{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T17:35:31Z","timestamp":1777656931867,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Sage Open Pediatrics"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Arginine can stimulate growth hormone production. However, a synthesis of the evidence on the effect in children\u2019s height is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To systematically evaluate the efficacy of oral arginine in improving height in prepubertal children with idiopathic short stature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Systematic review and meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources and methods:<\/jats:title>\n                    <jats:p>We included clinical trials and cohort studies. We searched in 7 databases until May 31, 2025. Effects were pooled using standardized mean differences (SMDs) and re-expressed as mean differences (MDs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We only found low-quality studies. Oral arginine administered for 6 or 12\u2009months increased growth velocity (SMD 0.66, 95% CI 0.21-1.12), but the benefit was clinically small (re-expressed MD 0.59\u2009cm\/year [95% CI 0.19-1.00]), and the effect was not statistically significant when administered for exclusively 12\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Oral arginine administered for 12\u2009months may not affect growth. Well-designed RCTs are required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration:<\/jats:title>\n                    <jats:p>PROSPERO (CRD42024503778).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/30502225261433767","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:33:09Z","timestamp":1774528389000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Oral Arginine as Treatment to Improve Height in Prepubertal Children With Idiopathic Short Stature: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6637-6463","authenticated-orcid":false,"given":"Manuel Andr\u00e9","family":"Vir\u00fa-Loza","sequence":"first","affiliation":[{"name":"Universidad San Ignacio de Loyola, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3292-3160","authenticated-orcid":false,"given":"Ruth Elizabeth","family":"Ch\u00e1vez-Nomberto","sequence":"additional","affiliation":[{"name":"Hospital Nacional Docente Madre Ni\u00f1o San Bartolom\u00e9, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9999-4003","authenticated-orcid":false,"given":"Adrian V.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Universidad San Ignacio de Loyola, Lima, Peru"},{"name":"University of Connecticut School of Pharmacy, Storrs, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.m2023.0247"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.51866\/rv1157"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8739289"},{"issue":"6","key":"e_1_3_2_5_2","first-page":"509","article-title":"Controlled clinical assay in clonidine, arginine aspartate, alpha-ketoglutarate of ornithine and ciproheptadine as growth stimulants in children with short stature","volume":"38","author":"Herranz Jord\u00e1n B","year":"1993","unstructured":"Herranz Jord\u00e1n B, Moreno Romero F, Cardesa Garc\u00eda JJ, Santos Hurtado I, Aparicio Palomino A, Requena Guerrero F. [Controlled clinical assay in clonidine, arginine aspartate, alpha-ketoglutarate of ornithine and ciproheptadine as growth stimulants in children with short stature]. An Esp Pediatr. 1993;38(6):509-515.","journal-title":"An Esp Pediatr"},{"issue":"1","key":"e_1_3_2_6_2","first-page":"61","article-title":"Therapy with arginine chlorohydrate in children with short constitutional stature","volume":"45","author":"Pittari AM","year":"1993","unstructured":"Pittari AM, Becherucci P, La Cauza F, Seminara S. [Therapy with arginine chlorohydrate in children with short constitutional stature]. Minerva Pediatr. 1993; 45(1-2):61-65.","journal-title":"Minerva Pediatr"},{"issue":"11","key":"e_1_3_2_7_2","first-page":"449","article-title":"Use of arginine hydrochloride in non-endocrine growth disorders","volume":"42","author":"Saggese G","year":"1990","unstructured":"Saggese G, Cesaretti G, Ghirri P. [Use of arginine hydrochloride in non-endocrine growth disorders]. 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