{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:11:24Z","timestamp":1784304684730,"version":"3.55.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Technology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    Methicillin-resistant\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    pneumonia (PNA) can be ruled out via methicillin-resistant\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    (MRSA) culture and polymerase chain reaction (PCR) nasal screening, facilitating the de-escalation of empiric anti-MRSA agents like intravenous vancomycin. This study evaluated the impact of transitioning from culture to PCR-based MRSA nasal screening in patients with PNA.\n                    <jats:bold>Methods:<\/jats:bold>\n                    This Institutional Review Board (IRB)-approved retrospective quasi-experimental study was conducted at a 5-hospital system and included adult, nonpregnant hospitalized patients from September to December 2021 (\u201cculture group\u201d) and September to December 2022 (\u201cPCR group\u201d) and diagnosed with PNA. Exclusion criteria were ventilator-acquired PNA or positive MRSA respiratory culture. The primary endpoint was the number of vancomycin levels obtained. Secondary endpoints were vancomycin duration as well as acute kidney injury (AKI) and all-cause 30-day readmission rates.\n                    <jats:bold>Results:<\/jats:bold>\n                    Two-hundred patients were included: 100 in each group. Baseline characteristics were similar. There were 117 vancomycin levels obtained: 67 (67) and 50 (50) in the culture and PCR group, respectively (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .021). Median vancomycin duration was 50% shorter in the PCR group: 2 days (1-3) versus 3 days (2-4),\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001. After adjusting for confounders, the culture group was more likely to have vancomycin levels obtained compared to the PCR group: adjusted odd ratio (aOR) (95% confidence interval [CI])] = 1.833 (1.016\u20133.309). Long-term obstructive pulmonary disease was associated with reduced risk of ordering vancomycin levels: aOR [95% CI] = 0.426 (0.218-0.831). Readmission and AKI rates were comparable.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Transitioning from culture to PCR-based MRSA nasal screening significantly reduced vancomycin levels obtained from patients and shortened vancomycin duration without negatively impacting patient outcome.\n                  <\/jats:p>","DOI":"10.1177\/87551225251359508","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:08:21Z","timestamp":1754482101000},"page":"255-261","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Methicillin-Resistant\n                    <i>Staphylococcus aureus<\/i>\n                    Nasal PCR Versus Culture on Vancomycin Utilization in Pneumonia Management"],"prefix":"10.1177","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4885-2352","authenticated-orcid":false,"given":"Surafel G.","family":"Mulugeta","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Henry Ford Health System, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Kantharia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Henry Ford Health System, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Veve","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Henry Ford Health System, Detroit, MI, USA"},{"name":"Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaina","family":"Vincent","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Henry Ford Health System, Detroit, MI, 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