H.","family":"Thakkar","sequence":"first","affiliation":[{"name":"Memorial Hermann Medical Group, Sugar Land, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-013X","authenticated-orcid":false,"given":"Pamela","family":"Cekola","sequence":"additional","affiliation":[{"name":"Nestl\u00e9 Health Science, Bridgewater, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jami","family":"Boccella","sequence":"additional","affiliation":[{"name":"Nestl\u00e9 Health Science, Bridgewater, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amarsinh","family":"Desai","sequence":"additional","affiliation":[{"name":"Nestl\u00e9 Health Science, Bridgewater, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Clarivate Data Analytics &amp; Insights, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayan","family":"Mondal","sequence":"additional","affiliation":[{"name":"Clarivate Data Analytics &amp; Insights, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yashashree","family":"Vijaykadam","sequence":"additional","affiliation":[{"name":"Clarivate Data Analytics &amp; Insights, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chidananda","family":"Samal","sequence":"additional","affiliation":[{"name":"Clarivate Data Analytics &amp; Insights, Bangalore, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6166-7373","authenticated-orcid":false,"given":"Abby","family":"Klosterbuer","sequence":"additional","affiliation":[{"name":"Nestl\u00e9 Health Science, Bridgewater, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-017-0182-z"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2023.1110380"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.11119"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/36.5.950"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.2.346"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2024.100947"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-016-0125-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003897"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2013.2376"},{"issue":"10","key":"e_1_3_3_11_2","first-page":"1","article-title":"Food allergy among U.S. children: trends in prevalence and hospitalizations","author":"Branum AM","year":"2008","unstructured":"Branum AM, Lukacs SL. 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