{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:57:25Z","timestamp":1787237845290,"version":"build-2736575974"},"reference-count":16,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Technology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    HIV treatment has advanced significantly with the introduction of simpler antiretroviral regimens, but adherence remains a challenge. In this context, the long-acting injectable combination cabotegravir\/rilpivirine (CAB\/RPV) emerges as a promising alternative to improve adherence and quality of life for patients.\n                    <jats:bold>Objective<\/jats:bold>\n                    : The purpose of this study was to determine the proportion of patients with HIV-1 on antiretroviral therapy (ART) who meet the criteria for the use of intramuscular CAB\/RPV.\n                    <jats:bold>Methods<\/jats:bold>\n                    : A single-center, retrospective observational study was conducted on patients with HIV-1 receiving ART at a Spanish hospital. Adult patients with at least 6 months of stable ART and a viral load result in the previous 12 months were included. Pregnant women, patients with less than 6 months of ART, or those without a recent viral load were excluded. The primary endpoint was the proportion of patients meeting the criteria for intramuscular CAB\/RPV: undetectable viral load, stable ART, adherence &gt;90%, no resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs)\/integrase strand transfer inhibitors (INSTIs), no enzyme inducers, no anticoagulants, and no hepatitis B virus (HBV) infection. We also measure the risk of virological failure. Costs and treatment complexity were analyzed.\n                    <jats:bold>Results<\/jats:bold>\n                    : A total of 194 patients were included. In total, 68% met the criteria for intramuscular CAB\/RPV. The main reasons for ineligibility were a recent ART switch (16%) and lack of adherence (11.3%). The mean annual incremental cost per patient when switching to CAB\/RPV was \u20ac651.51.\n                    <jats:bold>Conclusion and Relevance<\/jats:bold>\n                    : A considerable proportion of patients with HIV meet the criteria for intramuscular CAB\/RPV. However, lack of adherence and the costs associated with intramuscular therapy represent barriers to its implementation. Strategies to improve adherence and cost-effectiveness studies are needed.\n                  <\/jats:p>","DOI":"10.1177\/87551225251333698","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T06:09:51Z","timestamp":1746684591000},"page":"159-164","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Eligibility for Intramuscular Cabotegravir\/Rilpivirine in HIV-Positive Patients: An Observational Study"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5003-911X","authenticated-orcid":false,"given":"Gabriel","family":"Mart\u00ednez-Orea","sequence":"first","affiliation":[{"name":"Pharmacy Service, Hospital Vega Baja of Orihuela, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7149-1308","authenticated-orcid":false,"given":"Francisco Jos\u00e9","family":"Rodr\u00edguez-Lucena","sequence":"additional","affiliation":[{"name":"Pharmacy Service, Hospital Vega Baja of Orihuela, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Fuentes-Hidalgo","sequence":"additional","affiliation":[{"name":"Pharmacy Service, Hospital Vega Baja of Orihuela, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"del-Moral-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Pharmacy Service, Hospital Vega Baja of Orihuela, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustina","family":"Ruiz-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Pharmacy Service, Hospital Vega Baja of Orihuela, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Arroyo-Domingo","sequence":"additional","affiliation":[{"name":"Pharmacy Service, Hospital Vega Baja of Orihuela, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(17)30066-8"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000298"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0956462418813047"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31917-7"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(20)30340-4"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1904398"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(21)00185-5"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/25787489.2019.1661696"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1060028016656385"},{"key":"e_1_3_2_11_2","unstructured":"State Agency Official State Gazette. Ley 37\/1992 de 28 de diciembre del Impuesto sobre el Valor A\u00f1adido. Available from: https:\/\/www.boe.es\/buscar\/act.php?id=BOE-A-1992-28740"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2023.07.006"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27890"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003361"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","unstructured":"Juan Andr\u00e9s AM Jorge Iv\u00e1n EA Alberto GC et al Factores relacionados con la no adherencia a la terapia antirretroviral en pacientes con VIH\/sida. Farm Hosp. [Internet]. 2022;46(6):319-326. doi:10.7399\/fh.11793. Accessed June 23 2023. http:\/\/scielo.isciii.es\/scielo.php?script=sci_arttext&pid=S1130-63432022000600002&lng=es","DOI":"10.7399\/fh.11793"},{"issue":"5","key":"e_1_3_2_16_2","first-page":"458","article-title":"Determination of a cutoff value for medication regimen complexity index to predict polypharmacy in HIV+ older patient","volume":"32","author":"Morillo-Verdugo R","year":"2019","unstructured":"Morillo-Verdugo R, Robustillo-Cort\u00e9s MA, Abdel-Kader Mart\u00edn L, \u00c1lvarez de Sotomayor Paz M, Lozano de Le\u00f3n Naranjo F, Almeida Gonz\u00e1lez CV. Determination of a cutoff value for medication regimen complexity index to predict polypharmacy in HIV+ older patient. Rev Esp Quimioter. 2019;32(5):458-464.","journal-title":"Rev Esp Quimioter"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-023-00840-y"}],"container-title":["Journal of Pharmacy Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/87551225251333698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/87551225251333698","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/87551225251333698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:33:13Z","timestamp":1777602793000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/87551225251333698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,8]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1177\/87551225251333698"],"URL":"https:\/\/doi.org\/10.1177\/87551225251333698","relation":{},"ISSN":["8755-1225","1549-4810"],"issn-type":[{"value":"8755-1225","type":"print"},{"value":"1549-4810","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,8]]}}}