{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:51:10Z","timestamp":1777884670301,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmacy Technology"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    Itraconazole is recommended as the first-line oral treatment for pulmonary histoplasmosis. There is a paucity of data describing hypersensitivity reactions to itraconazole and lack of clarity on triazole antifungal cross-reactivity.\n                    <jats:bold>Case:<\/jats:bold>\n                    Approximately 9\u2009hours after an initial dose of itraconazole 200 mg for treatment of chronic cavitary pulmonary histoplasmosis, a 72-year immunocompetent patient developed anaphylactic symptoms that abated with intervention. To resume histoplasmosis treatment in the setting of limited treatment options following nephrotoxicity that occurred while receiving amphotericin B, a single posaconazole 100 mg tablet was given and well tolerated by the patient. Subsequently a treatment course of posaconazole 300 mg began with confirmation of therapeutic drug levels prior to hospital discharge. Imaging after 2 months of posaconazole showed improvement in cavitation size.\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Posaconazole was a safe and effective alternative to itraconazole for chronic cavitary pulmonary histoplasmosis in this case. Further evaluation of mechanisms and management of triazole hypersensitivity reactions are warranted.\n                  <\/jats:p>","DOI":"10.1177\/87551225251403429","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T10:30:15Z","timestamp":1765881015000},"page":"109-112","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Treatment of Histoplasmosis With Posaconazole in the Setting of a Severe Itraconazole Hypersensitivity Reaction: A Case Report"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7733-8690","authenticated-orcid":false,"given":"Kinsey M.","family":"Johannemann","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Huntsville Hospital, Huntsville, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8662-8557","authenticated-orcid":false,"given":"Megan Z.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Auburn University Harrison College of Pharmacy, Huntsville, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Allos","sequence":"additional","affiliation":[{"name":"Metro Infectious Disease Consultants, Huntsville, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeline","family":"Belk","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Huntsville Hospital, Huntsville, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6448-3879","authenticated-orcid":false,"given":"Spencer H.","family":"Durham","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, Auburn University Harrison College of Pharmacy, Huntsville, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Huntsville Hospital, Huntsville, AL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Arnold S Spec A Baddley JW et al. 2025 clinical practice guideline update by the infectious diseases Society of America on Histoplasmosis: treatment of asymptomatic histoplasma pulmonary nodules (Histoplasmomas) and Mild or moderate acute pulmonary histoplasmosis in adults children and pregnant people. 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