{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T12:45:38Z","timestamp":1777812338978,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T00:00:00Z","timestamp":1296777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Dent Res"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:p>Therapeutic vaccination with Streptococcus sobrinus recombinant enolase (rEnolase) protects rats from dental caries. Here, we investigated the effect that maternal rEnolase vaccination before pregnancy had on the offspring\u2019s immune response to S. sobrinus oral infection and dental caries progression. Female Wistar rats were immunized by intranasal and subcutaneous routes with rEnolase adsorbed onto aluminum hydroxide as adjuvant or similarly treated with the adjuvant alone (sham-immunized). Ten days after the last administration, the immunized females were paired with a male rat. The oral immune responses to S. sobrinus infection and dental caries in the offspring were evaluated. The results showed that pups born from rEnolase-immunized mothers had higher levels of rEnolase-specific salivary IgA and IgG antibodies (indicating a placental antibody transfer) and lower sulcal and proximal enamel caries scores than rats born from sham-immunized mothers. In conclusion, rEnolase maternal immunization before pregnancy provides offspring with protection against S. sobrinus-induced dental caries.<\/jats:p>","DOI":"10.1177\/0022034510391793","type":"journal-article","created":{"date-parts":[[2011,2,4]],"date-time":"2011-02-04T14:55:10Z","timestamp":1296831310000},"page":"325-330","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["rEnolase Maternal Immunization Confers Caries Protection on Offspring"],"prefix":"10.1177","volume":"90","author":[{"given":"M.","family":"Dinis","sequence":"first","affiliation":[{"name":"Laboratory of Immunology, ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Largo Prof. Abel Salazar 2, 4099-003 Porto, Portugal"},{"name":"IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto"}]},{"given":"G.","family":"Trigo","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Largo Prof. Abel Salazar 2, 4099-003 Porto, Portugal"},{"name":"IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto"}]},{"given":"N.","family":"Chaves","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Largo Prof. Abel Salazar 2, 4099-003 Porto, Portugal"},{"name":"Faculdade de Ci\u00eancias e Tecnologia da Universidade de Coimbra"}]},{"given":"A.J.M.M.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Hospitais da Universidade de Coimbra"}]},{"given":"A.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Largo Prof. Abel Salazar 2, 4099-003 Porto, Portugal"},{"name":"IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto"}]},{"given":"D.","family":"Tavares","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Largo Prof. Abel Salazar 2, 4099-003 Porto, Portugal"},{"name":"IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto"}]},{"given":"A.M.S.","family":"Cabrita","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade de Coimbra, Portugal"}]},{"given":"P.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar, Largo Prof. Abel Salazar 2, 4099-003 Porto, Portugal"},{"name":"IBMC-Instituto de Biologia Molecular e Celular, Universidade do 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