{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:09:14Z","timestamp":1784783354268,"version":"3.55.0"},"reference-count":11,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T00:00:00Z","timestamp":1692403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Technology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>\n                    Background: Neuromuscular blocking agents are one of the few medication classes that have demonstrated a clinical benefit in patients with severe acute respiratory distress syndrome (ARDS). However, most literature utilized cisatracurium, and utilization of atracurium is limited to 1 small study. Objective: The purpose of this study was to provide further evidence comparing the safety and efficacy of atracurium versus cisatracurium for the treatment of ARDS. Methods: This multicenter, retrospective, observational cohort noninferiority study was conducted at 3 hospitals within a tertiary health care system. We included subjects diagnosed with ARDS who received either atracurium or cisatracurium for at least 12\u2009hours. The primary outcome measured the change in PaO\n                    <jats:sub>2<\/jats:sub>\n                    \/FiO\n                    <jats:sub>2<\/jats:sub>\n                    (P\/F) ratio from baseline to 48\u2009hours after initiation. Results: Baseline characteristics were similar between groups except for a higher median age and a higher proportion of subjects who were COVID-positive in the atracurium group. There were also some noted differences in the baseline P\/F ratios. In a multivariable model adjusting for baseline characteristics, the change in the P\/F ratio for atracurium was noninferior to cisatracurium at 24, 48, and 72\u2009hours. A significant cost reduction, measured as cost per patient per day, was seen with the use of atracurium ($14.81-$25.16 vs $33.86-$41.91). Conclusion: Atracurium appears to be a safe and cheaper alternative agent in the management of ARDS.\n                  <\/jats:p>","DOI":"10.1177\/87551225231194031","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T06:02:22Z","timestamp":1692424942000},"page":"212-217","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Atracurium Versus Cisatracurium in the Treatment of Acute Respiratory Distress Syndrome"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3571-5017","authenticated-orcid":false,"given":"Shannon M.","family":"Carabetta","sequence":"first","affiliation":[{"name":"Ascension St. Vincent\u2019s Riverside, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7307-0630","authenticated-orcid":false,"given":"Bryan","family":"Allen","sequence":"additional","affiliation":[{"name":"Ascension St. Vincent\u2019s Riverside, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Cannon","sequence":"additional","affiliation":[{"name":"Ascension St. Vincent\u2019s Riverside, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3087-6698","authenticated-orcid":false,"given":"Kirubel","family":"Hailu","sequence":"additional","affiliation":[{"name":"Ascension St. Vincent\u2019s Riverside, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Totty","family":"Johnson","sequence":"additional","affiliation":[{"name":"Ascension St. Vincent\u2019s Riverside, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,8,19]]},"reference":[{"key":"bibr1-87551225231194031","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60331"},{"key":"bibr2-87551225231194031","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.06.62"},{"key":"bibr3-87551225231194031","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2018.10.019"},{"key":"bibr4-87551225231194031","doi-asserted-by":"publisher","DOI":"10.1177\/1060028020910132"},{"key":"bibr5-87551225231194031","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-2765-2"},{"key":"bibr6-87551225231194031","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05102"},{"key":"bibr7-87551225231194031","unstructured":"Atracurium. Lexi-drugs. Lexicomp. Published July 11, 2023. Accessed August 2, 2023. http:\/\/online.lexi.com\/"},{"key":"bibr8-87551225231194031","unstructured":"Cisatracurium. Lexi-drugs. Lexicomp. Published June 27, 2023. Accessed August 2, 2023. http:\/\/online.lexi.com\/"},{"key":"bibr9-87551225231194031","first-page":"2","volume":"17","author":"Superior spreadsheet solutions offered with SAS\/CALC software","year":"1991","journal-title":"SAS Commun"},{"key":"bibr10-87551225231194031","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005372"},{"key":"bibr11-87551225231194031","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1901686"}],"container-title":["Journal of Pharmacy Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/87551225231194031","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/87551225231194031","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/87551225231194031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:31:57Z","timestamp":1777602717000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/87551225231194031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,19]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1177\/87551225231194031"],"URL":"https:\/\/doi.org\/10.1177\/87551225231194031","relation":{},"ISSN":["8755-1225","1549-4810"],"issn-type":[{"value":"8755-1225","type":"print"},{"value":"1549-4810","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,19]]}}}