{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T08:20:26Z","timestamp":1778401226810,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100026326","name":"American Society of Health-System Pharmacists","doi-asserted-by":"publisher","award":["Resident Research grant"],"award-info":[{"award-number":["Resident Research grant"]}],"id":[{"id":"10.13039\/100026326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Technology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>To evaluate judicious antibiotic prescribing of benzathine penicillin G (BPG) after implementation of an electronic health record-based medication shortage alert during a critical drug shortage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This was an institutional review board\u2013approved retrospective cohort study of patients aged \u22653 months who received BPG between May 9, 2023, and February 28, 2024. The study included inpatient and outpatient visits after implementing a BPG medication shortage alert; patients with severe penicillin allergy, neurosyphilis, or congenital syphilis were excluded. Judicious BPG use was defined as use in patients diagnosed with primary, secondary, or latent syphilis or if they were prescribed a BPG alternative in response to the medication shortage alert; nonjudicious use included BPG for alternative diagnoses. Social determinants of health were assessed as exposure variables of interest. A separate cohort of syphilis patients receiving BPG or alternative therapy (i.e., doxycycline) was described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 453 patients were included. Most patients were non-Hispanic Black (n = 273, 60%) men (n = 272, 60%) with a median (interquartile range) age of 32 (22\u201344) years. Of these, 318 (70%) received judicious BPG, whereas 135 (30%) received nonjudicious BPG. The most nonjudicious diagnosis was streptococcal pharyngitis (n = 128, 95%). Variables associated with judicious use included age &gt;32 years (adjusted odds ratio [adjOR], 2.273; 95% CI, 1.488\u20133.472), male sex (adjOR, 1.835; 95% CI, 1.206\u20132.792), and black race (adjOR, 1.847; 95% CI, 1.212\u20132.815). Among a cohort of 128 syphilis patients who received BPG (n = 64, 50%) or doxycycline (n = 64, 50%), those who received doxycycline were more likely be uninsured (35 [54.7%] vs 43 [67.2%]; P = .15) and receive outpatient treatment (3 [4.7%] vs 12 [18.7%]; P = .13).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Despite implementing an electronic health record drug shortage alert, 30% of BPG use was nonjudicious and mostly for pharyngitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/87551225241285317","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T08:00:41Z","timestamp":1728633641000},"page":"3-7","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Judicious Use of Benzathine Penicillin G in Response to a Medication Alert During a Critical Drug Shortage"],"prefix":"10.1177","volume":"41","author":[{"given":"William","family":"Campillo Terrazas","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Henry Ford Hospital, Detroit, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel M.","family":"Kenney","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Henry Ford Hospital, Detroit, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Argyris","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Henry Ford Hospital, Detroit, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita B.","family":"Shallal","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Henry Ford Hospital, Detroit, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5967-5211","authenticated-orcid":false,"given":"Michael P.","family":"Veve","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Henry Ford Hospital, Detroit, MI"},{"name":"Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"bibr1-87551225241285317","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir954"},{"key":"bibr2-87551225241285317","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix379"},{"key":"bibr3-87551225241285317","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy068"},{"key":"bibr4-87551225241285317","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2013.19.9.783"},{"key":"bibr5-87551225241285317","doi-asserted-by":"publisher","DOI":"10.1197\/jamia.M1531"},{"key":"bibr6-87551225241285317","unstructured":"Ha M. Navigating drug shortages with real-time surveillance technology. Wolters Kluwer Health. Accessed June 22, 2024. https:\/\/www.wolterskluwer.com\/en\/expert-insights\/navigating-drug-shortages-with-real-time-surveillance-technology"},{"key":"bibr7-87551225241285317","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1740257"},{"key":"bibr8-87551225241285317","unstructured":"American Society of Hospital Pharmacists. Drug Shortage Detail: Penicillin G Benzathine. Accessed June 22, 2023. https:\/\/www.ashp.org\/Drug-Shortages\/Current-Shortages\/Drug-Shortage-Detail.aspx?id=909"},{"key":"bibr9-87551225241285317","unstructured":"American Society of Hospital Pharmacists. Drug Shortage Detail: Amoxicillin Oral Presentations. Accessed August 16, 2023. https:\/\/www.ashp.org\/Drug-Shortages\/Current-Shortages\/Drug-Shortage-Detail.aspx?id=875"},{"key":"bibr10-87551225241285317","unstructured":"Centers for Disease Control and Prevention. Syphilis\u2014STI Treatment Guidelines. Accessed July 22, 2023. https:\/\/www.cdc.gov\/std\/treatment-guidelines\/syphilis.htm"},{"key":"bibr11-87551225241285317","unstructured":"Centers for Disease Control and Prevention. National Overview of STDs 2021. Accessed June 22, 2023. https:\/\/www.cdc.gov\/std\/statistics\/2021\/overview.htm#Syphilis"},{"key":"bibr12-87551225241285317","unstructured":"Michigan Department of Health and Human Services. Sexually Transmitted Diseases. Accessed July 7, 2023. https:\/\/www.michigan.gov\/mdhhs\/inside-mdhhs\/statisticsreports\/communicable-diseases\/sexually-transmitted-infections"},{"key":"bibr13-87551225241285317","unstructured":"Centers for Disease Control and Prevention. Social Determinants of Health (SDOH). Accessed June 19, 2024. https:\/\/www.cdc.gov\/about\/priorities\/why-is-addressing-sdoh-important.html"},{"key":"bibr14-87551225241285317","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofad368"},{"key":"bibr15-87551225241285317","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-021-03399-2"},{"key":"bibr16-87551225241285317","doi-asserted-by":"publisher","DOI":"10.1177\/0033354918774788"},{"key":"bibr17-87551225241285317","doi-asserted-by":"publisher","DOI":"10.1093\/jamia\/ocaa143"}],"container-title":["Journal of Pharmacy Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/87551225241285317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/87551225241285317","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/87551225241285317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:32:47Z","timestamp":1777602767000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/87551225241285317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,11]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1177\/87551225241285317"],"URL":"https:\/\/doi.org\/10.1177\/87551225241285317","relation":{},"ISSN":["8755-1225","1549-4810"],"issn-type":[{"value":"8755-1225","type":"print"},{"value":"1549-4810","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,11]]}}}