{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:59:12Z","timestamp":1790747952035,"version":"4.1.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1103602C"],"award-info":[{"award-number":["TCVGH-1103602C"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1103601D"],"award-info":[{"award-number":["TCVGH-1103601D"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1113602D"],"award-info":[{"award-number":["TCVGH-1113602D"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1123603C"],"award-info":[{"award-number":["TCVGH-1123603C"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Science Progress"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Autosomal dominant polycystic kidney disease (ADPKD) is a progressive hereditary kidney disorder with limited treatment options. Although semaglutide has demonstrated kidney-protective effects in other populations, its renal effects in ADPKD remain unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective propensity score\u2013matched cohort study using the TriNetX Research Network. Adults with ADPKD between 2000 and 2024 were identified. Patients receiving sodium-glucose cotransporter-2 inhibitors, tolvaptan, or other glucagon-like peptide-1 receptor agonists were excluded. Semaglutide users were matched 1:1 with non-users. Outcomes included creatinine-based estimated glomerular filtration rate (eGFR), stage 5 chronic kidney disease (CKD), end-stage kidney disease (ESKD), body mass index (BMI), acute kidney injury (AKI), urinary tract infection (UTI), volume depletion, and all-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 45,613 adults with ADPKD, 323 semaglutide users and 31,300 non-users met the eligibility criteria; 320 matched pairs were analyzed. At follow-up, semaglutide users had a higher mean creatinine-based eGFR than non-users (57.52 \u00b1 28.19 vs. 50.93 \u00b1 33.80 mL\/min\/1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      ; p = 0.013) and a lower risk of progression to stage 5 CKD (hazard ratio, 0.447; 95% confidence interval, 0.230\u20130.872). No significant differences were observed in ESKD, AKI, or UTI. Semaglutide use was also associated with lower incidences of volume depletion and all-cause mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Semaglutide use was associated with higher follow-up eGFR of creatinine-based eGFR and a lower risk of stage 5 CKD in patients with ADPKD. Because semaglutide-induced weight loss and reductions in muscle mass may lower serum creatinine independently of true glomerular filtration, the observed preservation of creatinine-based eGFR should be interpreted cautiously. Given the observational design, limited follow-up, and potential residual confounding, these findings should be considered hypothesis-generating and require confirmation in prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00368504261484176","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:23:37Z","timestamp":1787783017000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of semaglutide use with kidney outcomes in adults with ADPKD: A propensity score\u2013matched real-world study"],"prefix":"10.1177","volume":"109","author":[{"given":"To-Pang","family":"Chen","sequence":"first","affiliation":[{"name":"Show Chwan Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6119-0587","authenticated-orcid":false,"given":"Shang-Feng","family":"Tsai","sequence":"additional","affiliation":[{"name":"Taichung Veterans General Hospital"},{"name":"National Chung Hsing University"},{"name":"Taichung Veterans General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"issue":"5","key":"e_1_3_7_2_2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.kint.2022.06.008","article-title":"KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease. Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group","volume":"102","year":"2022","unstructured":"KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease. Kidney Disease: Improving Global Outcomes (KDIGO) Diabetes Work Group. Kidney Int 2022; 102(5S): S1\u2013S127. https:\/\/doi.org\/10.1016\/j.kint.2022.06.008","journal-title":"Kidney Int"},{"issue":"4","key":"e_1_3_7_3_2","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease","volume":"105","year":"2024","unstructured":"KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. Kidney Int 2024; 105(4S): S117\u2013S314. https:\/\/doi.org\/10.1016\/j.kint.2023.10.018","journal-title":"Kidney Int"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024816"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2204233"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2025845"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfae132"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2403347"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60601-1"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205511"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1710030"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202501605R"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu16183216"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-025-04217-w"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017070819"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32782-X"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04140510"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu17010145"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015020132"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"issue":"1","key":"e_1_3_7_21_2","first-page":"95","article-title":"Elevated Serum Levels of Galectin-3 and Kidney Injury Molecule-1 as Potential Biomarkers for Early Detection and Staging of Chronic Kidney Disease in Iraqi Population","volume":"14","author":"Ameer MN","year":"2025","unstructured":"Ameer MN, Choobineh H, Hashim Abdulsalam A, et al. 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