{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:58:16Z","timestamp":1790747896240,"version":"4.1.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Medical Science Research Project of Hebei","award":["20212246"],"award-info":[{"award-number":["20212246"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Frailty is prevalent in cardiovascular disease but lacks objective assessment tools in critical care. This study evaluated the association between the Frailty Index based on laboratory data (FI-LAB) at ICU admission and clinical outcomes in critically ill patients with coronary artery disease (CAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study used data from the MIMIC-IV and MIMIC-III Carevue databases. Patients were stratified by FI-LAB into mild (&lt;0.25), moderate (0.25\u20130.4), and severe (&gt;0.4) frailty. Multivariable logistic regression assessed in-hospital mortality, Cox models evaluated 28-day and 1-year mortality, and Fine-Gray competing risk models examined malignant arrhythmia. Dose-response relationships and subgroup effects were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After full adjustment, severe frailty was associated with elevated in-hospital mortality (OR = 4.41, 95% CI: 2.60\u20137.48,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), 28-day mortality (HR = 3.42, 95% CI: 2.17\u20135.40,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), and 1-year mortality (HR = 3.60, 95% CI: 2.56\u20135.06,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Moderate frailty similarly conferred increased risks for 28-day (HR = 1.70,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.026) and 1-year mortality (HR = 2.09,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The Fine-Gray model showed that severe frailty was associated with a higher subdistribution hazard of malignant arrhythmia (SHR = 2.68, 95% CI: 1.39\u20135.18,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003). A nonlinear relationship between FI-LAB and 1-year mortality was observed (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      for nonlinearity = 0.042). Results were consistent in the MIMIC-III cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher FI-LAB scores at ICU admission were associated with increased risks of in-hospital mortality, 28-day mortality, 1-year mortality, and malignant arrhythmia. FI-LAB may serve as a useful prognostic tool for risk stratification in critically ill patients with CAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504261477983","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:01:16Z","timestamp":1786446076000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between frailty and clinical outcomes in critically ill coronary artery disease patients: A retrospective cohort study"],"prefix":"10.1177","volume":"109","author":[{"given":"Mengxiao","family":"Wang","sequence":"first","affiliation":[{"name":"The Second Hospital of Hebei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjian","family":"Guan","sequence":"additional","affiliation":[{"name":"The Second Hospital of Hebei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianli","family":"Ma","sequence":"additional","affiliation":[{"name":"The Second Hospital of Hebei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaotong","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Hebei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"Hebei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9526-4575","authenticated-orcid":false,"given":"Bing","family":"Xiao","sequence":"additional","affiliation":[{"name":"The Second Hospital of Hebei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.15212\/CVIA.2023.0069"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.2467"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202102-178OC"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.03.007"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4940-8"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2011"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000741"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319654"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad885"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2016.03.007"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0171-9"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-022-01899-x"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2016.35"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.23.e215"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afac309"},{"key":"e_1_3_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31785-4"},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu057"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2011.06.005"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0511-506"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12010044"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afab138"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13197"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2253-14-59"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-04997-x"},{"key":"e_1_3_6_28_2","first-page":"e076246","article-title":"Management of atrial fibrillation in older adults","volume":"386","author":"Parks AL","year":"2024","unstructured":"Parks AL, Frankel DS, Kim DH, et al. Management of atrial fibrillation in older adults. BMJ (Clinical research ed) 2024; 386: e076246. https:\/\/doi.org\/10.1136\/bmj-2023-076246","journal-title":"BMJ (Clinical research ed)"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101652"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afac192"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13499"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau8680"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP274134"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa212"},{"key":"e_1_3_6_35_2","article-title":"Roles of Major Chemokines in the Pathophysiology of Atrial Fibrillation","volume":"9","author":"Rafaqat S","year":"2024","unstructured":"Rafaqat S, Bibi F, Murad MA, et al. Roles of Major Chemokines in the Pathophysiology of Atrial Fibrillation. CVIA 2024; 9: https:\/\/doi.org\/10.15212\/cvia.2024.0051","journal-title":"CVIA"}],"container-title":["Science Progress"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504261477983","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00368504261477983","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00368504261477983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:19:04Z","timestamp":1790745544000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00368504261477983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1177\/00368504261477983"],"URL":"https:\/\/doi.org\/10.1177\/00368504261477983","relation":{},"ISSN":["0036-8504","2047-7163"],"issn-type":[{"value":"0036-8504","type":"print"},{"value":"2047-7163","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"00368504261477983"}}