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Additional references were identified from a review of literature citations.\n                    <jats:bold>Study Selection and Data Extraction<\/jats:bold>\n                    : All English-language original research and review reports were evaluated.\n                    <jats:bold>Data Synthesis:<\/jats:bold>\n                    IPPV is a common supportive care measure for critically ill patients. While lifesaving, IPPV is associated with significant complications including ventilator-associated pneumonia, sinusitis, organ dysfunction, and hemodynamic alterations. Optimization of pain and sedation management provides an opportunity for pharmacists to directly affect IPPV exposure. A number of pharmacotherapeutic interventions are related directly to prophylaxis against IPPV-associated adverse events or aimed at reduction of duration of IPPV.\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Enhanced knowledge of the common complications, associated pharmacotherapy, and monitoring strategies facilitate the pharmacist\u2019s ability to provide increased pharmacotherapeutic insight in a multidisciplinary intensive care unit setting.\n                  <\/jats:p>","DOI":"10.1177\/8755122518766594","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T05:43:06Z","timestamp":1522302186000},"page":"153-170","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Complications and Pharmacologic Interventions of Invasive Positive Pressure Ventilation During Critical Illness"],"prefix":"10.1177","volume":"34","author":[{"given":"Andrea Sikora","family":"Newsome","sequence":"first","affiliation":[{"name":"The University of Georgia, Augusta, GA, USA"},{"name":"Augusta University Medical Center, Augusta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4018-0195","authenticated-orcid":false,"given":"Daniel B.","family":"Chastain","sequence":"additional","affiliation":[{"name":"The University of Georgia, Augusta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paige","family":"Watkins","sequence":"additional","affiliation":[{"name":"Augusta University Medical Center, Augusta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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