{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:56:40Z","timestamp":1790089000597,"version":"4.0.1"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Pediatrics"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Birth defects are a leading cause of neonatal mortality worldwide, particularly in low- and middle-income countries. In Latin America, longitudinal studies on BD prevalence and mortality remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To describe BD epidemiology in Bogot\u00e1 and Cali (2002-2019), focusing on prevalence, in-hospital mortality, and associated maternal and neonatal factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a retrospective, population-based cohort study using PREVERDEC surveillance data from 558\u2009057 births, following Latin American Collaborative Study of Congenital Malformations (ECLAMC) methodology. BD prevalence was expressed per 10\u2009000 live births, and Cox regression identified mortality risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>BD prevalence was 126.8 (95% CI: 123.9-129.8) per 10\u2009000 live births, with musculoskeletal anomalies most common. Neonatal mortality was 0.26 per 1000 live births. Mortality risk was higher in preterm infants, those with major BD, and circulatory system defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study provides updated evidence on BD in Colombia, highlighting risk factors for adverse outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/30502225251383338","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T09:15:19Z","timestamp":1761556519000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Birth Defects and Mortality-Related Factors in Colombia: Insights from a Surveillance Cohort (2002-2019)"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1861-767X","authenticated-orcid":false,"given":"Pablo","family":"Pineda-Sanabria","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8451-5041","authenticated-orcid":false,"given":"Esteban","family":"Portilla-Rojas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3526-2524","authenticated-orcid":false,"given":"Catalina","family":"Arbelaez-Hoyos","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1759-2877","authenticated-orcid":false,"given":"Valentina","family":"Baquero-Castro","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Lores","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Faculty of Medicine, Pontificia Universidad Javeriana, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Sarmiento","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Faculty of Medicine, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Zarante","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics, Pontificia Universidad Javeriana, Bogot\u00e1, Colombia"},{"name":"Hospital Universitario San Ignacio, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.664943"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3329\/bjch.v43i1.41218"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-90-481-9485-8_20"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31872"},{"key":"e_1_3_3_6_2","volume-title":"Defectos Cong\u00e9nitos: Periodo Epidemiol\u00f3gico IX. Colombia 2021","author":"Instituto Nacional de Salud","year":"2021","unstructured":"Instituto Nacional de Salud. Defectos Cong\u00e9nitos: Periodo Epidemiol\u00f3gico IX. Colombia 2021. Instituto Nacional de Salud; 2021."},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-023-04865-w"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.18502\/ijph.v51i5.9411"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000356568"},{"key":"e_1_3_3_10_2","unstructured":"Center for Disease Control. Congenital Anomalies. Centers for Disease Control and Prevention. December 29 2015. Accessed March 18 2024. https:\/\/www.cdc.gov\/ncbddd\/birthdefects\/surveillancemanual\/facilitators-guide\/module-1\/mod1-2.html"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70121-4"},{"key":"e_1_3_3_12_2","unstructured":"World Health Organization. WHO Recommendations on Antenatal Care for a Positive Pregnancy Experience. World Health Organization; 2016. Accessed October 11 2024. https:\/\/iris.who.int\/handle\/10665\/250796"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20211"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.14.04012"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20160108"},{"issue":"225","key":"e_1_3_3_16_2","first-page":"310","article-title":"Prevalence of congenital malformations among babies delivered at a tertiary care hospital","volume":"58","author":"Shrestha S","year":"2020","unstructured":"Shrestha S, Shrestha A. Prevalence of congenital malformations among babies delivered at a tertiary care hospital. JNMA J Nepal Med Assoc. 2020;58(225):310-313. doi:10.31729\/jnma.4985","journal-title":"JNMA J Nepal Med Assoc"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2019.08.006"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.6739"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5148"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.51481\/amc.v63i2.1185"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2022.10.002"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6603a4"},{"key":"e_1_3_3_23_2","unstructured":"Druschel C Hughes JP Olsen C. Mortality among infants with congenital malformations New York State 1983 to 1988. 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