{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:05:17Z","timestamp":1791295517254,"version":"4.1.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>Alexander disease is a rare, sporadic leukoencephalopathy characterized by white-matter abnormalities with frontal predominance and, as a rule, clinically associated with megalencephaly, seizures, spasticity, and psychomotor deterioration. We describe a boy who was diagnosed as affected by anorexia nervosa because of his refusal to eat, progressive weight loss, and psychologic disturbances. The observation of a hyperintense lesion on T2-weighed magnetic resonance images (MRIs) was initially explained as a pontine and extrapontine myelinolysis related to malnutrition. Following MRI and DNA analysis, we diagnosed a juvenile type of Alexander disease. Therefore, we can affirm the importance of the history and clinical examination to look for brainstem dysfunction in patients presenting with atypical anorexia nervosa.<\/jats:p>","DOI":"10.1177\/7010.2006.00235","type":"journal-article","created":{"date-parts":[[2007,2,27]],"date-time":"2007-02-27T17:50:05Z","timestamp":1172598605000},"page":"1075-1080","source":"Crossref","is-referenced-by-count":10,"title":["Unusual Diagnosis in a Child Suffering From Juvenile Alexander Disease: Clinical and Imaging Report"],"prefix":"10.1177","volume":"21","author":[{"given":"Emilio","family":"Franzoni","sequence":"first","affiliation":[{"name":"Child Neuropsychiatry Unit Department of Pediatrics University of Bologna Bologna, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjo S.","family":"Van der Knaap","sequence":"additional","affiliation":[{"name":"Department of Child Neurology VU University Medical Center Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Errani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Colonnelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Bracceschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Malaspina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena Caterina","family":"Moscano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Garone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasenka","family":"Sarajlija","sequence":"additional","affiliation":[{"name":"Child Neuropsychiatry Unit Department of Pediatrics University of Bologna Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gajja S.","family":"Salomons","sequence":"additional","affiliation":[{"name":"Metabolic Unit Department of Clinical Chemistry VU University Medical Center Amsterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Bernardi","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Bellaria Hospital, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2006,12,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/72.3.373"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-7479"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2003.09.004"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(03)00132-3"},{"key":"atypb5","first-page":"541","volume":"22","author":"Van der Knaap MS","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1038\/83679"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20381"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20406"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(02)00411-3"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.3.353"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1177\/088307380201700615"},{"key":"atypb12","volume-title":"Normal Myelination, Demyelination, and Dysmelinating Diseases in Pediatrics","author":"Zimmerman RA","year":"2000"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10382"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(02)00080-3"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1177\/088307389000500323"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.6.807"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-195907000-00001"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1007\/s100380170024"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1086\/323799"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1177\/088307380201700316"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(02)00167-5"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/7010.2006.00235","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/7010.2006.00235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:32:47Z","timestamp":1777494767000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/7010.2006.00235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1177\/7010.2006.00235"],"URL":"https:\/\/doi.org\/10.1177\/7010.2006.00235","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}