{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:34:14Z","timestamp":1777656854969,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Pediatrics"],"published-print":{"date-parts":[[2025,2]]},"abstract":"\n Introduction:<\/jats:title>\n Dengue fever is a major pediatric health challenge, with thrombocytopenia as a key severity marker.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n To assess the predictive value of mean platelet volume, MPV-to-platelet ratio, and other complete blood count (CBC) indices for severe thrombocytopenia in pediatric dengue.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This prospective observational study enrolled 127 children (1 month\u201315\u2009years) with confirmed dengue at Hue Central Hospital, Vietnam (January 2023-July 2025). CBC parameters were measured on illness days 3 and 6. Severe thrombocytopenia was defined as platelet count <50\u2009000\/\u00b5L.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Severe thrombocytopenia occurred in 15.7% of patients. Day 3 MPV\/PLT ratio was the strongest predictor (median 0.10 vs 0.05,\n P<\/jats:italic>\n \u2009<\u2009.001; AUC 0.818; sensitivity 75.0%; specificity 88.8%). Elevated MPV, low platelet and lymphocyte counts were also significant. NLR showed moderate value, while PLR and SII were not predictive.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n MPV\/PLT is a simple, early marker for identifying high-risk children with dengue.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/30502225251388755","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T09:03:41Z","timestamp":1763370221000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictive Value of Mean Platelet Volume and Other CBC Indices for Thrombocytopenia in Pediatric Dengue Fever: A Prospective Observational Study"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3056-6086","authenticated-orcid":false,"given":"Chau Duc","family":"Nguyen-Huu","sequence":"first","affiliation":[{"name":"Hue University, University of Medicine and Pharmacy, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8912-620X","authenticated-orcid":false,"given":"Nhu-Huy","family":"Pham","sequence":"additional","affiliation":[{"name":"Midwestern University, Glendale, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi Lan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hue University, University of Medicine and Pharmacy, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quoc Bao","family":"Vo","sequence":"additional","affiliation":[{"name":"Hue University, University of Medicine and Pharmacy, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoang","family":"Le","sequence":"additional","affiliation":[{"name":"Hue University, University of Medicine and Pharmacy, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuan Tai","family":"Manh","sequence":"additional","affiliation":[{"name":"Hue University, University of Medicine and Pharmacy, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi Tam","family":"Dang","sequence":"additional","affiliation":[{"name":"Hue Central Hospital, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6652-9025","authenticated-orcid":false,"given":"Van-Tuy","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hue University, University of Medicine and Pharmacy, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"World Health Organization. Dengue and severe dengue: Key facts; 2024. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dengue-and-severe-dengue"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14161772"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010847"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0519-2020"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.56829"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43054-025-00345-y"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4274\/jcp.2024.62343"},{"key":"e_1_3_3_10_2","volume-title":"Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control: New Edition","author":"WHO Guidelines Approved by the Guidelines Review Committee","year":"2009","unstructured":"WHO Guidelines Approved by the Guidelines Review Committee. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control: New Edition. World Health Organization 2009."},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-025-10486-5"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.24966\/HBTD-2999\/100026"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2021.1902967"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep41697"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2024\/68904.19162"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000718"},{"key":"e_1_3_3_17_2","first-page":"5","article-title":"Ratio of neutrophil to lymphocyte counts\u2013rapid and simple parameter of systemic inflammation and stress in critically ill","volume":"102","author":"Zahorec R.","year":"2001","unstructured":"Zahorec R. Ratio of neutrophil to lymphocyte counts\u2013rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102:5-14.","journal-title":"Bratisl Lek Listy"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.18203\/2349-3933.ijam20210601"}],"container-title":["Sage Open Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/30502225251388755","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/30502225251388755","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/30502225251388755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:07:31Z","timestamp":1777446451000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/30502225251388755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":17,"alternative-id":["10.1177\/30502225251388755"],"URL":"https:\/\/doi.org\/10.1177\/30502225251388755","relation":{},"ISSN":["3050-2225","3050-2225"],"issn-type":[{"value":"3050-2225","type":"print"},{"value":"3050-2225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"article-number":"30502225251388755"}}