{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:06:49Z","timestamp":1780369609272,"version":"3.54.1"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Technology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The optimal treatment duration for uncomplicated vancomycin-resistant\n                    <jats:italic toggle=\"yes\">Enterococcus<\/jats:italic>\n                    (VRE) bacteremia is unclear. Shorter courses may reduce adverse events (AEs) and hospital length of stay (LOS) without compromising clinical outcomes.\n                    <jats:bold>Objective:<\/jats:bold>\n                    To evaluate clinical outcomes associated with short-course (\u22646 days) vs long-course (&gt;6 days) therapy in hospitalized adults with uncomplicated VRE bacteremia.\n                    <jats:bold>Methods:<\/jats:bold>\n                    We conducted a single-center, retrospective study of adults with uncomplicated VRE bacteremia between 2014 and 2024. Patients who received \u22646 days of definitive antibiotic therapy were compared with those who received &gt;6 days. The primary outcome was 30-day bacteremia recurrence. Secondary outcomes included infection-related readmission, 30- and 90-day all-cause mortality, post-bacteremia hospital LOS, and antibiotic-related AEs. Descriptive statistics, chi-square, and Fisher\u2019s exact tests were used.\n                    <jats:bold>Results:<\/jats:bold>\n                    Of the 48 patients included, 10 received short-course therapy and 38 received long-course, with median treatment durations of 5 days (interquartile range [IQR] 4-6) and 12 days (IQR 6-18), respectively. No recurrences were observed in either group. Infection-related readmissions occurred only in the long-course group (7.9%, n = 3;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.49). Thirty-day mortality rates were 30% (short-course) vs 21.1% (long-course;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.41), and the 90-day mortality rates were 30% vs 29%, respectively. Median post-bacteremia hospital LOS was shorter in the short-course group (10.5 vs 13 days;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.68). The AEs were similar between groups.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    In this small exploratory cohort, short-course therapy (\u22646 days) for uncomplicated VRE bacteremia was not associated with higher recurrence, readmission, or mortality than longer courses. These hypothesis-generating results support further studies on abbreviated treatments in carefully selected patients.\n                  <\/jats:p>","DOI":"10.1177\/87551225251396748","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T07:24:51Z","timestamp":1766129091000},"page":"91-97","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Short-Course Therapy for Uncomplicated VRE Bacteremia: This is Us Trying (to Shorten Therapy)"],"prefix":"10.1177","volume":"42","author":[{"given":"Eleazar","family":"Torres","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of New Mexico Hospital, Albuquerque, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Hlavacek","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of New Mexico Hospital, Albuquerque, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5402-0240","authenticated-orcid":false,"given":"M. Gabriela","family":"Cabanilla","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of New Mexico Hospital, Albuquerque, NM, USA"},{"name":"Division of Infectious Diseases, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"CDC. Antimicrobial resistance threats in the United States 2021-2022. Antimicrobial Resistance. August 12 2024. Accessed September 8 2024. https:\/\/www.cdc.gov\/antimicrobial-resistance\/data-research\/threats\/update-2022.html"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2761"},{"key":"e_1_3_3_4_2","first-page":"2669","volume-title":"Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases","author":"Nelson GGM","year":"2020","unstructured":"Nelson GGM. Chapter 218: enterobacteriaceae. In: Blaser MJ, Cohen JI, Holland SM. Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020:2669-2685.","edition":"9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.10.029"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/599376"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2019.10.008"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2404991"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2022.08.023"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1710926"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1808312"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2022.08.024"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2024.106313"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy1054"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlac058"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.09.001"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.6348"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000339789"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00900-18"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.442"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/10600280241260146"}],"container-title":["Journal of Pharmacy Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/87551225251396748","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/87551225251396748","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/87551225251396748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:33:43Z","timestamp":1777602823000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/87551225251396748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1177\/87551225251396748"],"URL":"https:\/\/doi.org\/10.1177\/87551225251396748","relation":{},"ISSN":["8755-1225","1549-4810"],"issn-type":[{"value":"8755-1225","type":"print"},{"value":"1549-4810","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]}}}